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GENE:

PDP1 (Pyruvate Dehydrogenase Phosphatase Catalytic Subunit 1)

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14d

PDP1 drives hepatocellular carcinoma progression by regulating senescence through the cAMP/Ca2+ signaling pathway. (PubMed, Biochem Pharmacol)

Importantly, glycolysis inhibition restores senescence and reverses PDP1-driven malignant phenotypes. Collectively, these findings identify that PDP1 drives senescence-associated malignant progression in HCC by linking glycolytic regulation, histone lactylation, and DNA methylation to the control of ADCY5 expression and subsequent cAMP/Ca2+ signaling, underscoring its potential as a therapeutic target.

14 days ago

Journal

DNMT1 (DNA methyltransferase 1) • CDKN1A (Cyclin-dependent kinase inhibitor 1A) • PDP1 (Pyruvate Dehydrogenase Phosphatase Catalytic Subunit 1)

4ms

BACH1 promotes hepatocellular carcinoma progression by targeting PDP1 towards the PI3K-AKT-mTOR signaling activation. (PubMed, Bioorg Chem)

Downregulation of either BACH1 or PDP1 suppressed the PI3K-AKT-mTOR signaling pathway, and a PI3K activator effectively reversed the inhibition of HCC cell proliferation induced by BACH1 or PDP1 downregulation. Collectively, our present study reveals a novel regulatory axis of BACH1-PDP1-PI3K-AKT-mTOR, thereby providing potential intervention targets and a theoretical basis for the molecular precision therapy of HCC.

4 months ago

Journal

BRIP1 (BRCA1 Interacting Protein C-terminal Helicase 1) • BACH1 (BTB Domain And CNC Homolog 1) • PDP1 (Pyruvate Dehydrogenase Phosphatase Catalytic Subunit 1)

6ms

Targeting pyruvate metabolism generates distinct CD8+ T cell responses to gammaherpesvirus and B lymphoma. (PubMed, JCI Insight)

Importantly, CD8+ T cell populations after B cell lymphoma challenge were smaller in both groups, resulting in poorer protection, which was rescued by glutamine and acetate supplementation. Overall, this study indicates that PDK1 and PDP1 both enhance metabolic capacity, but the context of the antigenic challenge significantly influences the consequences for T cell function.

6 months ago

Journal

CD8 (cluster of differentiation 8) • PDP1 (Pyruvate Dehydrogenase Phosphatase Catalytic Subunit 1)

8ms

Additionally, KIF23, TRMT5, TEFM, SLC25A13, TIMM50, DGUOK, DNM1L and COX5A exhibited trends consistent with expectations in the two ESCC cell lines. This study identified six hub genes relevant to ESCC, offering a theoretical foundation for potential therapeutic approaches in ESCC.

8 months ago

Journal • Gene Signature

KIF23 (Kinesin Family Member 23) • PDP1 (Pyruvate Dehydrogenase Phosphatase Catalytic Subunit 1)

9ms

Emerging roles of pyruvate dehydrogenase phosphatase 1: a key player in metabolic health. (PubMed, Front Physiol)

Emerging research suggests that it is involved in various diseases, including pancreatic ductal adenocarcinoma, cardiomyogenesis defects, traumatic brain injury, and Barth syndrome. In this review, we discuss recent studies revealing the crucial role of PDP1 and its dysregulation in various metabolic disorders, thereby highlighting its potential as a therapeutic target for these debilitating diseases.

9 months ago

Review • Journal

PDP1 (Pyruvate Dehydrogenase Phosphatase Catalytic Subunit 1)

9ms

Comprehensive analysis and experiment validation of five cuproptosis-related genes in prognosis, immune infiltration and metabolic characterization of pancreatic cancer. (PubMed, PLoS One)

Five CRGs relevant to pancreatic cancer prognosis were identified. Meanwhile, a new and accurate five CRGs prognostic model of pancreatic cancer was constructed. In addition, LIPT1 may promote proliferation, invasion and migration of pancreatic cancer cell lines. This may have a specific guiding value for future development of precise anti-cancer treatment strategies.

9 months ago

Journal

CD4 (CD4 Molecule) • DLAT (Dihydrolipoamide S-Acetyltransferase) • LIAS (Lipoic Acid Synthetase) • LIPT1 (Lipoyltransferase 1) • PDP1 (Pyruvate Dehydrogenase Phosphatase Catalytic Subunit 1)

10ms

ACSL1, BNIP3, and EMC2 were downregulated after knockdown of PDP1. RiskScore model constructed by PDP1-ferroptosis-related genes ACSL1, BNIP3, and EMC2 is able to help predict the prognosis of BC patients.

