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    GENE:

    PIK3R3 (Phosphoinositide-3-Kinase Regulatory Subunit 3)

    i
    Other names: PIK3R3, Phosphoinositide-3-Kinase Regulatory Subunit 3, P55, Phosphatidylinositol 3-Kinase 55 KDa Regulatory Subunit Gamma, Phosphoinositide-3-Kinase, Regulatory Subunit 3 (Gamma), Phosphatidylinositol 3-Kinase Regulatory Subunit Gamma, PtdIns-3-Kinase Regulatory Subunit P55-Gamma, PI3-Kinase Regulatory Subunit Gamma, PI3K Regulatory Subunit Gamma, PI3-Kinase Subunit P55-Gamma, P55PIK, Phosphatidylinositol 3-Kinase, Regulatory Subunit, Polypeptide 3 (P55, Gamma), Phosphoinositide-3-Kinase Regulatory Subunit Gamma, PtdIns-3-Kinase Regulatory Subunit Gamma, P55-GAMMA
    Associations

    News

    Trials
    16d
    Identification of PI3K gene family in large yellow croaker (Larimichthys crocea): Expression patterns under Pseudomonas plecoglossicida infection and hypoxia stress, and functional verification of pik3r3b. (PubMed, Fish Shellfish Immunol)
    Based on these observations, we further conducted functional verification on Lcpik3r3b and discovered that its recombinant protein could significantly inhibit the proliferation of E. coli. These results would provide valuable insights into the roles of the PI3K family in mediating immune and stress responses in large yellow croaker, and laid a foundation for future investigations into their molecular mechanisms as well as potential applications in aquaculture disease management.
    Journal
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    PTEN (Phosphatase and tensin homolog) • PDPK1 (3-Phosphoinositide dependent protein kinase 1) • PI3K (Phosphoinositide 3-kinases) • PIK3R3 (Phosphoinositide-3-Kinase Regulatory Subunit 3)
    2ms
    Decoding molecular signatures and identifying therapeutic targets in triple-negative breast cancer subtypes using omics and network analysis. (PubMed, Sci Rep)
    Our findings indicate that, based on alteration patterns, survivability, differential gene and protein level expressions, the genes ERBB3, ERBB4, HLA-B, AKT1, GNAS, FGFR4, PIK3R3 and AXIN2 emerge as primary risk factors in TNBC. These genes, associated with specific subtypes, are potential markers and should be the focus of further studies, paving the way for personalized anticancer treatment strategies for TNBC patients.
    Journal
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    ERBB3 (V-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3) • AKT1 (V-akt murine thymoma viral oncogene homolog 1) • FGFR4 (Fibroblast growth factor receptor 4) • ERBB4 (erb-b2 receptor tyrosine kinase 4) • GNAS (GNAS Complex Locus) • HLA-B (Major Histocompatibility Complex, Class I, B) • PIK3R3 (Phosphoinositide-3-Kinase Regulatory Subunit 3)
    3ms
    Developing a Radiotherapy and Immune-Related Genes-Based Prognostic Model to Predict Prognosis and Immune Microenvironment in Thyroid Cancer. (PubMed, Biotechnol Appl Biochem)
    A prognostic model utilizing the RS value was successfully proposed. Meanwhile, we identified PDIA3, PGF, and GRP as novel treatment biomarkers for THCA.
    Journal
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    CD4 (CD4 Molecule) • PDIA3 (Protein Disulfide Isomerase Family A Member 3) • NR1D1 (Nuclear Receptor Subfamily 1 Group D Member 1) • PIK3R3 (Phosphoinositide-3-Kinase Regulatory Subunit 3) • SFTPA1 (Surfactant Protein A1) • ULBP2 (UL16 Binding Protein 2)
    3ms
    A SWI/SNF complex-related genes signature predicts prognosis and immune infiltration in ccRCC with KCNK5 as a novel biomarker. (PubMed, Sci Rep)
    Specifically, KCNK5 overexpression significantly inhibited the proliferation, migration, and invasion capabilities of ccRCC cell lines. Although the precise functional mechanisms of these core genes in ccRCC are not yet fully elucidated, this study provides new insights for the treatment of ccRCC.
    Journal
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    TOP2A (DNA topoisomerase 2-alpha) • PIK3R3 (Phosphoinositide-3-Kinase Regulatory Subunit 3)
    3ms
    Molecular mechanisms and genetic predisposition to osteoarthritis and osteosarcoma through Mendelian inheritance patterns. (PubMed, Discov Oncol)
    This study systematically elucidated the genetic susceptibility mechanisms of osteoarthritis and cellular heterogeneity characteristics of osteosarcoma based on Mendelian genetic principles. The findings provide important insights into understanding the genetic basis and molecular mechanisms of orthopedic diseases, laying a theoretical foundation for precision medicine and targeted therapeutic strategy development.
    Journal • BRCA Biomarker
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    TP53 (Tumor protein P53) • BRCA1 (Breast cancer 1, early onset) • AKT1 (V-akt murine thymoma viral oncogene homolog 1) • PIK3R3 (Phosphoinositide-3-Kinase Regulatory Subunit 3)
    4ms
    Impact of trehalose and hydroxychloroquine on the function of BRAF (V600E)-siRNA in the A375 melanoma cells. (PubMed, Iran J Basic Med Sci)
