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    BIOMARKER:

    PRDX2 overexpression

    i
    Other names: PRDX2, Peroxiredoxin 2, Thioredoxin-Dependent Peroxide Reductase 1, Thioredoxin Peroxidase 1, Natural Killer Cell-Enhancing Factor B, Thiol-Specific Antioxidant 1, NKEF-B , TDPX1, Epididymis Secretory Sperm Binding Protein Li 2a, Thioredoxin-Dependent Peroxiredoxin 2, Thiol-Specific Antioxidant Protein, Natural Killer-Enhancing Factor B, PTX1, TPX1
    Entrez ID:
    7001
    2years
    PRDX2 regulates stemness contributing to cisplatin resistance and metastasis in bladder cancer. (PubMed, Environ Toxicol)
    This study provides a new insight into the regulation of chemotherapy resistance in bladder cancer by PRDX2. Targeting PRDX2 can serve as a potent therapeutic target for chemotherapy resistance.
    Journal
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    PRDX2 (Peroxiredoxin 2)
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    PRDX2 overexpression
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    cisplatin
    2years
    Triptolide induces apoptosis and cytoprotective autophagy by ROS accumulation via directly targeting peroxiredoxin 2 in gastric cancer cells. (PubMed, Cancer Lett)
    Collectively, these results indicate PRDX2 as a direct target of Triptolides for inducing apoptosis. Our results not only provide novel insight into the underlying mechanisms of Triptolide-induced cytotoxic effects, but also indicate PRDX2 as a promising potential therapeutic target for developing anti-gastric cancer agents.
    Journal
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    PRDX2 (Peroxiredoxin 2)
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    PRDX2 overexpression
    2years
    Implications and progression of peroxiredoxin 2 (PRDX2) in various human diseases. (PubMed, Pathol Res Pract)
    A proper PRDX2 balance is therefore crucial. The imbalance causes a number of illnesses, including cancers, inflammatory diseases, cardiovascular ailments, and neurological and neurodegenerative problems which are discussed in this review.
    Review • Journal
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    PRDX2 (Peroxiredoxin 2)
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    PRDX2 overexpression
    2years
    Silencing of peroxiredoxin 2 suppresses proliferation and Wnt/β-catenin pathway, and induces senescence in hepatocellular carcinoma. (PubMed, Oncol Res)
    PRDX2 also was found to activate the Wnt/β-catenin pathway by inducing β-catenin nuclear translocation. Consequently, we proved that silencing PRDX2 could inhibit proliferation and Wnt/β-catenin pathway while promoting senescence in HCC cells.
    Journal
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    PRDX2 (Peroxiredoxin 2)
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    PRDX2 overexpression
    2years
    Exosome-derived miR-23a-5p inhibits HCC proliferation and angiogenesis by regulating PRDX2 expression: MiR-23a-5p/PRDX2 axis in HCC progression. (PubMed, Heliyon)
    In conclusion, Exo miR-23a-5p inhibited HCC proliferation and angiogenesis by regulating PRDX2 expression. Our results revealed the role and specific molecular mechanism of exo miR-23a-5p in regulating HCC progression.
    Journal
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    MIR23A (MicroRNA 23a) • PRDX2 (Peroxiredoxin 2)
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    PRDX2 overexpression • miR-23a expression