PGR (Progesterone receptor)

Present findings are from a small sample cohort and need further validation from a larger cohort. The online version contains supplementary material available at 10.1007/s13193-025-02427-0.

The calibration curves indicated good agreement and DCA confirmed the clinical utility of the model. The proposed nomogram demonstrated robust predictive performance for patients with breast cancer and liver metastases and may provide valuable prognostic information, pending further validation.

These underscore the relevance of age-related biological factors in shaping breast cancer characteristics. However, among Indonesian women over 45 years old, the proportion of high breast density remains remarkably high (65.6%), suggesting that factors beyond age-such as genetic, hormonal, or lifestyle influences-may contribute to the persistence of dense breast tissue in this population.

This approach offers a promising, non-invasive alternative to traditional tissue sampling by enabling a "digital biopsy." Integrating these models into clinical workflows could reduce the diagnostic burden on patients and facilitate personalized treatment planning. However, further validation in larger, prospective cohorts is necessary.

In summary, high glucose may promote the progression of PR-negative EC by downregulating CD146 expression and inducing EMT, suggesting that CD146 represents a promising therapeutic target for precision treatment strategies in EC, particularly in patients with concurrent glucose metabolism dysregulation.

P2, N=88, Active, not recruiting, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | Trial completion date: Jun 2026 --> Jun 2027

We discuss key lncRNAs implicated in TNBC pathogenesis and their potential as diagnostic biomarkers, prognostic indicators and therapeutic targets. By elucidating the complex interplay between lncRNAs and oncogenic pathways, this review underscores the promise of lncRNA-based strategies in improving TNBC management and patient outcomes.

P=N/A, N=1950, Recruiting, Ruijin Hospital | Not yet recruiting --> Recruiting

The precise role of hormones in OSCC has been less explored in the literature. Therefore, the significant expression of ERα and PR observed in dysplastic and OSCC groups in this study may elucidate their roles in tumor development and progression.

This study demonstrates the feasibility and clinical potential of non-invasive molecular profiling of BCBMs using a multi-modal DL approach. These findings might offer a promising tool for treatment planning and patient management, reducing the need for invasive biopsies while enabling more accurate and comprehensive molecular characterization of brain metastases.

These findings suggest that associations between dietary phytoestrogen intake and breast cancer may vary across receptor-defined subtypes and highlight the need for replication using biomarker-based measures and populations with higher exposure levels.

P3, N=1615, Active, not recruiting, Jiangsu HengRui Medicine Co., Ltd. | Recruiting --> Active, not recruiting