phenelzine

Our investigations reveal that alterations in gut microbial composition leading to increased 5-HIAA synthesis can negatively impact CD8+ T cell functionality and the success of immunotherapy. The combination of Phe and AKK supplementation holds potential for optimizing immunotherapy efficacy.

Through drug repurposing, 81 candidate drugs were found to be effective against these markers genes, with Diosmin, Esculin, Lapatinib, and Phenelzine as the best candidates screened through molecular docking and MMGBSA. The consensus derived from multiple methods enhances the accuracy of identifying relevant robust biomarkers for NAFLD-associated HCC. The use of these biomarkers in a multiphase drug repurposing strategy highlights potential therapeutic options for early intervention, which is essential to stop disease progression and improve outcomes.

These effects were significantly influenced by the concentration of available serotonin. Conclusions Our study demonstrates that various mechanisms, including AHR activation, modulation of reactive oxygen and nitrogen species production, and others, in addition to the increased availability of serotonin due to phenelzine treatment, can significantly influence the inflammatory state.

P4, N=150, Enrolling by invitation, University of California, San Francisco | Not yet recruiting --> Enrolling by invitation

P4, N=150, Not yet recruiting, University of California, San Francisco

A Phase II Clinical Trial has demonstrated the therapeutic effects of the irreversible nonselective MAOi phenelzine for prostate cancer...However, introduction of a polar 2-hydroxy in the propyl chain retained the highly selective MAOA inhibition and cancer cell cytotoxicity of clorgyline while reducing its CNS score from 2 to 0. We believe that these results identify a new class of peripherally directed MAOIs that may allow safer therapeutic targeting of MAOA for a variety of anti-cancer and anti-inflammatory indications.

P2, N=26, Completed, University of Southern California | Active, not recruiting --> Completed

KDM1A is a regulator of cellular UV response, and KDM1A inhibition can improve PDT efficacy.

Our findings suggest that Enz-increased ARv7 expression can transcriptionally enhance MAO-A expression resulting in Enz resistance via altering the hypoxia HIF-1α signals. Together, our results show that targeting the Enz/ARv7/MAO-A signaling with the antidepressants phenelzine or clorgyline can restore Enz sensitivity to suppress EnzR cell growth, which may indicate that these antidepression drugs can overcome the Enz resistance to further suppress the EnzR CRPC.