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    GENE:

    PRKACB (Protein Kinase CAMP-Activated Catalytic Subunit Beta)

    i
    Other names: PRKACB, Protein Kinase CAMP-Activated Catalytic Subunit Beta, Protein Kinase, CAMP-Dependent, Beta Catalytic Subunit, CAMP-Dependent Protein Kinase Catalytic Subunit Beta, Protein Kinase, CAMP-Dependent, Catalytic, Beta, PKA C-Beta, PKACb, Protein Kinase A Catalytic Subunit Beta, CAFD2, PKACB
    Associations

    News

    Trials
    11d
    PRKACB Attenuates Chondrocyte Loss and Inflammation in Osteoarthritis. (PubMed, Immun Inflamm Dis)
    PRKACB can increase cell viability and reduce inflammation by activating the PKA/CREB signaling pathway, and PRKACB is a novel target for OA treatment.
    Journal
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    IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • CXCL8 (Chemokine (C-X-C motif) ligand 8) • CASP3 (Caspase 3) • IL1B (Interleukin 1, beta) • ACAN (Aggrecan) • PRKACB (Protein Kinase CAMP-Activated Catalytic Subunit Beta)
    26d
    A novel prognostic model for Hedgehog signaling pathway-related genes predicts the prognosis of hepatocellular carcinoma. (PubMed, Front Oncol)
    Moreover, some functional pathways were identified in the high-risk group in the low-risk group. We developed a novel five-gene prognostic model centered on Hedgehog signaling pathway-related genes, which holds potential as a valuable prognostic tool for HCC and may provide guidance for immunotherapy selection.
    Journal • IO biomarker
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    BMP2 (Bone Morphogenetic Protein 2) • PRKACB (Protein Kinase CAMP-Activated Catalytic Subunit Beta) • ZIC2 (Zic Family Member 2)
    2ms
    Porphyromonas gingivalis extracellular vesicles promotes tumor metastasis in esophageal squamous cell carcinoma by inducing PRKACB/JNK/ NFATC2 axis. (PubMed, J Nanobiotechnology)
    Our findings suggest that Pg is highly prevalent in ESCC, and it is associated with poor prognosis, stage, and lymph node metastasis. As a consequence of increasing PRKACB expression, Pg-EVs activate the JNK pathway, resulting in an increase in NFATC2 expression.
    Journal
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    PRKACB (Protein Kinase CAMP-Activated Catalytic Subunit Beta)
    4ms
    CircANKRD52 Augments the Growth and Invasion of Melanoma Cells by Sponging miR-141-3p and Upregulating PRKACB. (PubMed, J Cell Mol Med)
    Moreover, circANKRD52 could bind to miR-141-3p, leading to upregulation of PRKACB, and downregulation of miR-141-3p restored melanoma cell growth and invasion. Our findings demonstrate that circANKRD52 promotes the growth and angiogenesis of melanoma cells by sponging miR-141-3p and upregulating PRKACB.
    Journal
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    MIR141 (MicroRNA 141) • PRKACB (Protein Kinase CAMP-Activated Catalytic Subunit Beta)
    6ms
    Deciphering pancreatobiliary intraductal oncocytic papillary neoplasms: integrative analysis of histomorphologic patterns, immunophenotypic markers, and emerging molecular biomarkers. (PubMed, World J Surg Oncol)
    IOPN exhibits distinct genetic alterations and a unique immune microenvironment. These features not only elucidate the mechanism underlying the relatively favorable prognosis of IOPN and IOPN-derived pancreatic cancers but also offer novel insights into immune regulation strategies for pancreatic cancer.
    Review • Journal • PD(L)-1 Biomarker • IO biomarker
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    PD-L1 (Programmed death ligand 1) • KIT (KIT proto-oncogene, receptor tyrosine kinase) • CD8 (cluster of differentiation 8) • CD4 (CD4 Molecule) • ATP1B1 (ATPase Na+/K+ transporting subunit beta 1) • DNAJB1 (DnaJ Heat Shock Protein Family (Hsp40) Member B1) • PRKACA (Protein Kinase CAMP-Activated Catalytic Subunit Alpha) • PRKACB (Protein Kinase CAMP-Activated Catalytic Subunit Beta)
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    PD-L1 expression
    8ms
    FENDRR Affects COAD Biological Behavior by Inhibiting the DUSP4/CREB/PRKACB Pathway. (PubMed, Int J Genomics)
    We establish FENDRR as a tumor-suppressing gene that plays a significant role in suppressing the advancement and metastatic spread of COAD. These findings underscore its diagnostic and prognostic utility in COAD.
    Journal
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    DUSP4 (Dual Specificity Phosphatase 4) • PRKACB (Protein Kinase CAMP-Activated Catalytic Subunit Beta)
    10ms
    Identification and verification of international neuroblastoma staging system (INSS) stage-related genes as potential biomarkers for neuroblastoma prognostic models. (PubMed, Front Cell Dev Biol)
