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BIOMARKER:

PLIN2 expression

i
Entrez ID:
8d
CT Characterization of Lipid Metabolism in Clear Cell Renal Cell Carcinoma: Relationship Between Liver Hounsfield Unit Values and Adipose Differentiation-Related Protein Gene Expression. (PubMed, Int J Mol Sci)
While promising, these results require validation in larger, controlled studies due to sample size and variability limitations. This approach could enhance the radiogenomic assessment of ccRCC, supporting noninvasive insights into tumor metabolism and progression.
Journal
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PLIN2 (Perilipin)
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PLIN2 expression
28d
The Prognostic Impact of Adipophilin Expression on Long-Term Survival Following Liver Resection in Patients with Colorectal Liver Metastases. (PubMed, Cancers (Basel))
Moreover, multivariate Cox hazards analysis demonstrated that patients with ADP-positive CRLM had a worse prognosis after hepatectomy than those with ADP-negative CRLM, as reflected by both RFS (HR 2.46, 95% CI 1.39-4.36, p = 0.002) and OS (HR: 2.89, 95% CI 1.43-5.85, p = 0.003). ADP expression had a significant prognostic impact on the survival of patients with CRLM following liver resection and may aid in optimal treatment planning.
Journal
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PLIN2 (Perilipin)
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PLIN2 expression
2ms
Histologic Characterization of Tumor-Adjacent Mammary Adipose Tissue in Normal-Weight and Overweight/Obese Patients with Triple-Negative Breast Cancer. (PubMed, Cancers (Basel))
Moreover, expression of CD36 (BMI<25: 2.15 vs. BMI≥25: 2.60; p = 0.041) and ANGPTL4 (BMI<25: 6.00 vs. BMI≥25: 9.80; p = 0.026) was elevated in the TNBC cells of overweight/obese patients. Our data suggest BMI-related changes in the TME of overweight/obese TNBC patients, including hypertrophied adipocytes, reduced vascularization, more M2-like macrophages and CAF-like cells, and an increase in the expression of fatty acid metabolizing proteins in marginal tumor cells, all contributing to a more tumor-promoting, immunosuppressive environment.
Journal
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CD163 (CD163 Molecule) • CD34 (CD34 molecule) • CD36 (thrombospondin receptor) • VIM (Vimentin) • CD68 (CD68 Molecule) • CD31 (Platelet and endothelial cell adhesion molecule 1) • PECAM1 (Platelet And Endothelial Cell Adhesion Molecule 1) • PLIN2 (Perilipin) • ANGPTL4 (Angiopoietin Like 4) • FABP4 (Fatty Acid Binding Protein 4)
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PLIN2 expression
2ms
Exploring Morphological and Molecular Properties of Different Adipose Cell Models: Monolayer, Spheroids, Gellan Gum-Based Hydrogels, and Explants. (PubMed, Macromol Biosci)
Including, but not limited to, the strong differentiation in 2D-monolayers, the self-assembling within spheroids, the long-term stability of the stem cell-containing hydrogels, and the mature phenotype within adipocyte-containing hydrogels and the lobules. This study highlights the advantages of 3D models due to their more in vivo-like behavior and provides an overview of the different adipose cell models.
Journal
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PLIN2 (Perilipin)
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PLIN2 expression
3ms
Activation of NOD1 on tumor-associated macrophages augments CD8+ T cell-mediated antitumor immunity in hepatocellular carcinoma. (PubMed, Sci Adv)
This metabolic alteration promoted membrane localization of the costimulatory molecule OX40L in a lipid modification-dependent manner, thereby activating CD8+ T cells. These findings unveil a previously unrecognized role for NOD1 in fortifying antitumor T cell immunity in HCC, potentially advancing cancer immunotherapy.
Journal • PD(L)-1 Biomarker • IO biomarker
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CD8 (cluster of differentiation 8) • PLIN2 (Perilipin) • TNFSF4 (TNF Superfamily Member 4)
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PLIN2 expression
3ms
Exploring Tumor Heterogeneity: Radiogenomic Assessment of ADFP in Low WHO/ISUP Grade Clear Cell Renal Cell Carcinoma. (PubMed, Cancers (Basel))
This study reveals a significant association between metabolic lipid CT features and ADFP expression in ccRCC patients. Lower minimum tumoral HU values, suggestive of higher intracellular lipid accumulation, were observed in tumors with low WHO/ISUP grade and ADFP expression.
