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    BIOMARKER:

    PLK2 underexpression

    i
    Other names: PLK2, Polo Like Kinase 2, Serum-Inducible Kinase, SNK, Serine/Threonine-Protein Kinase PLK2, Serine/Threonine-Protein Kinase SNK, HPlk2, HSNK, Polo-Like Kinase 2 (Drosophila)
    Entrez ID:
    10769
    over4years
    Identification and assessment of PLK1/2/3/4 in lung adenocarcinoma and lung squamous cell carcinoma: Evidence from methylation profile. (PubMed, J Cell Mol Med)
    Global methylation survival analysis showed that prognostic value of PLK1/2/4 methylation remained the same significant trend between two lung cancer subtypes, whereas prognostic value of PLK3 methylation lacked consistency. Taken together, these results provided instructive insights into a comprehensive evaluation for advanced therapeutic strategy based on epigenetic evidences.
    Journal
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    TP53 (Tumor protein P53) • PLK1 (Polo Like Kinase 1) • PLK2 (Polo Like Kinase 2)
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    TP53 mutation • PLK1 overexpression • PLK2 underexpression