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    GENE:

    PICALM (Phosphatidylinositol Binding Clathrin Assembly Protein)

    i
    Other names: PICALM, Phosphatidylinositol Binding Clathrin Assembly Protein, CALM, Phosphatidylinositol-Binding Clathrin Assembly Protein, Clathrin Assembly Lymphoid Myeloid Leukemia Protein, CLTH, PICALM, LAP
    Associations

    News

    Trials
    over1year
    PICALM Regulating the Generation of Amyloid β-Peptide to Promote Anthracycline-Induced Cardiotoxicity. (PubMed, Adv Sci (Weinh))
    This alleviates the doxorubicin-induced cardiotoxicity in vitro and in vivo. In human heart tissue samples of patients with chemotherapy-induced cardiotoxicity, PICALM, and amyloid β-peptide are elevated as well.
    Journal
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    PICALM (Phosphatidylinositol Binding Clathrin Assembly Protein)
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    doxorubicin hydrochloride
    over2years
    Altered granulocyte count and erythrocyte measures in middle-aged, healthy carriers of APOE and PICALM risk genes for Alzheimer's disease. (PubMed, Acta Neurobiol Exp (Wars))
    No other differences in blood count or lipoprotein profile were found between healthy APOE/PICALM risk‑carriers and non-risk carriers. Longitudinal studies will reveal if and how those changes contribute to the development of AD pathology.
    Journal
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    APOE (Apolipoprotein E) • PICALM (Phosphatidylinositol Binding Clathrin Assembly Protein)
    almost4years
    PICALM exerts a role in promoting CRC progression through ERK/MAPK signaling pathway. (PubMed, Cancer Cell Int)
    In summary, the study presented the new discovery that PICALM promoted CRC progression through ERK/MAPK signaling pathway, which drew further interest regarding its clinical application as a promising therapeutic target.
    Journal
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    MAP2K1 (Mitogen-activated protein kinase kinase 1) • PICALM (Phosphatidylinositol Binding Clathrin Assembly Protein)