^
    Contact us  to learn more about
    our Premium Content:  News alerts, weekly reports and conference planners
    GENE:

    PRDX3 (Peroxiredoxin 3)

    i
    Other names: PRDX3, Peroxiredoxin 3, AOP-1, Antioxidant Protein 1, SP-22, MER5, AOP1, Thioredoxin-Dependent Peroxide Reductase, Mitochondrial, Thioredoxin-Dependent Peroxiredoxin 3, Protein MER5 Homolog, Peroxiredoxin III, Prx-III, HBC189, Epididymis Secretory Sperm Binding Protein, Peroxiredoxin-3, PRO1748, SCAR32, PPPCD
    Associations

    News

    Trials
    18d
    Involvement of Keap1/Nrf2 and the antioxidant defence in cytoprotective effects induced by cannabis polyphenols in SH-SY5Y neuronal cells. (PubMed, Biomed Pharmacother)
    In silico docking studies identified Leu583 as a key residue in Nrf2-ligand interactions. These findings suggest that Cannabis sativa L. polyphenols are key bioactive compounds modulating redox homeostasis and inflammation, and offering neuroprotective benefits with potential relevance in diseases involving mitochondrial dysfunction and oxidative damage.
    Journal • IO biomarker
    |
    BCL2 (B-cell CLL/lymphoma 2) • KEAP1 (Kelch Like ECH Associated Protein 1) • IL6 (Interleukin 6) • CXCL8 (Chemokine (C-X-C motif) ligand 8) • PRDX1 (Peroxiredoxin 1) • BAX (BCL2-associated X protein) • PRDX3 (Peroxiredoxin 3)
    6ms
    PRDX3 promotes nasopharyngeal carcinoma tumor growth by regulating PINK1/Parkin pathway-dependent lipid peroxidation and mitochondrial dysfunction. (PubMed, Exp Cell Res)
    PRDX3 acts as an upstream activator of the PINK1/Parkin signaling cascade, regulating lipid peroxidation-mediated mitochondrial dysfunction, mitophagy, survival and apoptosis of NPC cell.
    Journal
    |
    PTEN (Phosphatase and tensin homolog) • PRDX3 (Peroxiredoxin 3)
    2years
    Peroxiredoxin 3 regulates breast cancer progression via ERK-mediated MMP-1 expression. (PubMed, Cancer Cell Int)
    These findings suggest that PRDX3 could mediate cancer spread via ERK-mediated activation of MMP-1. Targeted inhibition of ERK signaling may be able to inhibit tumor metastasis in triple-negative breast cancer.
    Journal
    |
    MMP1 (Matrix metallopeptidase 1) • PRDX3 (Peroxiredoxin 3)
    almost3years
    Evaluating peroxiredoxins 1-6 and their potential as prognostic biomarkers for uterine corpus endometrial carcinoma (AACR 2023)
    High PRDX2, PRDX3, and PRDX4 expression could serve as favorable UCEC prognostic biomarkers, while high PRDX6 expression may be a novel unfavorable prognostic biomarker.
    PRDX1 (Peroxiredoxin 1) • PRDX2 (Peroxiredoxin 2) • PRDX3 (Peroxiredoxin 3)