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    DRUG CLASS:

    Protease inhibitor

    Related drugs:
    4d
    Immune homeostasis regulatory therapy in elderly sepsis patients: A multicenter, randomized, double-blind Pilot study (ChiCTR2500114959)
    P2, N=60, Not yet recruiting, The First Affiliated Hospital, Sun Yat-sen University; The First affiliated hospital, sun yat-sen university
    New P2 trial
    1m
    NELCER: Radiosensitizing Effect of Nelfinavir in Locally Advanced Carcinoma of Cervix (clinicaltrials.gov)
    P3, N=348, Active, not recruiting, Tata Memorial Hospital | Trial completion date: Sep 2025 --> Jan 2026
    Trial completion date
    |
    cisplatin • Viracept (nelfinavir) • ondansetron intravenous
    1m
    GLS4 Induces the Interferon Signaling Pathway During Hepatitis B Virus (HBV) Infection. (PubMed, J Med Virol)
    Besides, combination treatment with GLS4 and ritonavir elevates the frequencies of both peripheral blood IFNγ + NK cells and liver-resident IFNγ + CD8+ T cells in the pAAV/HBV1.2 hydrodynamic injection (HDI) model. Furthermore, GLS4 partially restores innate and adaptive immunity in vivo. This signifies a potentially effective strategy for achieving a functional cure for HBV infection.
    Journal
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    CD8 (cluster of differentiation 8) • IFNG (Interferon, gamma)
    |
    ritonavir
    1m
    Evaluation of CYT-108, A Recombinant Protease Inhibitor, for Treatment of Mild To Moderate Primary Osteoarthritis Of The Knee (clinicaltrials.gov)
    P1, N=19, Completed, Cytonics Corporation | Not yet recruiting --> Completed | Trial completion date: Dec 2024 --> Oct 2025
    Trial completion • Trial completion date
    1m
    Autophagy Maintenance (AUTOMAIN) (clinicaltrials.gov)
    P2, N=38, Recruiting, Medical University of South Carolina | Not yet recruiting --> Recruiting | N=20 --> 38 | Trial completion date: Dec 2027 --> Jun 2029 | Trial primary completion date: Dec 2026 --> Jun 2028
    Enrollment open • Enrollment change • Trial completion date • Trial primary completion date
    |
    Avastin (bevacizumab) • hydroxychloroquine • Viracept (nelfinavir)
    2ms
    Treating Anemia in Myelofibrosis With Repurposed Drugs (Nelfinavir) That Restore Iron Delivery to the Bone Marrow (clinicaltrials.gov)
    P1/2, N=10, Recruiting, University of California, Irvine
    New P1/2 trial
    |
    Viracept (nelfinavir)
    3ms
    Absence of Internal Low Echoes Can Be an Important Diagnostic Clue for Intraductal Tubulopapillary Carcinomas of the Pancreas: A Case Report. (PubMed, Cureus)
    The patient received ulinastatin and antibiotic therapy for pancreatic head tumor-induced acute pancreatitis...Diagnostic physicians should note that ITPNs have distinct margins, enhanced posterior echoes, and no internal low echoes due to their pathological structures. In addition, it is also important for diagnostic physicians to note that ITPN patients less often develop icterus due to both the mass softness and the lack of mucin production.
    Journal
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    CCND1 (Cyclin D1) • MUC2 (Mucin 2) • MUC5AC (Mucin 5AC)
    3ms
    The impact of continuous renal replacement therapy on the pharmacokinetics of eravacycline in patients with sepsis caused by CRAB/CRE infection: a prospective observational study (ChiCTR2500110877)
    P=N/A, N=20, Not yet recruiting, Beijing Shijitan Hospital, Capital Medical University; Beijing Shijitan Hospital, Capital Medical University
    New trial
    3ms
    The application of Da Cheng Qi Decoction in improving gastrointestinal dysfunction in acute pancreatitis through ultrasound-mediated electroconductive targeted acupoint transdermal drug delivery (ChiCTR2500110180)
    P=N/A, N=80, Not yet recruiting, Kunshan Traditional Chinese Medicine Hospital; Kunshan Hospital of Traditional Chinese Medicine
    New trial
    3ms
    Ulinastatin improves sepsis associated organ damage in children: a prospective multicenter randomized controlled clinical trial (ChiCTR2500110759)
    P4, N=364, Recruiting, Children's Hospital of Soochow University; Children's Hospital of Soochow University
    New P4 trial
    3ms
    Nelfinavir, Cisplatin, and External Beam Radiation Therapy for the Treatment of Locally Advanced Vulvar Cancer That Cannot Be Removed by Surgery (clinicaltrials.gov)
    P1, N=25, Recruiting, M.D. Anderson Cancer Center | N=18 --> 25
    Enrollment change
    |
    cisplatin • Viracept (nelfinavir)
    3ms
    CHASE: Trial to Evaluate Safety and Efficacy of KPI-012 Ophthalmic Solution in Participants With PCED (clinicaltrials.gov)
    P2, N=103, Terminated, Combangio, Inc | Trial completion date: Jun 2026 --> Oct 2025 | Active, not recruiting --> Terminated; Lack of efficacy
    Trial completion date • Trial termination