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    BIOMARKER:

    PPM1B overexpression

    i
    Other names: PPM1B, Protein Phosphatase, Mg2+/Mn2+ Dependent 1B, PP2CB, PPC2BETAX, PP2CBETA, Protein Phosphatase 1B, e34PP2C-Beta, Protein Phosphatase 1B (Formerly 2C), Magnesium-Dependent, Beta Isoform, Protein Phosphatase, Mg2+/Mn2+ Dependent, 1B, Protein Phosphatase 2C, Beta Isoform, Protein Phosphatase 2C-Like Protein, Protein Phosphatase 2C Isoform Beta, PP2C-Beta-X
    Entrez ID:
    5495
    2years
    RBM10 regulates the tumorigenic potential of human cancer cells by modulating PPM1B and YBX1 activities. (PubMed, Exp Cell Res)
    Importantly, these enhanced tumorigenic phenotypes can be reversed by overexpression of PPM1B. Our findings provide the mechanistic bases for functional loss of RBM10 in promoting tumorigenicity, and are potentially useful in the development of combined therapeutic strategies for cancer patients with defective RBM10.
    Journal
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    RBM10 (RNA Binding Motif Protein 10) • YBX1 (Y-Box Binding Protein 1) • PPM1B (Protein Phosphatase, Mg2+/Mn2+ Dependent 1B)
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    PPM1B overexpression