PIM2 overexpression

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Entrez ID:

almost3years

PIM2 KINASE REGULATES TIGIT EXPRESSION AND ENERGY METABOLISM IN NK CELLS OF PATIENTS WITH MULTIPLE MYELOMA (EHA 2023)

PIM2 kinase regulates NK cell anti-myeloma activity by modulating TIGIT expression and energy metabolism.Figure A.PIM2 was over expressed on NK cells from MM patients, the PIM2 kinase inhibitor improved NK cells function and decreased the expression of TIGIT. B.PIM2 kinase increased TIGIT expression on NK cell surface by up- regulated ETS-1. C.

almost 3 years ago

Clinical • IO biomarker

IFNG (Interferon, gamma) • TIGIT (T Cell Immunoreceptor With Ig And ITIM Domains 2) • LAMP1 (Lysosomal Associated Membrane Protein 1) • PVR (PVR Cell Adhesion Molecule) • ETS1 (ETS Proto-Oncogene 1)

IFNG expression • PIM2 overexpression

Q-Force (quercetin)

almost4years

Proviral Integration of Moloney Virus-2 (PIM-2) Expression Level as a Prognostic Marker in Patients with Acute Myeloid Leukemia. (PubMed, Int J Gen Med)

It was found that PIM-2 at cutoff ≤1.6 had an AUC (0.903) with a sensitivity (90.48%) and specificity (86.21%), P <0.001. Overexpression of the PIM-2 gene is associated with induction failure and low CR.

almost 4 years ago

Journal

GAPDH (Glyceraldehyde-3-Phosphate Dehydrogenase) • PIM2 (Pim-2 Proto-Oncogene, Serine/Threonine Kinase)

PIM2 overexpression

over4years

Myeloma-Bone Interaction: A Vicious Cycle via TAK1-PIM2 Signaling. (PubMed, Cancers (Basel))

The serine/threonine kinases PIM2 and TAK1, an upstream mediator of PIM2, are overexpressed in bone marrow stromal cells and osteoclasts as well in MM cells in bone lesions. Upregulation of the TAK1-PIM2 pathway plays a critical role in tumor expansion and bone destruction, posing the TAK1-PIM2 pathway as a pivotal therapeutic target in MM.

over 4 years ago

Review • Journal

DKK1 (dickkopf WNT signaling pathway inhibitor 1) • TGFB1 (Transforming Growth Factor Beta 1)

PIM2 overexpression