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    1m
    ARCHED: Acalabrutinib in Combination With R-miniCHOP in Older Adults With Untreated Diffuse Large B-Cell Lymphoma (clinicaltrials.gov)
    P3, N=330, Recruiting, Universitt des Saarlandes | Trial primary completion date: Apr 2028 --> Feb 2029
    Trial primary completion date
    |
    ALK (Anaplastic lymphoma kinase) • BCL2 (B-cell CLL/lymphoma 2) • CD20 (Membrane Spanning 4-Domains A1) • BCL6 (B-cell CLL/lymphoma 6) • IRF4 (Interferon regulatory factor 4)
    |
    Rituxan (rituximab) • cyclophosphamide • Calquence (acalabrutinib) • vincristine • prednisolone
    2ms
    M9466 Alone or in Combination in Advanced Solid Tumors (DDriver 501) (clinicaltrials.gov)
    P1, N=60, Active, not recruiting, EMD Serono Research & Development Institute, Inc. | N=141 --> 60
    Enrollment change
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    abiraterone acetate • prednisone • tuvusertib (M1774) • M9466 • prednisolone
    2ms
    Sarcomatoid Transformation of Pulmonary Mucinous Adenocarcinoma as a Mechanism of Immunotherapy Resistance. (PubMed, Thorac Cancer)
    As surgical resection was not feasible, first-line treatment with ipilimumab plus nivolumab combined with chemotherapy was initiated, resulting in a partial response...Thirteen months later, the patient developed radiographic worsening of ILD, for which oral prednisolone was initiated...The patient received two cycles of nab-paclitaxel plus carboplatin without response and subsequently died. These findings emphasize that clinicians should recognize that IMA may undergo sarcomatous transformation.
    Journal • PD(L)-1 Biomarker • IO biomarker
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    BRAF (B-raf proto-oncogene) • NKX2-1 (NK2 Homeobox 1) • VIM (Vimentin)
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    BRAF mutation
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    Opdivo (nivolumab) • Yervoy (ipilimumab) • carboplatin • albumin-bound paclitaxel • prednisolone
    2ms
    MYCOHYPE: An RCT of Mycophenolate Mofetil (MMF) in Fibrotic Hypersensitivity Pneumonitis (clinicaltrials.gov)
    P4, N=144, Active, not recruiting, Post Graduate Institute of Medical Education and Research, Chandigarh | Recruiting --> Active, not recruiting | Trial completion date: Oct 2025 --> Oct 2026 | Trial primary completion date: Sep 2025 --> Sep 2026
    Enrollment closed • Trial completion date • Trial primary completion date
    |
    prednisolone
    2ms
    AZD2265 Compared With Standard of Care in PSMA-positive Metastatic Castration-resistant Prostate Cancer (VECTRA-01) (clinicaltrials.gov)
    P3, N=670, Recruiting, AstraZeneca
    New P3 trial
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    FOLH1 positive
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    enzalutamide • abiraterone acetate • Nubeqa (darolutamide) • cabazitaxel • apalutamide • Xofigo (radium Ra-223 dichloride) • AiRuiEn (rezvilutamide) • FPI-2265 • prednisolone
    3ms
    Unmasking peripheral T-cell lymphoma in dermatomyositis with anti-PM/Scl-100 and anti-Mi-2 positivity: a case-based review. (PubMed, Rheumatol Int)
    She was diagnosed with DM and treated with oral prednisolone...These cases suggest that repeat tissue evaluation, particularly of skin lesions, may be critical in atypical or treatment-refractory cases. Our case highlights that even a DM phenotype with autoantibodies generally considered less strongly associated with malignancy does not exclude occult lymphoma in elderly patients.
    Review • Journal
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    IL2 (Interleukin 2)
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    prednisolone
    3ms
    COLTHYR: Colchicine for Autoimmune and Subacute Thyroiditis (clinicaltrials.gov)
    P2/3, N=300, Not yet recruiting, Mansoura University
    New P2/3 trial
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    prednisolone
    4ms
    Clinicopathological Features, Treatment Response, and Outcome of Rosai-Dorfman Disease in Two Children. (PubMed, Clin Case Rep)
    He responded poorly to cytotoxic drugs, but achieved a durable complete remission with three cycles of oral prednisolone...However, he achieved complete remission with a combination of oral methotrexate and vincristine...There is no universal standard guideline for managing Rosai-Dorfman disease. However, patients with symptomatic disease, those experiencing emergency symptoms, and cases of relapse will require medical or surgical intervention to improve their outcomes.
    Journal
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    CD68 (CD68 Molecule)
    |
    methotrexate • vincristine • prednisolone
    4ms
    The Effect of Three Different Medications on Anesthetic Success and Postoperative Pain (clinicaltrials.gov)
    P=N/A, N=124, Completed, Cairo University | Recruiting --> Completed
    Trial completion
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    prednisolone
    4ms
    042011: LCH-IV International Collaborative Treatment Protocol for Children and Adolescents with Langerhans Cell Histiocytosis (2024-512676-36-00)
    P2/3, N=1124, Active, not recruiting, St. Anna Childrens Cancer Research Institute GmbH | Not yet recruiting --> Active, not recruiting
    Enrollment closed
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    cytarabine • methotrexate • cladribine • melphalan • fludarabine IV • mercaptopurine • vinblastine • prednisolone
    4ms
    GLITZ: Oral Itraconazole Versus Combination of Systemic Glucorticoids and Oral Itraconazole in CPA-ABPA Overlap Syndrome (clinicaltrials.gov)
    P=N/A, N=104, Recruiting, Post Graduate Institute of Medical Education and Research, Chandigarh | Trial completion date: Dec 2025 --> Feb 2027 | Trial primary completion date: Dec 2024 --> Jan 2027
    Trial completion date • Trial primary completion date
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    prednisone • itraconazole • prednisolone
    5ms
    A Study of Adeno-Associated Virus Serotype 8-Mediated Gene Transfer of Glucose-6-Phosphatase in Patients With Glycogen Storage Disease Type Ia (GSDIa) (clinicaltrials.gov)
    P3, N=49, Completed, Ultragenyx Pharmaceutical Inc | Active, not recruiting --> Completed
    Trial completion
    |
    prednisolone