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    BIOMARKER:

    PLAC8 overexpression

    i
    Other names: PLAC8, Placenta Associated 8, Placenta-Specific Gene 8 Protein, Placenta Specific 8, Onzin, C15, Down-Regulated In Gastrointestinal Cancer Protein, Protein C15, PNAS-144, DGIC
    Entrez ID:
    51316
    almost2years
    PLAC8 contributes to the malignant behaviors of cervical cancer cells by activating the SOX4-mediated AKT pathway. (PubMed, Histochem Cell Biol)
    Furthermore, PLAC8 overexpression upregulated the expression of sex-determining region Y-related high-mobility group box transcription factor 4 (SOX4), which is reported to mediate the activation of the AKT pathway, and SOX4 deficiency reversed the cellular functions caused by PLAC8 overexpression. Overall, the present study indicates that PLAC8 may facilitate CC development by activating the SOX4-mediated AKT pathway, suggesting that PLAC8 may serve as a potential biomarker for CC treatment.
    Journal
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    MMP2 (Matrix metallopeptidase 2) • VIM (Vimentin) • MMP9 (Matrix metallopeptidase 9) • PLAC8 (Placenta Associated 8) • ZEB1 (Zinc Finger E-box Binding Homeobox 1) • SOX4 (SRY-Box Transcription Factor 4)
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    VIM expression • PLAC8 overexpression
    over2years
    PLAC8 Overexpression Promotes Lung Cancer Cell Growth via Wnt/β-Catenin Signaling. (PubMed, J Immunol Res)
    The results of the dual luciferase reporter gene system suggest that PLAC8 can significantly activate the Wnt/β-Catenin signaling pathway in cells and can conduct signaling through it. A potential treatment targeting the prognosis of lung cancer patients may be PLAC8 overexpression, which promotes the lung cancer cell proliferation through controlling the Wnt/β-Catenin signaling pathway.
    Journal
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    PLAC8 (Placenta Associated 8)
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    PLAC8 overexpression