^
    Contact us  to learn more about
    our Premium Content:  News alerts, weekly reports and conference planners
    BIOMARKER:

    POU5F1 overexpression + NANOG overexpression

    i
    Other names: POU5F1, OCT4, POU Class 5 Homeobox 1, POU Domain, Class 5, Transcription Factor 1, Octamer-Binding Transcription Factor 3, Octamer-Binding Protein 3, Octamer-Binding Protein 4, OTF-3, Oct-3, Oct-4, OTF3, OCT3, OCT4, POU-Type Homeodomain-Containing DNA-Binding Protein, POU Class 5 Homeobox 1 Transcript Variant OCT4B1, POU Class 5 Homeobox 1 Transcript Variant OCT4B2, POU Class 5 Homeobox 1 Transcript Variant OCT4B3, POU Class 5 Homeobox 1 Transcript Variant OCT4B4, POU Class 5 Homeobox 1 Transcript Variant OCT4B5, POU Class 5 Homeobox 1 Transcript Variant OCT4B6, POU Domain Class 5, Transcription Factor 1, POU Domain Transcription Factor OCT4, POU ClassV Homeobox 1 Variant 2, OTF4, NANOG, Nanog Homeobox, Homeobox Transcription Factor Nanog, Homeobox Protein NANOG, Homeobox Transcription Factor Nanog-Delta, FLJ12581, FLJ40451, HNanog
    Entrez ID:
    5460; 79923
    Related biomarkers:
    Expression
    Fusion
    over1year
    Modeling human brain rhabdoid tumor by inactivating tumor suppressor genes in induced pluripotent stem cells. (PubMed, Bioact Mater)
    Ribociclib, PTC-209, and the combination of clofilium tosylate and pazopanib decreased the viability of the ATRT-like cells. This disease modeling scheme may enable the establishment of individualized tumor models with patient-specific mutations and facilitate high-throughput drug testing.
    Journal
    |
    TP53 (Tumor protein P53) • NPM1 (Nucleophosmin 1) • CTNNB1 (Catenin (cadherin-associated protein), beta 1) • SMARCB1 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily B, Member 1) • SPP1 (Secreted Phosphoprotein 1) • POU5F1 (POU Class 5 Homeobox 1) • NANOG (Nanog Homeobox)
    |
    CTNNB1 expression • POU5F1 overexpression + NANOG overexpression • POU5F1 expression
    |
    pazopanib • Kisqali (ribociclib) • PTC-209