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    BIOMARKER:

    PDX1 mutation

    i
    Other names: PDX1, Pancreatic And Duodenal Homeobox 1, IDX-1, STF-1, PDX-1, Islet/Duodenum Homeobox-1, Insulin Upstream Factor 1, Glucose-Sensitive Factor, MODY4, IUF-1, IPF1, GSF, Insulin Promoter Factor 1, Homeodomain Transcription Factor, Somatostatin-Transactivating Factor 1, Pancreas/Duodenum Homeobox Protein 1, Somatostatin Transcription Factor 1, IPF-1, Pancreatic-Duodenal Homeobox Factor 1, Insulin Promoter Factor 1, PAGEN1, IUF1, STF1
    Entrez ID:
    3651
    9ms
    Generation of allogenic chimera carrying mutations in PDX1 and TP53 genes via phytohemagglutinin-mediated blastomere aggregation in pigs. (PubMed, In Vitro Cell Dev Biol Anim)
    Two out of three fetuses carried only the PDX1 mutation, indicating that the fetuses developed from embryos not carrying TP53-edited blastomeres. The results of the present study could facilitate the further improvement and design of high-frequency developing pancreatic tumor models in pigs.
    Journal
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    TP53 (Tumor protein P53) • PDX1 (Pancreatic And Duodenal Homeobox 1)
    |
    TP53 mutation • PDX1 mutation
    1year
    CD38-Directed, Single-Chain T Cell-Engager Targets Leukemia Stem Cells through IFNγ-Induced CD38 Expression (ASH 2023)
    In sum, BN-CD38 induces an effective T cell synapse and IFNγ release, while concomitantly blocking the clonogenicity and inducing CD38 expression on LSCs. These studies suggest a new mechanism to unmask and target LSCs, providing the rationale for using BN-CD38 to effectively treat AML.
    IO biomarker
    |
    TP53 (Tumor protein P53) • CD8 (cluster of differentiation 8) • IFNG (Interferon, gamma) • CD38 (CD38 Molecule) • IL2RA (Interleukin 2 receptor, alpha) • CD34 (CD34 molecule) • CD69 (CD69 Molecule) • IRF1 (Interferon Regulatory Factor 1) • GLI2 (GLI Family Zinc Finger 2) • PDX1 (Pancreatic And Duodenal Homeobox 1)
    |
    TP53 mutation • CD38 expression • IFNG expression • IRF1 expression • CD38 overexpression • PDX1 mutation