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DRUG:

PMB-CT01

i
Other names: PMB-CT01, BAFF-R CAR-T cells, PMBCT01, PMB CT01
Associations
Company:
PeproMene Bio
Drug class:
BAFF-R-targeted CAR-T immunotherapy
Associations
9ms
BAFFR Targeting CAR-T Cells for the Treatment of Relapsed or Refractory B-cell ALL (clinicaltrials.gov)
P1, N=24, Recruiting, PeproMene Bio, Inc. | Trial completion date: Nov 2026 --> Nov 2027 | Trial primary completion date: Nov 2025 --> Nov 2026
Trial completion date • Trial primary completion date • CAR T-Cell Therapy
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TNFRSF13C expression
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PMB-CT01
1year
Promising Safety and Anti-Lymphoma Efficacy of Autologous Pmb-CT01 (BAFFRCAR T Cell) Therapy in a First-in-Human Phase 1 Study (ASH 2023)
The lymphodepletion regimen consists of cyclophosphamide 500 mg/m2/day and fludarabine 30 mg/m2/day for 3 days...All CRS events resolved with 2 doses of tocilizumab given to patient #1 and 1 dose to patient #2... PMB-CT01(BAFFRCAR T cell) treatment at DL1 was safe and demonstrated potent anti-lymphoma activity with a 100% ORR (2 CR, 1 PR) in patients with poor prognosis. CRS and ICANS were all grade 1 and reversible. Enrollment is ongoing at DL2, and additional clinical and correlative analyses will be presented at the meeting.
Clinical • P1 data • CAR T-Cell Therapy
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CD20 (Membrane Spanning 4-Domains A1) • CD19 (CD19 Molecule)
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CD19 expression • TNFRSF13C expression
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cyclophosphamide • fludarabine IV • Actemra IV (tocilizumab) • PMB-CT01
1year
PMB-BAFFR-102: BAFFR-targeting CAR T Cells for Patients With Relapsed or Refractory B-NHL (clinicaltrials.gov)
P1; N=18 --> 36 | Trial completion date: Jun 2026 --> Jun 2028 | Trial primary completion date: Jul 2025 --> Jul 2027
CAR T-Cell Therapy • Trial completion date • Trial primary completion date • Enrollment change
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BCL2 (B-cell CLL/lymphoma 2) • BCL6 (B-cell CLL/lymphoma 6)
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BCL6 rearrangement • BCL2 rearrangement • CD20 negative • TNFRSF13C expression
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clonoSEQ
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PMB-CT01
almost2years
BAFFR Targeting CAR-T Cells for the Treatment of Relapsed or Refractory B-cell ALL (clinicaltrials.gov)
P1; Trial completion date: Apr 2025 --> Nov 2026 | Trial primary completion date: Apr 2024 --> Nov 2025
CAR T-Cell Therapy • Trial completion date • Trial primary completion date
|
TNFRSF13C expression
|
clonoSEQ
|
PMB-CT01
2years
CAR T-Cell Therapy • Trial completion date • Enrollment change
|
CD19 (CD19 Molecule)
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TNFRSF13C expression
|
clonoSEQ
|
PMB-CT01
2years
PMB-BAFFR-102: BAFFR-targeting CAR T Cells for Patients With Relapsed or Refractory MCL (clinicaltrials.gov)
P1; Trial completion date: Jun 2024 --> Jun 2026 | Trial primary completion date: Jun 2024 --> Jul 2025
CAR T-Cell Therapy • Trial completion date • Trial primary completion date
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TNFRSF13C expression
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clonoSEQ
|
PMB-CT01
over2years
CAR T-Cell Therapy • Enrollment open
|
TNFRSF13C expression
|
clonoSEQ
|
PMB-CT01
over2years
CAR T-Cell Therapy • New P1 trial
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TNFRSF13C expression
|
clonoSEQ
|
PMB-CT01
almost3years
CAR T-Cell Therapy • Enrollment change • Enrollment open • Clinical
|
CD19 (CD19 Molecule)
|
TNFRSF13C expression
|
clonoSEQ
|
PMB-CT01
3years
CAR T-Cell Therapy • Enrollment closed • Clinical
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CD19 (CD19 Molecule)
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TNFRSF13C expression
|
clonoSEQ
|
PMB-CT01
over3years
CAR T-Cell Therapy • Trial suspension • Clinical
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CD19 (CD19 Molecule)
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TNFRSF13C expression
|
clonoSEQ
|
PMB-CT01
over3years
Leukemia-Specific Immune Cells (BAFFR- CAR T Cells) for the Treatment of Relapsed or Refractory B-cell Acute Lymphoblastic Leukemia (clinicaltrials.gov)
P1; Trial completion date: Jan 2024 --> Apr 2024 | Initiation date: Jan 2021 --> Apr 2021 | Trial primary completion date: Jan 2024 --> Apr 2024
Trial completion date • Trial primary completion date • Trial initiation date • Clinical
|
CD19 (CD19 Molecule)
|
TNFRSF13C expression
|
clonoSEQ
|
PMB-CT01
almost4years
Clinical • New P1 trial • CAR T-Cell Therapy
|
CD19 (CD19 Molecule)
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PMB-CT01