Journal
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PLIN2 (Perilipin)
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PLIN2 expression
8ms
Effects of Low-Intensity Pulsed Ultrasound on the Regulation of Free Fatty Acid Release in 3T3-L1 Cells. (PubMed, J Ultrasound Med)
LIPUS could promote the proliferation and differentiation of 3T3-L1 cells and inhibit TNF-α-induced lipolysis, indicating its potential as a therapy for mitigating lipotoxicity caused by decompensated adipocytes.
Journal
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TNFA (Tumor Necrosis Factor-Alpha) • PCNA (Proliferating cell nuclear antigen) • PPARG (Peroxisome Proliferator Activated Receptor Gamma) • PLIN2 (Perilipin)
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PLIN2 expression • PCNA expression
8ms
Periocular Sebaceous Carcinoma: A Case Audit from the National Specialist Ophthalmic Pathology Service in Liverpool from 2009 to 2022 to Assess the Diagnostic Utility of PRAME Expression. (PubMed, Ocul Oncol Pathol)
Although PRAME is expressed in normal sebaceous units, it appears less useful as diagnostic marker for PSC, especially in poorly differentiated tumors. In difficult cases, panels of IHC studies (adipophilin, Ber-EP4, and EMA) achieve a definitive diagnosis.
Journal
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AR (Androgen receptor) • PRAME (Preferentially Expressed Antigen In Melanoma) • PLIN2 (Perilipin) • PRF1 (Perforin 1)
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PRAME expression • PLIN2 expression
8ms
Cancer radioresistance is characterized by a differential lipid droplet content along the cell cycle. (PubMed, Cell Div)
In summary, although these results require further molecular studies about the mechanisms of radioresistance, the findings presented here are the first evidence that LD accumulation could participate in cancer cells' ability to better survive X-Ray radiation when cells are in the S phase. LDs can represent new players in the radioresistance processes associated with cancer metabolism. This could open new therapeutic avenues in which the use of LD-interfering drugs might enhance cancer sensitivity to radiation.
Journal
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PLIN2 (Perilipin)
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PLIN2 expression
9ms
TRIB3 promotes the progression of renal cell carcinoma by upregulating the lipid droplet-associated protein PLIN2. (PubMed, Cell Death Dis)
This simultaneously helps facilitate the accumulation of lipids while preserving ER homeostasis, thus driving accelerated RCC tumor progression. This TRIB3-PLIN2 axis thus represents a promising new target for efforts to treat RCC.
Journal
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PLIN2 (Perilipin) • TRIB3 (Tribbles Pseudokinase 3)
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PLIN2 expression • TRIB3 overexpression
11ms
Plin2 inhibits autophagy via activating AKT/mTOR pathway in non-small cell lung cancer. (PubMed, Exp Cell Res)
In vivo study showed that Plin2 stimulated subcutaneous tumorigenesis of NSCLC cells in nude mice. Collectively, this study clarified the carcinogenic role of Plin2 and its molecular mechanism in NSCLC progression, which may facilitate a targeted therapy in the future.
Journal
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PLIN2 (Perilipin)
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PLIN2 expression
11ms
Tumor-derived Prevotella intermedia aggravates gastric cancer by enhancing Perilipin 3 expression. (PubMed, Cancer Sci)
Our findings posit that P. intermedia from the tumor microenvironment plays a substantial role in the malignant progression of GC via the modulation of PLIN3 expression. Moreover, the relative abundance of P. intermedia might serve as a potential biomarker for the diagnosis and prognosis of GC.
Journal
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PLIN2 (Perilipin)
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PLIN2 expression
11ms
Analysis of gene expression changes during lipid droplet formation in HepG2 human liver cancer cells. (PubMed, Med Int (Lond))
Lipid droplet formation in the HepG2 cells induced by oleic acid led to the upregulation of PLIN2 in a concentration-dependent manner. On the whole, the findings of the present study indicate the involvement of genes in oleic acid-induced lipid droplet formation in HepG2 cells; PLIN2 in particular may play a crucial role in this process.
