PMAIP1 overexpression

Furthermore, we observed that PMAIP1 promotes virus replication by modulating mitochondrial function. In conclusion, the PMAIP1 gene facilitates virus replication by regulating mitochondrial function, thereby enriching our understanding of mitochondria-related genes and their involvement in ALV-J infection, offering valuable insights for avian leukosis disease resistance strategies.

Upregulation of Noxa expression suppressed the tumorigenesis of GC in vivo. The current investigation sheds light on the pivotal role of the hsa-miR-200b-3p/Noxa/ZNF519 axis in elucidating the pathogenesis of gastric cancer, offering a promising avenue for targeted therapeutic interventions in the management of this challenging malignancy.

Taken together these data underline the complexity of the mechanisms involved in venetoclax resistance and showed that the loss of BCL2 dependency can be due to NOXA downregulation and upregulation of MCL-1 and RUNX-1. Therefore, the use of agents that can prime BCL2-dependency through upregulation of NOXA and shifting BIM loading to BCL2 (RUNX1 inhibitors) could be explored in combination with venetoclax in MM patients who acquire MCL1 dependence following treatment.