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    BIOMARKER:

    PRSS3 underexpression

    i
    Other names: PRSS3, Serine Protease 3, Mesotrypsin, TRY3, TRY4, Protease, Serine, 4 (Trypsin 4, Brain), Protease, Serine 3, Brain Trypsinogen, Mesotrypsinogen, Trypsin III, Trypsin IV, Trypsin-3, PRSS4, Protease, Serine, 3 (Mesotrypsin), Pancreatic Trypsinogen III, Serine Protease 4, Trypsinogen IV, Trypsinogen 4, Trypsinogen 5
    Entrez ID:
    5646
    almost2years
    CpG Site-Specific Methylation-Modulated Divergent Expression of PRSS3 Transcript Variants Facilitates Nongenetic Intratumor Heterogeneity in Human Hepatocellular Carcinoma. (PubMed, Front Oncol)
    Aberrant expression of divergent PRSS3-SVs disrupted by site-specific CpG methylation may integrate the effects of oncogenic PRSS3-V2 and tumor-suppressive PRSS3-V1, resulting in the molecular diversity and functional plasticity of PRSS3 in HCC. Dysregulated expression of PRSS3-V2 by site-specific CpG methylation may have potential diagnostic value for patients with early HCC.
    Journal
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    PRSS3 (Serine Protease 3)
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    PRSS3 underexpression