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    BIOMARKER:

    PRKCH fusion

    i
    Other names: PRKCH, Protein Kinase C Eta, Protein Kinase C Eta Type, NPKC-Eta, PRKCL, PKC-L, PKCL, Protein Kinase C, Eta, RP11, PRPF31, Pre-MRNA Processing Factor 31, Serologically Defined Breast Cancer Antigen NY-BR-99, U4/U6 Small Nuclear Ribonucleoprotein Prp31, U4/U6 SnRNP 61 KDa Protein, Protein 61K, HPrp31, PRP31, PRP31 Pre-MRNA Processing Factor 31 Homolog (S. Cerevisiae), PRP31 Pre-MRNA Processing Factor 31 Homolog (Yeast), PRP31 Pre-MRNA Processing Factor 31 Homolog, Pre-MRNA-Processing Factor 31, N
    Entrez ID:
    5583
    Related biomarkers:
    Expression
    Fusion
    almost3years
    Novel CD63-PRKCB fusion in a case of pigmented epithelioid melanocytoma. (PubMed, Pediatr Dermatol)
    While germline variants in the protein kinase cAMP-dependent regulatory type 1 alpha (PRKAR1A) gene have been associated with EBN and CC, fusions in protein kinase C-alpha (PRKCA) have been shown as sporadic drivers of PEM. Herein, we report the diagnosis and workup of a case of pigmented epithelioid melanocytoma with a novel protein kinase C-beta (PRKCB) fusion.
    Clinical • Journal
    |
    PRKCH (Protein Kinase C Eta) • PRKCA (Protein Kinase C Alpha) • PRKCB (Protein Kinase C Beta)
    |
    PRKCH fusion
    over4years
    [VIRTUAL] Preclinical evaluation of PRKC fusions and GNA11/GNAQ mutations as genetic drivers of PKC activation in non-MUM indications to support a phase 1/2 basket trial of IDE196 (AACR-II 2020)
    Assessment of cell lines harboring GNAQ/GNA11 hotspot/non-hotspot mutations for IDE196 sensitivity is ongoing.(1) An-Angela N. Van, Timothy R. Baffi, Maya T. Kunkel, Corina E. Antal and Alexandra C. Newton, FASEB J. (2018); vol 32, suppl.no. 1, abstract 687.6.
    P1/2 data • Pan tumor
    |
    GNAQ (G Protein Subunit Alpha Q) • GNA11 (G Protein Subunit Alpha 11) • HIF1A (Hypoxia inducible factor 1, alpha subunit) • PRKCH (Protein Kinase C Eta) • VWA2 (Von Willebrand Factor A Domain Containing 2)
    |
    GNAQ mutation • GNA11 mutation • PRKCH fusion • PRKCH-SPTB fusion
    |
    darovasertib (IDE196)