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    GENE:

    PRXL2B (Peroxiredoxin Like 2B)

    i
    Other names: PRXL2B, Peroxiredoxin Like 2B, Prostamide/Prostaglandin F Synthase, C1orf93, FAM213B, Thioredoxin-Type PGF Synthase, Prostamide/PG F Synthase, Prostamide/PGF Synthase, MGC26818, Family With Sequence Similarity 213, Member B, Family With Sequence Similarity 213 Member B, Chromosome 1 Open Reading Frame 93, Peroxiredoxin-Like 2B, Protein FAM213B
    Associations

    News

    Trials
    9ms
    TNFα activation of the PLEKHA5-FCRLA axis disturbs lipid metabolism, leading to the progression of cutaneous malignant melanoma. (PubMed, Lipids Health Dis)
    The predictive model of CMM related to lipid metabolism was constructed. TNFα activates the PLEKHA5-FCRLA axis to enhance neutral lipid storage and energy metabolism in CMM cells, promoting malignant behavior.
    Journal
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    TNFA (Tumor Necrosis Factor-Alpha) • FCRLA (Fc Receptor Like A) • PRXL2B (Peroxiredoxin Like 2B)
    over3years
    Effects of oocyte vitrification on gene expression in the liver and kidney tissues of adult offspring. (PubMed, J Assist Reprod Genet)
    In conclusion, we first report that oocyte vitrification did not significantly change the global gene expression in offspring organs; nonetheless, it can still influence the transcription of a few functional genes. The potential adverse effects caused by oocyte vitrification need attention and further study.
    Journal
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    NTRK2 (Neurotrophic tyrosine kinase, receptor, type 2) • TPM3 (Tropomyosin 3) • PRXL2B (Peroxiredoxin Like 2B)
    almost4years
    Metformin inhibits the tumor-promoting effect of low-dose resveratrol, and enhances the anti-tumor activity of high-dose resveratrol by increasing its reducibility in triple negative breast cancer. (PubMed, Free Radic Biol Med)
    These findings conclude the anti-TNBC mechanism of HRes should be attributed to its antioxidant activity and metformin enhances its reducibility. Metformin combined with resveratrol exerts a synergistic therapeutic effect on TNBC and effectively prevents tumor progression.
    Journal
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    JAK3 (Janus Kinase 3) • CAT (Catalase) • PRXL2B (Peroxiredoxin Like 2B) • SOD3 (Superoxide dismutase 3)
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    metformin