Journal
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PLIN2 (Perilipin)
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PLIN2 expression
1year
Anti‑adipogenic effect and underlying mechanism of lignan‑enriched nutmeg extract on 3T3‑L1 preadipocytes. (PubMed, Biomed Rep)
Furthermore, LNX treatment at the doses tested had no effect on tumor necrosis factor alpha-induced COX-2 expression in 3T3-L1 preadipocytes. Collectively, these results demonstrated that LNX has an anti-adipogenic effect on differentiating 3T3-L1 preadipocytes, which is mediated by the downregulation of STAT3 phosphorylation and FAS expression.
Journal
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TNFA (Tumor Necrosis Factor-Alpha) • CEBPA (CCAAT Enhancer Binding Protein Alpha) • PTGS2 (Prostaglandin-Endoperoxide Synthase 2) • FASN (Fatty acid synthase) • PPARG (Peroxisome Proliferator Activated Receptor Gamma) • PLIN2 (Perilipin)
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PTGS2 expression • PLIN2 expression
1year
Perilipin1 Expression as a Prognostic Factor in Patients with Squamous Cell Carcinoma of the Lung. (PubMed, Diagnostics (Basel))
High PLIN1 expression was significantly correlated with lower DFS in the Kaplan-Meier analysis and the multivariate Cox proportional hazards regression model. High PLIN1 expression was significantly correlated with worse prognosis in lung SCC.
Journal
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PLIN2 (Perilipin)
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PLIN2 expression
1year
Clinical
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PLIN2 (Perilipin)
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PLIN2 expression
1year
Malignant mesothelioma cells with characteristic intracytoplasmic vacuolization and lipids. (PubMed, Diagn Cytopathol)
In immunocytochemical analysis, tumor cells were positive for calretinin, podoplanin, epithelial membrane antigen, and methylthioadenosine phosphorylase; tumor cells were negative for BRCA1-associated protein 1, CD68, and desmin. The intracytoplasmic vacuoles were positive for adipophilin expression.
Journal • BRCA Biomarker
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MTAP (Methylthioadenosine Phosphorylase) • BAP1 (BRCA1 Associated Protein 1) • CD68 (CD68 Molecule) • PLIN2 (Perilipin)
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BRCA1 negative • PLIN2 expression
1year
The combination of the low immunohistochemical expression of peroxiredoxin 4 and perilipin 2 predicts longer survival in pancreatic ductal adenocarcinoma with peroxiredoxin 4 possibly playing a main role. (PubMed, Histol Histopathol)
Univariate and multivariate Cox proportional hazard analyses showed that the PRDX4 expression in PDAC was an independent prognostic factor for survival. Taken together, between PRDX4 and PLIN2, PRDX4 plays a main role in prognosis and has the potential to become a clinical prognostic indicator of PDAC.
Journal
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PLIN2 (Perilipin)
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PLIN2 expression
over1year
CANCER-ASSOCIATED ADIPOCYTES AND PROGNOSTIC VALUE OF PREOPERATIVE NEUTROPHIL-LYMPHOCYTE RATIO IN GASTRIC CANCER. (PubMed, Exp Oncol)
The results have clearly shown an association between preoperative NLR and the density of CAAs in the primary tumor of GC patients. The prognostic value of NLR is essentially modified by means of the individual density of intratumoral CAAs in GC patients.The elevated NLR could be of significant predictive potential for a negative prognosis for patients with tumors characterized by the high density of CAAs independently of BMI.
Retrospective data • Journal
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PLIN2 (Perilipin)
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PLIN2 expression
over1year
Journal
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PLIN2 expression
over1year
Integrative Analysis of the Predictive Value of Perilipin Family on Clinical Significance, Prognosis and Immunotherapy of Glioma. (PubMed, Biomedicines)
In addition, we determined that PLIN1 may affect glioma patients' therapeutic sensitivity to temozolomide. Our results demonstrated the biological significance and clinical values of PLINs in gliomas and provide a basis for future in-depth exploration of the specific mechanisms of each member of PLINs in gliomas.
Journal • IO biomarker
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PLIN2 (Perilipin)
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PLIN2 expression
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temozolomide
over1year
Novel prognostication biomarker adipophilin reveals a metabolic shift in uveal melanoma and new therapeutic opportunities. (PubMed, J Pathol)
Some of these molecules were able to impact tumour cell viability, and carvedilol, an adrenergic receptor antagonist, restored PLIN2 levels, mimicking the expression of normoxia/lipid storage signatures and reversing the expression of hypoxia/lipolysis signatures in co-cultures of uveal melanoma cells with human macrophages...Some of these molecules were able to impact tumour cells viability, and carvedilol, an adrenergic receptor antagonist, restored PLIN2 levels, mimicking the expression of normoxia/lipid storage signatures and reversing the expression of hypoxia/lipolysis signatures in co-cultures of uveal melanoma cells with human macrophages. These findings open a new research line for understanding the lipid metabolic regulation of immune responses, with implications for therapeutic innovation in uveal melanoma.
