PLIN2 (Perilipin)

Standardized reporting is crucial for accurate diagnosis, management and prognosis. Improving compliance with core data reporting will enhance the quality of pathological information, which in turn enhances clinical decision making.

In addition, TRPS1 exhibited higher AUC values than GATA3 and adipophilin in differentiating primary and recurrent SCs, although the difference was not significant. Collectively, our findings indicate that the TRPS1/GATA3/adipophilin-based model demonstrated excellent discriminatory efficacy for eyelid malignancies (Kappa = 0.784, micro-average F1 = 0.882, AUC-ROC = 0.964 [95%CI:0.934-0.994]), achieving clinical-grade performance.

This study provides proof-of-concept supporting a nanoparticle-based agent as a LD homeostasis-targeted therapeutic to treat MASLD and related metabolic diseases.

Mechanistically, the hypoxic tumor microenvironment facilitates crosstalk between tumor cells and adipocytes, increasing triglyceride supply from adipocytes. This, in turn, promotes lipid droplet-mitochondria contact in HNSCC cells through PLIN2-CPT1A binding, counteracting cisplatin-induced ROS elevation and contributing to chemoresistance.

Our findings highlight the potential of exosomes in improving fat graft retention and overall tissue regeneration, suggesting that fat co-transplanted with exosomes from ASCs could serve as a superior alternative to SVF-enriched lipotransfer.

CD8+ T and NK cells exhibit functional polarization and altered cellular communication indicative of augmented anti-tumor immunity in ccRCC. The immune-cell-derived 10-gene signature provides a reliable prognostic tool and guides personalized therapy.

This study constructed an innovative CD8+ T cell-related risk model, advancing clinical diagnosis and offering valuable therapeutic strategies for patients with NSCLC.

These findings suggest that PLIN5 is a core regulatory protein that inhibits the activation of PSCs and alleviates pancreatic fibrosis, as well as a key protein in hindering pancreatic cancer progression.

In addition, eosinophil infiltration was observed in the glandular ducts of the tumor, and adipophilin was expressed in the tumor cytoplasm. This case highlights the rare coexistence of adipophilin expression and eosinophilia in IPMN, necessitating further investigation.

Various urinary biomarkers for RCC show promising diagnostic potential. The diagnostic ability of multi-biomarker panels often exceeded those of individual markers. However, individual markers and panels require external validation before clinical implementation.

Targeting HSP90A dampened LD mobilization and effectively prevented orthotopic HCC tumor growth induced by dietary MUFA. Collectively, our data demonstrated that dietary MUFA exhibits a distinctive tumor-promoting effect on HCC through HSP90A-mediated LD mobilization and suggested that targeting HSP90A-regulated autophagy may serve as a therapeutic strategy for the treatment of HCC.

In this review, we highlight recent advances in the understanding of PLIN2's role in the pathogenesis of liver disease through LD biogenesis, LD contact sites, LD dynamics, and lipophagy. Furthermore, we discuss the current opportunities for PLIN2-targeted therapy for liver disease.