P=N/A, N=68, Not yet recruiting, Fujian Cancer Hospital; Fujian Cancer Hospital

P=N/A, N=495, Not yet recruiting, Henan Cancer Hospital; Henan Cancer Hospital

P=N/A, N=40, Not yet recruiting, Peking University Shenzhen Hospital; Peking University Shenzhen Hospital

P=N/A, N=32, Not yet recruiting, Xiangya Hospital, Central South University; Xiangya Hospital, Central South University

P=N/A, N=48, Completed, The Second Affiliated Hospital of Wenzhou Medical University; The Second Affiliated Hospital of Wenzhou Medical University

P2, N=88, Not yet recruiting, Southern Medical University Southern Hospital; Southern Medical University Southern Hospital

Progesterone and adiponectin receptor 3 (PAQR3) is a Golgi-localized seven-transmembrane protein that anchors rapidly accelerated fibrosarcoma kinase (Raf) and suppresses rat sarcoma/rapidly accelerated fibrosarcoma/mitogen-activated protein kinase kinase/extracellular signal-regulated kinase (Ras/Raf/MEK/ERK) signaling, thereby influencing cellular proliferation, differentiation, and metastasis...These effects are modulated by upstream regulators, including microRNA-543 (miR-543), circular RNA 0043280/microRNA-203a-3p (circ_0043280/miR-203a-3p), microRNA-15b (miR-15b), human epidermal growth factor receptor 2 (HER2), 5-aza-2'-deoxycytidine (5-Aza-CdR), autophagy-related 7 (ATG7), and damage-specific DNA binding protein 2 (DDB2). In conclusion, PAQR3 functions as a tumor suppressor and holds potential as a prognostic biomarker. Targeting PAQR3-related pathways may provide new therapeutic opportunities.

This study provided translational insights, enhancing the current understanding of testicular pathogenesis and contributing to the diagnosis and treatment of cryptorchidism.

Increasing evidence indicates that sex steroid hormones estrogen, progesterone, and testosterone modulate immune responses critical for MTB control...However, circulating hormone data in TB patients are inconsistent, highlighting the need for longitudinal, hormone-aware studies. Overall, sex hormone mediated immune modulation influences TB susceptibility and pathogenesis, and future research should adopt sex and hormone-dose-aware designs to optimize host-directed therapies.

Triple negative breast cancer (TNBC) is a breast cancer with a poor prognosis, marked by the absence of estrogen (ER) and progesterone (PR) receptors as well as human epidermal growth factor receptor (HER2) expression. Several skin-related side effects have been documented, such as pruritus, maculopapular rashes, vitiligo, lichenoid skin reactions, psoriasis, and, in rare cases, severe and potentially life-threatening conditions. We report a rare case of pembrolizumab-associated lichen planus in a 43-year-old woman who received pembrolizumab for neoadjuvant treatment of TNBC.

P3, N=68, Not yet recruiting, Changchun GeneScience Pharmaceutical Co., Ltd.

P2, N=51, Active, not recruiting, Northwestern University | Trial primary completion date: Dec 2025 --> Aug 2025