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BIOMARKER:

PIK3CD overexpression

i
Other names: PIK3CD, Phosphatidylinositol-4 5-Bisphosphate 3-Kinase Catalytic Subunit Delta, Phosphatidylinositol 4 5-Bisphosphate 3-Kinase Catalytic Subunit Delta Isoform, PtdIns-3-Kinase Subunit P110-Delta, Phosphoinositide-3-Kinase C, PI3Kdelta, Phosphatidylinositol-4 5-Bisphosphate 3-Kinase Catalytic Subunit Delta Short Variant 8/20, Phosphatidylinositol-4 5-Bisphosphate 3-Kinase Catalytic Subunit Delta Short Variant 20, Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Delta Short Variant
Entrez ID:
Related biomarkers:
11ms
SELINEXOR COMBINED WITH CX-4945 PROMOTES CELL DEATH BY TARGETING PIK3CD/AKT1/FOXO3 SIGNALING IN ACUTE MYELOID LEUKEMIA (EHA 2023)
Our data demonstrated for the first time the synergistic effect of a novel combination of KPT-330 and CX-4945 on cell growth arrest and apoptosis in AML cells, and identify the underlying mechanism bytargeting the PIK3CD/AKT1/FOXO3 signaling pathway, which highlighted the feasibility of clinical trials for combination therapy of AML patients.
IO biomarker
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PIK3CD (Phosphatidylinositol-4 5-Bisphosphate 3-Kinase Catalytic Subunit Delta) • ANXA5 (Annexin A5)
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PIK3CD expression • PIK3CD overexpression
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Xpovio (selinexor) • silmitasertib (CX-4945)