10 months ago

Journal

PDP1 (Pyruvate Dehydrogenase Phosphatase Catalytic Subunit 1) • ACSL1 (Acyl-CoA Synthetase Long Chain Family Member 1)

10ms

Identification of oxidative stress-related subgroups and signature genes for the prediction of prognosis and immune microenvironment in thyroid cancer. (PubMed, Mol Genet Genomics)

This study provided a novel oxidative stress-related classification system for THCA, highlighting key signature genes with prognostic and therapeutic relevance. These results may guide future research on oxidative stress-targeted therapies and immune modulation in THCA.

10 months ago

Journal

BRAF (B-raf proto-oncogene) • TP53 (Tumor protein P53) • CD8 (cluster of differentiation 8) • BMI1 (BMI1 proto-oncogene, polycomb ring finger) • IL1RN (Interleukin 1 receptor antagonist) • PDP1 (Pyruvate Dehydrogenase Phosphatase Catalytic Subunit 1)

BRAF mutation

11ms

Thermally Activated On-Surface Self-Metalation of Pd-Phthalocyanines. (PubMed, Chemistry)

Additionally, Near-Edge X-Ray Absorption Fine Structure (NEXAFS) reveals that no desorption or chemical degradation occurs during the process. We believe this study represents a significant step forward in the scalable synthesis of PdPc, which, like other Pd-containing organic molecules, holds great potential for applications in catalysis and cancer therapy.

11 months ago

Journal

PDP1 (Pyruvate Dehydrogenase Phosphatase Catalytic Subunit 1)

over1year

PDP1 promotes KRAS mutant colorectal cancer progression by serving as a scaffold for BRAF and MEK1. (PubMed, Cancer Lett)

Crucially, targeting PDP1 combined with MAPK inhibitors exhibits an obvious inhibitory effect on KRAS mutant CRC. Overall, PDP1 is underscored as a vital oncogenic driver and promising therapeutic target for KRAS mutant CRC.

over 1 year ago

Journal

KRAS (KRAS proto-oncogene GTPase) • BRAF (B-raf proto-oncogene) • MAP2K1 (Mitogen-activated protein kinase kinase 1) • PDP1 (Pyruvate Dehydrogenase Phosphatase Catalytic Subunit 1)

Lumakras (sotorasib)

over1year

Defining three ferroptosis-based molecular subtypes and developing a prognostic risk model for high-grade serous ovarian cancer. (PubMed, Aging (Albany NY))

Our results could improve the understanding of ferroptosis in OV, providing promising insights for the clinical targeted therapy for the cancer.

over 1 year ago

Journal • IO biomarker

CD8 (cluster of differentiation 8) • LAG3 (Lymphocyte Activating 3) • CD276 (CD276 Molecule) • CTLA4 (Cytotoxic T-Lymphocyte Associated Protein 4) • TIGIT (T Cell Immunoreceptor With Ig And ITIM Domains 2) • IDO1 (Indoleamine 2,3-dioxygenase 1) • CXCL9 (Chemokine (C-X-C motif) ligand 9) • ICOS (Inducible T Cell Costimulator) • CD27 (CD27 Molecule) • GAS1 (Growth Arrest Specific 1) • SLC7A11 (Solute Carrier Family 7 Member 11) • EPHA4 (EPH Receptor A4) • PDP1 (Pyruvate Dehydrogenase Phosphatase Catalytic Subunit 1)

cisplatin • gefitinib • gemcitabine

almost2years

PDP1 promotes the progression of breast cancer through STAT3 pathway. (PubMed, Cell Biochem Funct)

Cell counting kit-8 assay showed that PDP1 overexpression significantly raised MDA-MB-231 and MCF7 cell viability while STAT3 inhibitor S3I-201 recovered the cell growth to normal level. To summarize, PDP1 promotes the progression of BC through STAT3 pathway by regulating p-STAT3. The findings contribute to understanding the molecular mechanisms underlying BC progression, and opening avenues for targeted therapeutic approaches.

almost 2 years ago

Journal

PDP1 (Pyruvate Dehydrogenase Phosphatase Catalytic Subunit 1)

PD-1-L • STAT3 overexpression

GLG-302