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DRUG:

durcabtagene autoleucel (PHE885)

i
Other names: PHE885, PHE-885, PHE 885
Associations
Trials
Company:
Novartis
Drug class:
BCMA-targeted CAR-T immunotherapy
Related drugs:
Associations
Trials
2d
PHE885 CAR-T Therapy in Adult Participants With Relapsed and Refractory Multiple Myeloma (clinicaltrials.gov)
P2, N=146, Active, not recruiting, Novartis Pharmaceuticals | Trial completion date: Dec 2025 --> Feb 2025 | Trial primary completion date: Dec 2025 --> Feb 2025
Trial completion date • Trial primary completion date
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durcabtagene autoleucel (PHE885)
8ms
PHE885 CAR-T Therapy in Adult Participants With Relapsed and Refractory Multiple Myeloma (clinicaltrials.gov)
P2, N=136, Recruiting, Novartis Pharmaceuticals | Active, not recruiting --> Recruiting
Enrollment open • CAR T-Cell Therapy
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durcabtagene autoleucel (PHE885)
10ms
PHE885 CAR-T Therapy in Adult Participants With Relapsed and Refractory Multiple Myeloma (clinicaltrials.gov)
P2, N=136, Active, not recruiting, Novartis Pharmaceuticals | Recruiting --> Active, not recruiting
Enrollment closed • CAR T-Cell Therapy
|
durcabtagene autoleucel (PHE885)
10ms
BCMA-directed CAR-T Cell Therapy in Adult Patients With Multiple Myeloma (clinicaltrials.gov)
P1, N=96, Active, not recruiting, Novartis Pharmaceuticals | Recruiting --> Active, not recruiting
Enrollment closed • CAR T-Cell Therapy
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durcabtagene autoleucel (PHE885)
1year
T-Charge™ Manufacturing of the Anti-BCMA CAR-T, Durcabtagene Autoleucel (PHE885), Promotes Expansion and Persistence of CAR-T Cells with High TCR Repertoire Diversity (ASH 2023)
Our findings demonstrate that the T-Charge™ manufacturing platform successfully maintains highly heterogeneous transduced Tscm clones with self-renewal potential in durcabtagene autoleucel products. Maintenance of Tscm in manufactured products contributes to robust CAR-T expansion and long-term persistence of CAR-T cells with a highly diverse TCR repertoire after infusion.
CAR T-Cell Therapy • IO biomarker
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CD8 (cluster of differentiation 8) • CD4 (CD4 Molecule)
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CD8 positive • CD4 positive • CD8 negative
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durcabtagene autoleucel (PHE885)
3years
Identification and Development of PHE885: A Novel and Highly Potent Fully Human Anti-BCMA CAR-T Manufactured with a Novel T-ChargeTM Platform for the Treatment of Multiple Myeloma (ASH 2021)
In addition to its unique phenotype, PHE885 secretes up to 25 fold more target specific IL-2 and ~7 fold more IFN gamma in vitro , when comparing to the TM products either using the same lentiviral vector (TM_PHE885) or a clinically validated anti-BCMA vector (MCM998) . Based on these results, a Phase 1, open-label trial assessing PHE885 in patients with r/r MM (NCT04318327) was initiated. Initial data from the dose escalation portion of the Phase 1 study will be presented separately.
IO biomarker
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IFNG (Interferon, gamma) • IL2RA (Interleukin 2 receptor, alpha) • TNFRSF9 (TNF Receptor Superfamily Member 9) • CCR7 (Chemokine (C-C motif) receptor 7)
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MCM998 • durcabtagene autoleucel (PHE885)