Journal
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BAP1 (BRCA1 Associated Protein 1) • PLIN2 (Perilipin)
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BAP1 negative • PLIN2 expression
over1year
Prognostic and clinicopathologic significance of PLIN2 in cancers: A systematic review with meta-analysis. (PubMed, Int J Biol Markers)
In summary, overexpression of PLIN2 is significantly associated with a poor prognosis in various human cancers, especially in respiratory and digestive malignancies. Thus, PLIN2 expression may be a potential prognostic biomarker in cancer patients.
Retrospective data • Review • Journal
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PLIN2 (Perilipin)
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PLIN2 expression
almost2years
Lipid droplets' functional protein caveolin-2 is associated with lipid metabolism-related molecule FABP5 and EMT marker E-cadherin in oral epithelial dysplasia. (PubMed, J Clin Pathol)
In the oral epithelial carcinogenesis process, LDs begin to accumulate early in the precancerous stage. LDs may be the regulator of FABP5-associated lipid metabolism and may closely related to the process of EMT; caveolin-2 could be the main functional protein.
Journal
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CDH1 (Cadherin 1) • PLIN2 (Perilipin) • FABP5 (Fatty Acid Binding Protein 5)
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CDH1 expression • PLIN2 expression
almost2years
PNPLA3(I148M) Inhibits Lipolysis by Perilipin-5-Dependent Competition with ATGL. (PubMed, Cells)
Furthermore, ballooned hepatocytes, the hallmark of steatohepatitis, were positive for PNPLA3 and perilipins 2 and 5, but showed decreased perilipin 1 expression with respect to neighboured hepatocytes. In summary, PNPLA3- and ATGL-driven lipolysis is significantly regulated by perilipin 1 and 5 in steatohepatitis.
Journal
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PLIN2 (Perilipin) • PNPLA3 (Patatin Like Phospholipase Domain Containing 3)
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PLIN2 expression
2years
Lipid droplet accumulation and adipophilin expression in follicular thyroid carcinoma. (PubMed, Biochem Biophys Res Commun)
In vitro treatment with phosphatidylinositol-3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) signaling inhibitors (LY294002, MK2206, and rapamycin) in FTC-133 cells downregulated the PI3K/Akt/mTOR/sterol regulatory element-binding protein 1 (SREBP1) signaling pathway, resulting in a significant reduction in LD accumulation. Immunohistochemical analysis of surgically resected human thyroid tissues revealed significantly increased expression of adipophilin in FTC compared with FTA and adjacent non-tumorous thyroid epithelia. Taken together, LDs and adipophilin were abundant in cultured FTC; the evaluation of adipophilin expression can help distinguish FTC from FTA in surgical specimens.
Journal
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PLIN2 (Perilipin)
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PLIN2 expression
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MK-2206 • LY294002
2years
Cannabidiolic acid activates the expression of the PPARβ/δ target genes in MDA-MB-231 cells. (PubMed, Arch Biochem Biophys)
Interestingly, ligand activation of PPARβ/δ with GW501516 caused an increase in expression of both ANGPTL4 and ADRP, but the magnitude of this effect was markedly increased when co-treated with CBDA. Specificity of these effects were confirmed by showing that CBDA-induced expression of ANGPTL4 and ADRP is mitigated in the presence of either a PPARβ/δ antagonist or an inverse agonist. Results from these studies suggest that CBDA can synergize with PPARβ/δ and might interact with endogenous agonists that modulate PPARβ/δ function.
Journal
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PPARG (Peroxisome Proliferator Activated Receptor Gamma) • ANGPTL4 (Angiopoietin Like 4) • PPARA (Peroxisome Proliferator Activated Receptor Alpha)
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PLIN2 expression
2years
Trip13 Depletion in Liver Cancer Induces a Lipogenic Response Contributing to Plin2-Dependent Mitotic Cell Death. (PubMed, Adv Sci (Weinh))
Plin2 expression in different tumor cells confers susceptibility to cell death induced by Trip13 depletion as well as treatment with paclitaxel, a spindle-interfering drug commonly used against different cancers. Thus, assessment of Plin2 levels enables the stratification of tumor responsiveness to mitosis-targeting drugs, including clinically approved paclitaxel and Trip13 inhibitors currently under development.