    TRE, either alone or combined with siRNA, showed limited efficacy and may counteract the apoptotic benefits of HCQ. Conversely, HCQ, whether used alone or in combination with siRNA, enhanced apoptosis, suggesting promise as a potential treatment for melanoma.
    Journal
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    BRAF (B-raf proto-oncogene) • RAF1 (Raf-1 Proto-Oncogene Serine/Threonine Kinase) • CASP3 (Caspase 3) • PIK3R3 (Phosphoinositide-3-Kinase Regulatory Subunit 3)
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    BRAF V600E • BRAF V600
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    hydroxychloroquine
    6ms
    Prognostic Value of MCM3AP-AS1 in Glioma and its Regulatory Effect on Tumor Progression. (PubMed, Neurochem Res)
    Upregulated MCM3AP-AS1 expression in glioma was associated with the poor prognosis of glioma. MCM3AP-AS1 may promote glioma progression by enhancing cell proliferation, migration, and invasion through the miR-23c/PIK3R3 axis.
    Journal
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    PIK3R3 (Phosphoinositide-3-Kinase Regulatory Subunit 3)
    9ms
    Investigating Overlapping Immune-related Genetic Markers in Cholangiocarcinoma and Inflammatory Bowel Disease for Predictive Prognosis. (PubMed, J Immunother)
    This study also predicted potential small molecule drugs that might be effective for the treatment of CHOL, such as Umbralisib and Tamoxifen. In conclusion, this study provides new biomarkers and potential targets for diagnosis, prognosis assessment, and treatment of CHOL and IBD.
    Journal
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    SPP1 (Secreted Phosphoprotein 1) • CCR7 (Chemokine (C-C motif) receptor 7) • OSMR (Oncostatin M Receptor) • PIK3R3 (Phosphoinositide-3-Kinase Regulatory Subunit 3) • S100P (S100 calcium binding protein P)
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    tamoxifen • Ukoniq (umbralisib)
    10ms
    Investigating therapeutic efficacy of dacarbazine and temozolomide, alone and in combination with BRAF (V600E) siRNA in A375 human melanoma cell line. (PubMed, Iran J Basic Med Sci)
    The mean expression of the PIK3R3 gene in siRNA+chemotherapy groups revealed a notable reduction. These findings suggest that the siRNA-transfected treatment groups have the potential to provide therapeutic effects comparable to those of chemotherapy.
    Preclinical • Journal
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    BRAF (B-raf proto-oncogene) • RAF1 (Raf-1 Proto-Oncogene Serine/Threonine Kinase) • CASP3 (Caspase 3) • PIK3R3 (Phosphoinositide-3-Kinase Regulatory Subunit 3)
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    BRAF V600E • BRAF V600
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    temozolomide • dacarbazine
    10ms
    GDC-0084 With Radiation Therapy for People With PIK3CA-Mutated Solid Tumor Brain Metastases or Leptomeningeal Metastases (clinicaltrials.gov)
    P1, N=21, Active, not recruiting, Memorial Sloan Kettering Cancer Center | Trial completion date: Dec 2025 --> Dec 2026 | Trial primary completion date: Dec 2025 --> Dec 2026
    Trial completion date • Trial primary completion date
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    PIK3CA (Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) • PTEN (Phosphatase and tensin homolog) • AKT1 (V-akt murine thymoma viral oncogene homolog 1) • PIK3R1 (Phosphoinositide-3-Kinase Regulatory Subunit 1) • PIK3CG (Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma) • PIK3CD (Phosphatidylinositol-4 5-Bisphosphate 3-Kinase Catalytic Subunit Delta) • PIK3CB (Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta) • INPP4B (Inositol polyphosphate-4-phosphatase type II B) • AKT2 (V-akt murine thymoma viral oncogene homolog 2) • INPP5D (Inositol Polyphosphate-5-Phosphatase D) • PIK3C3 (Phosphatidylinositol 3-Kinase Catalytic Subunit Type 3) • PIK3R2 (Phosphoinositide-3-Kinase Regulatory Subunit 2 ) • PIK3R3 (Phosphoinositide-3-Kinase Regulatory Subunit 3)
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    paxalisib (GDC-0084)
    1year
    'Investigation of miRNAs That Affect the PI3K/AKT/mTOR Signaling Pathway in Endometrial Cancer'. (PubMed, Cell Biochem Biophys)
    These results can shed light on the development of molecular-targeted therapy strategies. Treatment strategies can be developed by designing ASOs, LNAs, miRNA antagomirs, or miRNA sponges for upregulated miR-17-5p, miR-221-3p, and miR-222-3p, and miRNA mimics for downregulated miR-7-5p, miR-145-5p, and miR-206.
    Journal
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    PIK3CA (Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) • PIK3R1 (Phosphoinositide-3-Kinase Regulatory Subunit 1) • MIR155 (MicroRNA 155) • PIK3CD (Phosphatidylinositol-4 5-Bisphosphate 3-Kinase Catalytic Subunit Delta) • PIK3CB (Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta) • MIR21 (MicroRNA 21) • MIR221 (MicroRNA 221) • MIR7 (MicroRNA 7) • MIR17 (MicroRNA 17) • MIR206 (MicroRNA 206) • MIR145 (MicroRNA 145) • MIR222 (MicroRNA 222) • PIK3R3 (Phosphoinositide-3-Kinase Regulatory Subunit 3)