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    GENE:

    PPP2R2D (Protein Phosphatase 2 Regulatory Subunit Bdelta)

    i
    Other names: PPP2R2D, Protein Phosphatase 2 Regulatory Subunit Bdelta, B55delta, MDS026, B55D, Serine/Threonine-Protein Phosphatase 2A 55 KDa Regulatory Subunit B Delta Isoform, PP2A Subunit B Isoform Delta, Protein Phosphatase 2, Regulatory Subunit B, Delta Isoform, Protein Phosphatase 2 Regulatory Subunit B, Delta, PP2A Subunit B Isoform PR55-Delta, PP2A Subunit B Isoform B55-Delta, PP2A Subunit B Isoform R2-Delta, KIAA1541
    Associations

    News

    Trials
    10ms
    LncRNA SNHG25 facilitates colorectal cancer progression by upregulating PPP2R2D expression through sponging miR-329-3p. (PubMed, Cytotechnology)
    SNHG25 plays a carcinogenic role in CRC via regulation of the miR-329-3p/PPP2R2D axis. The online version contains supplementary material available at 10.1007/s10616-025-00753-3.
    Journal
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    SNHG5 (Small Nucleolar RNA Host Gene 5) • PPP2R2D (Protein Phosphatase 2 Regulatory Subunit Bdelta)
    almost2years
    MicroRNA-5010-5p ameliorates high-glucose induced inflammation in renal tubular epithelial cells by modulating the expression of PPP2R2D. (PubMed, BMJ Open Diabetes Res Care)
    Our findings suggest that increased miR-5010-5p expression reduces high glucose-induced inflammatory responses in renal tubular epithelial cells via the regulation of the target gene, PPP2R2D, which modulates AMPK phosphorylation. Therefore, miR-5010-5p may be a promising therapeutic target for DKD.
    Journal
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    TNFA (Tumor Necrosis Factor-Alpha) • CCL2 (Chemokine (C-C motif) ligand 2) • PPP2R2A (Protein Phosphatase 2, Regulatory Subunit B, Alpha) • IL1B (Interleukin 1, beta) • PPP2R2D (Protein Phosphatase 2 Regulatory Subunit Bdelta)
    over3years
    PPP2R2D Suppresses Effector T Cell Exhaustion and Regulatory T Cell Expansion and Inhibits Tumor Growth in Melanoma. (PubMed, J Immunol)
    We had shown previously that the protein phosphatase 2A regulatory subunit PPP2R2D suppresses IL-2 production, and PPP2R2D deficiency in T cells potentiates the suppressive function of regulatory T (Treg) cells and alleviates imiquimod-induced lupus-like pathology...The data demonstrate that PPP2R2D is a negative regulator of immune checkpoint receptors, and its absence exacerbates effector T cell exhaustion and promotes Treg cell expansion. We conclude that PPP2R2D protects against melanoma growth, and PPP2R2D-promoting regimens can have therapeutic value in patients with melanoma.
    Journal • PD(L)-1 Biomarker • IO biomarker
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    CD8 (cluster of differentiation 8) • PD-1 (Programmed cell death 1) • LAG3 (Lymphocyte Activating 3) • CTLA4 (Cytotoxic T-Lymphocyte Associated Protein 4) • HAVCR2 (Hepatitis A Virus Cellular Receptor 2) • CD44 (CD44 Molecule) • IL2 (Interleukin 2) • PPP2R2D (Protein Phosphatase 2 Regulatory Subunit Bdelta)
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    CD44 expression
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    Zyclara (imiquimod)