Journal
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IR (Insulin receptor) • PLIN2 (Perilipin) • RIPK1 (Receptor Interacting Serine/Threonine Kinase 1) • TRIP13 (Thyroid Hormone Receptor Interactor 13)
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PLIN2 expression
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paclitaxel
over2years
PLIN2 promotes HCC cells proliferation by inhibiting the degradation of HIF1α. (PubMed, Exp Cell Res)
Furthermore, we found that PLIN2 stabilized and retarded the degradation of the HIF1α through autophagy-lysosomal pathway by inhibiting AMPK/ULK1. Collectively, we clarified the carcinogenic role of PLIN2 in HCC and suggested a prognostic biomarker for diagnosis and clinical therapy in the future.
Journal
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HIF1A (Hypoxia inducible factor 1, alpha subunit) • PLIN2 (Perilipin) • AMPK (Protein Kinase AMP-Activated Catalytic Subunit Alpha 1)
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HIF1A expression • PLIN2 expression
over2years
Lipid droplets and perilipins in canine osteosarcoma. Investigations on tumor tissue, 2D and 3D cell culture models. (PubMed, Vet Res Commun)
Moreover, the biggest lipid droplets were found in the central zone of the spheroids at all sampling time-points, reaching their maximum size at 21 days. Thus, the 3D spheroids can be considered as a relevant in vitro model for further studies focusing on lipid droplets biology and function in osteosarcoma.
Preclinical • Journal
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PLIN2 (Perilipin)
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PLIN2 expression
over2years
LAMC1-mediated preadipocytes differentiation promoted peritoneum pre-metastatic niche formation and gastric cancer metastasis. (PubMed, Int J Biol Sci)
Furthermore, high LAMC1 expression in serum predicted a higher risk of peritoneal metastasis. In conclusion, our results illustrated that palmitic acid/p-STAT3/miR-193a-3p/LAMC1 pathway promotes preadipocyte differentiation, pre-metastatic niche formation and gastric cancer cell colonization to peritoneum.
Journal
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LAMC1 (Laminin Subunit Gamma 1)
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PLIN2 expression
over2years
Lactate rewires lipid metabolism and sustains a metabolic-epigenetic axis in prostate cancer. (PubMed, Cancer Res)
Clinically, PLIN2 expression was elevated in tumors with a higher Gleason grade and in castration resistant prostate cancer compared to primary PCa. Overall, these findings show that lactate has both a metabolic and an epigenetic role in promoting PCa progression.
Journal
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PLIN2 (Perilipin)
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PLIN2 expression
over2years
Lipid Droplet-Related PLIN2 in CD68 Tumor-Associated Macrophage of Oral Squamous Cell Carcinoma: Implications for Cancer Prognosis and Immunotherapy. (PubMed, Front Oncol)
Furthermore, a high PLIN2 presentation in the microenvironment induced immune suppression which was featured as less infiltration of CD8 T cells and more CD68 TAMs and Foxp3 Tregs, accompanied by more immune checkpoint molecules such as CSF1R, LGALS9, IL-10, CTLA-4, and TIGIT. CD68 TAM-derived PLIN2 might participate in regulating immune balance of OSCC patients, which provides new insight into immune checkpoint therapy.
Journal • IO biomarker
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CD8 (cluster of differentiation 8) • TIGIT (T Cell Immunoreceptor With Ig And ITIM Domains 2) • NCAM1 (Neural cell adhesion molecule 1) • IL10 (Interleukin 10) • CD68 (CD68 Molecule) • CSF1R (Colony stimulating factor 1 receptor) • FOXP3 (Forkhead Box P3) • PLIN2 (Perilipin) • LGALS9 (Galectin 9)
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PLIN2 expression
almost3years
Prognostic significance of adipophilin expression in biopsy specimens of patients with triple-negative breast cancer. (PubMed, Oncol Lett)
Furthermore, the concordance rate of ADP expression between biopsy and operative specimens was 73.1%, with a Cohen's kappa coefficient of 0.385 (P=0.003). These findings suggested that ADP expression in biopsy specimens might be a useful prognostic marker for patients with TNBC and could potentially provide important information regarding treatment strategies for these patients.
