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    BIOMARKER:

    PHLPP1 mutation

    i
    Other names: PHLPP1, PH Domain And Leucine Rich Repeat Protein Phosphatase 1, Pleckstrin Homology Domain Containing, Family E (With Leucine Rich Repeats) Member 1, PH Domain Leucine-Rich Repeat-Containing Protein Phosphatase 1, Suprachiasmatic Nucleus Circadian Oscillatory Protein Protein Phosphatase, Mg2+/Mn2+ Dependent 3A, PH Domain-Containing Family E Member 1, PLEKHE1, PHLPP, SCOP, Pleckstrin Homology Domain-Containing Family E Member 1, PH Domain And Leucine Rich Repeat Protein Phosphatase, SCN Circadi
    Entrez ID:
    23239
    Related biomarkers:
    CNA
    over2years
    Downregulation of PHLPP induced by endoplasmic reticulum stress promotes eIF2α phosphorylation and chemoresistance in colon cancer. (PubMed, Cell Death Dis)
    Functionally, knockdown of PHLPP improved cell survival under ER stress conditions, whereas overexpression of a degradation-resistant mutant PHLPP1 had the opposite effect. Taken together, our studies identified ER stress as a novel mechanism that triggers PHLPP downregulation; and PHLPP-loss promotes chemoresistance by upregulating the eIF2α/ATF4 signaling axis in colon cancer cells.
    Journal
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    PHLPP1 (PH Domain And Leucine Rich Repeat Protein Phosphatase 1) • ATF4 (Activating Transcription Factor 4)
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    PHLPP1 mutation