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    BIOMARKER:

    PER3 mutation

    i
    Other names: PER3, Period Circadian Regulator 3, Cell Growth-Inhibiting Gene 13 Protein, Period Circadian Protein Homolog 3, Circadian Clock Protein PERIOD 3, Period Circadian Clock 3, Period (Drosophila) Homolog 3, Period Homolog 3 (Drosophila), Period Circadian Protein 3, FASPS3, GIG13, HPER3
    Entrez ID:
    8863
    almost3years
    The PER3 SNP induces pigmentation phenotypes of dyschromatosis universalis hereditaria. (PubMed, J Mol Med (Berl))
    SASH1 mutation is confirmed to associate with DUH. A novel autosomal dominant inheritance DUH subtype with mild pigmentated phenotypes is caused by the PER3 SNP.
    Journal
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    ABCB6 (ATP Binding Cassette Subfamily B Member 6 (Langereis Blood Group)) • PER3 (Period Circadian Regulator 3) • SASH1 (SAM And SH3 Domain Containing 1)
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    PER3 mutation
    almost4years
    Alterations of the circadian clock genes and their association with tumor mutation burden and response to immunotherapy in NSCLC (AACR 2022)
    Our data indicated that mutations in the clock genes were associated with higher TMB and improved clinical outcomes in NSCLC patients treated with ICIs, suggesting that these mutations might be a potential predictive biomarker for ICIs treatment in NSCLC. However, they did not have significant prognostic value.
    Tumor Mutational Burden • PD(L)-1 Biomarker • IO biomarker
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    PD-L1 (Programmed death ligand 1) • TMB (Tumor Mutational Burden) • PER2 (Period Circadian Regulator 2) • CRY1, Cryptochrome Circadian Regulator 1, • ARNTL (Aryl Hydrocarbon Receptor Nuclear Translocator Like) • CLOCK (Clock Circadian Regulator) • PER1 (Period Circadian Clock 1) • PER3 (Period Circadian Regulator 3)
    |
    PD-L1 expression • TMB-H • CLOCK mutation • PER3 mutation