Journal
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PLIN2 (Perilipin)
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PLIN2 expression
almost3years
Association between fatty acid synthase and adipophilin expression in triple-negative breast cancer. (PubMed, Mol Clin Oncol)
The results of the present study revealed that FASN-high was associated with a lack of ADP expression and a lower Ki-67 labelling index. These results indicated that de novo fatty acid synthesis by FASN is not the main pathway of lipogenesis and the source of energy in cancer cells of ADP-positive highly proliferative TNBC.
Journal
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FASN (Fatty acid synthase) • PLIN2 (Perilipin)
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PLIN2 expression
almost3years
Dihydroartemisinin reduced lipid droplet deposition by YAP1 to promote the anti-PD-1 effect in hepatocellular carcinoma. (PubMed, Phytomedicine)
Anti-PD-1 promoted LD deposition, while YAP1 knockdown/out reduced LD deposition in HCC. DHA reduced LD deposition by inhibiting YAP1, enhancing the effect of anti-PD-1 therapy.
Journal • PD(L)-1 Biomarker • IO biomarker
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YAP1 (Yes associated protein 1) • PLIN2 (Perilipin)
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PLIN2 expression
3years
Clinicopathological and Molecular Characteristics of Macroscopically Yellowish-Colored Chromophobe Renal Cell Carcinoma Compared to Non-Yellowish-Colored Chromophobe Renal Cell Carcinoma. (PubMed, Clin Pathol)
Furthermore, we revealed that macroscopic color changes might be correlated with various clinicopathological features and immunohistochemical and molecular changes from different perspectives. We believe further characterization of RCC, including tumor heterogeneity, is needed to improve the management of patients with RCC.
Clinical • Journal
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PDGFB (Platelet Derived Growth Factor Subunit B) • PLIN2 (Perilipin) • E2F1 (E2F transcription factor 1)
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PLIN2 expression
3years
FV-429 enhances the efficacy of paclitaxel in NSCLC by reprogramming HIF-1α-modulated FattyAcid metabolism. (PubMed, Chem Biol Interact)
FV-429 activated and modulated fatty acid metabolism in NSCLC cells, significantly reduced levels of fatty acids within cells and increased the oxidation of these fatty acids. The results of our study demonstrated that FV-429 could reshape fatty acid metabolism in hypoxia-induced paclitaxel-resistant NSCLC and enhance the sensitivity of NSCLC cells to paclitaxel through G2/M phase arrest deterioration, by inactivating the Wnt pathway, and suggested the possibility of using FV-429 as a promising candidate therapeutic agent for advanced NSCLC.
Clinical • Journal
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HIF1A (Hypoxia inducible factor 1, alpha subunit) • FASN (Fatty acid synthase) • PLIN2 (Perilipin)
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HIF1A expression • PLIN2 expression
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paclitaxel
3years
Lipid Droplet Accumulation Independently Predicts Poor Clinical Prognosis in High-Grade Serous Ovarian Carcinoma. (PubMed, Cancers (Basel))
The acyl-CoA: cholesterol acyltransferase 1 inhibitor K604 and the hydroxymethylglutaryl-CoA reductase inhibitor pitavastatin blocked LD accumulation in OVCAR-3 cells and reduced phosphorylation of the survival-related kinases Akt and ERK1/2, both of which have been implicated in malignancy. Our cell-based assays thus suggested that enhanced aerobic glycolysis resulted in LD accumulation and activation of survival-related kinases. Overall, our results support the idea that cancers with lipogenic phenotypes are associated with poor clinical prognosis, and we suggest that adipophilin may serve as an independent indicator of a poor prognosis in HGSOC.
Clinical • Journal
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PLIN2 (Perilipin)
|
PLIN2 expression
|
pitavastatin
over3years
Perilipin 2 Impacts Acute Kidney Injury via Regulation of PPARα. (PubMed, J Immunol Res)
Overall, the present study demonstrated that Plin2 is involved in AKI; knockdown of this marker might limit apoptosis via the activation of PPARα. Consequently, the downregulation of Plin2 could be a novel therapeutic strategy for AKI.
Journal
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PLIN2 (Perilipin) • PPARA (Peroxisome Proliferator Activated Receptor Alpha)
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PLIN2 expression