    The model containing CNR1, PRKACB, CDKN3, and PCLAF can serve as a new prognostic biomarker for predicting the prognosis of patients with neuroblastoma. Findings on immune cell infiltration and immune checkpoints provide novel insights for the immunotherapy of neuroblastoma.
    Journal • IO biomarker
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    CDK3 (Cyclin Dependent Kinase 3) • CNR1 (Cannabinoid Receptor 1) • PCLAF (PCNA Clamp Associated Factor) • PRKACB (Protein Kinase CAMP-Activated Catalytic Subunit Beta)
    10ms
    Alpha-estradiol and (R)-(-)-ibuprofen inhibit gastric cancer progression via GLI1 G-quadruplex. (PubMed, Front Pharmacol)
    In vivo, both compounds reduced tumor growth and metastasis, with (R)-(-)-ibuprofen synergizing with cisplatin to enhance efficacy. Targeting GLI1 G4 structures with alpha-estradiol and (R)-(-)-ibuprofen effectively inhibits gastric cancer progression by blocking GLI1/PRKACB signaling. This study highlights G4-targeted therapy as a novel and clinically translatable strategy for gastric cancer treatment.
    Journal
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    GLI1 (GLI Family Zinc Finger 1) • PRKACB (Protein Kinase CAMP-Activated Catalytic Subunit Beta)
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    cisplatin
    11ms
    Prognostic and Immunotherapeutic Value of Regulatory T Cell Marker Gene Signature in Melanoma. (PubMed, Iran J Allergy Asthma Immunol)
    TRGS was identified as an independent prognostic indicator for melanoma, offering novel insights into the role of Tregs in modulating the TME. This study highlights the potential clinical utility of TRGs in melanoma diagnostics and personalized immunotherapy, providing a robust foundation for future therapeutic strategies.
    Journal • Gene Signature • IO biomarker
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    ARID5A (AT-Rich Interaction Domain 5A) • PSME1 (Proteasome Activator Subunit 1) • PRKACB (Protein Kinase CAMP-Activated Catalytic Subunit Beta) • SEMA4D (Semaphorin 4D)
    1year
    Integrating bioinformatics and machine learning to identify AhR-related gene signatures for prognosis and tumor microenvironment modulation in melanoma. (PubMed, Front Immunol)
    This study presents a comprehensive analysis of AhR-related genes in melanoma, highlighting MAP2K1, PRKACB, KLF5, and PIK3R2 as key prognostic markers and potential therapeutic targets. The integration of bioinformatics and machine learning provides a robust framework for enhancing prognostic evaluation in melanoma patients and offers new avenues for the development of treatments, particularly for those resistant to current immunotherapies.
    Journal • Gene Signature • IO biomarker
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    MAP2K1 (Mitogen-activated protein kinase kinase 1) • CD8 (cluster of differentiation 8) • CD4 (CD4 Molecule) • PIK3R2 (Phosphoinositide-3-Kinase Regulatory Subunit 2 ) • PRKACB (Protein Kinase CAMP-Activated Catalytic Subunit Beta)
    over1year
    Prediction model of male reproductive function damage caused by CHOP chemotherapy regimen for non-Hodgkin's lymphoma. (PubMed, BMC Cancer)
    The CHOP regimen induces male reproductive toxicity, potentially mediated through alterations in hormone levels and increased expression of inflammatory cytokines and oxidative stress. Using E2 as the sole predictor in the model accurately predicts the extent of reproductive damage, offering a non-invasive method for detecting reproductive system damage.
    Journal
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    IL6 (Interleukin 6) • CSF1 (Colony stimulating factor 1) • CASP3 (Caspase 3) • TGFB1 (Transforming Growth Factor Beta 1) • PRKACB (Protein Kinase CAMP-Activated Catalytic Subunit Beta)
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    doxorubicin hydrochloride • cyclophosphamide • vincristine • prednisone
    over1year
    The molecular genetics of adrenal cushing. (PubMed, Hormones (Athens))
    Syndromic PBMAH may be due to germline pathogenic variants in MEN1, APC, or FH, causing type 1 multiple endocrine neoplasia, familial adenomatous polyposis, or hereditary leiomyomatosis-kidney cancer syndrome, respectively. PRKAR1A germline pathogenic variants are the main alteration causing PPNAD (isolated or part of Carney complex).
    Review • Journal • BRCA Biomarker
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    TP53 (Tumor protein P53) • BRCA2 (Breast cancer 2, early onset) • NF1 (Neurofibromin 1) • MLH1 (MutL homolog 1) • MSH6 (MutS homolog 6) • MSH2 (MutS Homolog 2) • PMS2 (PMS1 protein homolog 2) • IGF2 (Insulin-like growth factor 2) • GNAS (GNAS Complex Locus) • PRKACA (Protein Kinase CAMP-Activated Catalytic Subunit Alpha) • PRKAR1A (Protein Kinase CAMP-Dependent Type I Regulatory Subunit Alpha) • CDKN1C (Cyclin Dependent Kinase Inhibitor 1C) • PRKACB (Protein Kinase CAMP-Activated Catalytic Subunit Beta) • ZNRF3 (Zinc And Ring Finger 3)