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GENE:

PHLDA1 (Pleckstrin Homology Like Domain Family A Member 1)

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Other names: PHLDA1, Pleckstrin Homology Like Domain Family A Member 1, TDAG51, PHRIP, DT1P1B11, Pleckstrin Homology-Like Domain Family A Member 1, T-Cell Death-Associated Gene 51 Protein, Apoptosis-Associated Nuclear Protein, Proline- And Glutamine-Rich Protein, Proline- And Histidine-Rich Protein, Proline-Histidine Rich Protein, PQ-Rich Protein, PQR Protein, Pleckstrin Homology-Like Domain, Family A, Member 1
Associations
Trials
10ms
Fibrofolliculoma/Trichodiscoma With Focal Follicular Germinative Cell Differentiation. (PubMed, J Cutan Pathol)
Based on these findings, we diagnosed this tumor as FF/TD with focal follicular germinative cell differentiation. It provides valuable insights into the origin and disease concept of these tumors.
Journal
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PHLDA1 (Pleckstrin Homology Like Domain Family A Member 1)
11ms
Single-cell sequencing reveals PHLDA1-positive smooth muscle cells promote local invasion in head and neck squamous cell carcinoma. (PubMed, Transl Oncol)
PHLDA1-positive smooth muscle cells play a critical role in head and neck squamous cell carcinoma invasion through THBS1. Targeting PHLDA1-positive smooth muscle cells or THBS1 may offer a promising therapeutic approach for head and neck squamous cell carcinoma treatment.
Journal
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SDC1 (Syndecan 1) • PHLDA1 (Pleckstrin Homology Like Domain Family A Member 1)
over1year
Multiple Machine Learning Identifies Key Gene PHLDA1 Suppressing NAFLD Progression. (PubMed, Inflammation)
Our study reveals that PHLDA1 inhibits the progression of NAFLD, as overexpression of PHLDA1 significantly reduces lipid accumulation in cells and markedly decreases the expression of key molecules involved in liver lipogenesis and fatty acid uptake. Therefore, PHLDA1 may emerge as a novel potential target for future prediction, diagnosis, and targeted prevention of NAFLD.
Journal • Machine learning
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CD36 (thrombospondin receptor) • FASN (Fatty acid synthase) • PHLDA1 (Pleckstrin Homology Like Domain Family A Member 1)
almost3years
PHLDA1 is a P53 target gene involved in P53-mediated cell apoptosis. (PubMed, Mol Cell Biochem)
Finally, a series of gain-of-function experiments further confirmed that p53 re-expression in HeLa cell can up-regulate the reduction of PHLDA1 caused by p53 knockout, and affect cell apoptosis and proliferation. Our study is the first to explore the regulatory mechanism of p53 on PHLDA1 by using the p53 gene knockout cell model, which further proves that PHLDA1 is a target-gene in p53-mediated apoptosis, and reveals the important role of PHLDA1 in cell fate determination.
Journal
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PHLDA1 (Pleckstrin Homology Like Domain Family A Member 1)
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TP53 expression
almost3years
HDAC Inhibition Restores Response to HER2-Targeted Therapy in Breast Cancer via PHLDA1 Induction. (PubMed, Int J Mol Sci)
Critically, we show that when given in combination, 4SC-202 and lapatinib exert synergistic effects on 2D cell proliferation and colony formation capacity. We therefore propose that co-treatment with 4SC-202 may prolong the clinical efficacy of lapatinib in HER2 breast cancer patients.
Journal
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HER-2 (Human epidermal growth factor receptor 2) • PHLDA1 (Pleckstrin Homology Like Domain Family A Member 1)
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lapatinib • domatinostat (4SC-202)
over3years
Research Progress of Pleckstrin Homology Like Domain Family A Member 1 in Tumor (PubMed, Zhongguo Yi Xue Ke Xue Yuan Xue Bao)
Pleckstrin homology like domain family A member 1(PHLDA1) is also known as T-cell death-associated gene 51 (TDAG51).Studies have demonstrated that the abnormal expression of PHLDA1 is closely associated with the formation,development,and metastasis of tumors.We summarized the latest research advances in the structure and biological properties of PHLDA1,as well as the roles of PHLDA1 in multiple malignanttumors such as breast cancer,cancer,liver gastric cancer,liver cancer,melanoma,and osteosarcoma,aiming to comprehensively reveal the significance of PHLDA1 in the clinical diagnosis of tumors.
Journal
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PHLDA1 (Pleckstrin Homology Like Domain Family A Member 1)