Checkpoint inhibition • Tumor mutational burden • PD(L)-1 Biomarker • IO biomarker
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TP53 (Tumor protein P53) • PIK3CA (Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) • TMB (Tumor Mutational Burden) • HLA-A (Major Histocompatibility Complex, Class I, A) • KMT2D (Lysine Methyltransferase 2D) • B2M (Beta-2-microglobulin) • MUC16 (Mucin 16, Cell Surface Associated) • HLA-B (Major Histocompatibility Complex, Class I, B) • PRKDC (Protein Kinase, DNA-Activated, Catalytic Subunit) • HLA-C (Major Histocompatibility Complex, Class I, C) • UBR5 (Ubiquitin Protein Ligase E3 Component N-Recognin 5)
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TMB-H • PIK3CA mutation • TMB-L • PIK3CA expression • PIK3CA wild-type
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ACTOnco