^
    Contact us  to learn more about
    our Premium Content:  News alerts, weekly reports and conference planners
    BIOMARKER:

    PIK3CD overexpression

    i
    Other names: PIK3CD, Phosphatidylinositol-4 5-Bisphosphate 3-Kinase Catalytic Subunit Delta, Phosphatidylinositol 4 5-Bisphosphate 3-Kinase Catalytic Subunit Delta Isoform, PtdIns-3-Kinase Subunit P110-Delta, Phosphoinositide-3-Kinase C, PI3Kdelta, Phosphatidylinositol-4 5-Bisphosphate 3-Kinase Catalytic Subunit Delta Short Variant 8/20, Phosphatidylinositol-4 5-Bisphosphate 3-Kinase Catalytic Subunit Delta Short Variant 20, Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Delta Short Variant
    Entrez ID:
    5293
    Related biomarkers:
    Expression
    Mutation
    over1year
    SELINEXOR COMBINED WITH CX-4945 PROMOTES CELL DEATH BY TARGETING PIK3CD/AKT1/FOXO3 SIGNALING IN ACUTE MYELOID LEUKEMIA (EHA 2023)
    Our data demonstrated for the first time the synergistic effect of a novel combination of KPT-330 and CX-4945 on cell growth arrest and apoptosis in AML cells, and identify the underlying mechanism bytargeting the PIK3CD/AKT1/FOXO3 signaling pathway, which highlighted the feasibility of clinical trials for combination therapy of AML patients.
    IO biomarker
    |
    PIK3CD (Phosphatidylinositol-4 5-Bisphosphate 3-Kinase Catalytic Subunit Delta) • ANXA5 (Annexin A5)
    |
    PIK3CD expression • PIK3CD overexpression
    |
    Xpovio (selinexor) • silmitasertib (CX-4945)