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    BIOMARKER:

    PIK3CG overexpression

    i
    Other names: PIK3CG, Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma, Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma Isoform, Serine/Threonine Protein Kinase PIK3CG, PtdIns-3-Kinase Subunit P110-Gamma, PtdIns-3-Kinase Subunit Gamma, PI3-Kinase Subunit Gamma, PI3Kgamma, P110gamma, P120-PI3K, Phosphatidylinositol-4 5-Bisphosphate 3-Kinase 110 KDa Catalytic Subunit Gamma, Phosphatidylinositol-4 5-Bisphosphate 3-Kinase Catalytic Subunit Gamma Isoform, Phosphatidylin
    Entrez ID:
    5294
    Related biomarkers:
    Expression
    Mutation
    7d
    Overexpression of PIK3CG in Cancer Cells Promotes Lung Cancer Cell Migration and Metastasis Through Enhanced MMPs Expression and Neutrophil Recruitment and Activation. (PubMed, Biochem Genet)
    Two PIK3CG-specific inhibitors, Eganelisib and CAY10505, were used to treat A549 and H1299 cells...Co-culture with neutrophils, soluble extracts of neutrophils and cathepsin G all promoted the migration of lung cancer cells. PIK3CG overexpression in tumor cells significantly promoted the migration and metastasis of lung cancer cell.
    Journal
    |
    PIK3CG (Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma) • CTSG (Cathepsin G)
    |
    PIK3CG expression • PIK3CG overexpression
    |
    eganelisib (IPI-549)
    2years
    Repressing phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma by microRNA-142-3p restrains the progression of hepatocellular carcinoma. (PubMed, Bioengineered)
    PIK3CG overexpression dampened the anti-tumor effect of miR-142-3p. miR-142-3p repressed HCC invasion and intensified apoptosis to restrain HCC by abating the PIK3CG-mediated PI3K/AKT/HIF-1α pathway.
    Journal
    |
    HIF1A (Hypoxia inducible factor 1, alpha subunit) • PIK3CG (Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma) • MIR142 (MicroRNA 142)
    |
    PIK3CG expression • PIK3CG overexpression • miR-142 overexpression