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    BIOMARKER:

    PIK3CA mutation + HER-2 amplification

    i
    Other names: PIK3CA, Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha, Phosphoinositide-3-kinase, catalytic, alpha polypeptide, Serine/threonine protein kinase PIK3CA, PtdIns-3-kinase subunit P110-alpha, PI3K-alpha, Phosphatidylinositol-4,5-bisphosphate 3-kinase 110 KDa catalytic subunit alpha, Phosphatidylinositol 3-kinase, Catalytic, 110-KD, alpha, PI3-kinase P110 subunit alpha, PI3-kinase subunit alpha, PtdIns-3-kinase subunit alpha, PI3Kalpha, P110alpha, PI3K,ERBB2, CD340, HER-2, HE
    Entrez ID:
    2064; 5290
    Related biomarkers:
    Expression
    Mutation
    CNA
    Fusion
    Others
    over4years
    [VIRTUAL] ONC201 induces apoptosis in gastric adenocarcinoma and exhibits synergy with rhTRAIL (AACR-II 2020)
    We are further exploring the role of ONC201 in priming cells via up-regulation of DR5 receptors such that they have increased sensitivity to rhTRAIL when pretreated with ONC201 as a potential source for the established synergy in gastric adenocarcinoma cells. We will also apply this study regimen to an organoid and in vivo model.
    PARP Biomarker
    |
    HER-2 (Human epidermal growth factor receptor 2) • PIK3CA (Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) • MSI (Microsatellite instability) • CDH1 (Cadherin 1) • CASP8 (Caspase 8) • FOXO3 (Forkhead box O3)
    |
    TP53 mutation • HER-2 amplification • PIK3CA amplification • PIK3CA mutation + HER-2 amplification
    |
    dordaviprone (ONC201)