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    BIOMARKER:

    PDIA6 overexpression

    i
    Other names: PDIA6, Protein Disulfide Isomerase Family A Member 6, P5, TXNDC7, ERp5, Thioredoxin Domain Containing 7 (Protein Disulfide Isomerase), Protein Disulfide Isomerase-Related Protein, Protein Disulfide Isomerase-Associated 6, Thioredoxin Domain-Containing Protein 7, Endoplasmic Reticulum Protein 5, Protein Disulfide-Isomerase A6, Protein Disulfide Isomerase P5, ER Protein 5, ERP5, Protein Disulfide Isomerase Family A, Member 6, Epididymis Secretory Sperm Binding Protein
    Entrez ID:
    10130
    almost2years
    The SOX2/PDIA6 axis mediates aerobic glycolysis to promote stemness in non-small cell lung cancer cells. (PubMed, J Bioenerg Biomembr)
    Further experiments revealed that PDIA6 overexpression restored repressive effect of knocking down SOX2 on aerobic glycolysis and cell stemness. This work revealed that the SOX2/PDIA6 axis mediated aerobic glycolysis to promote NSCLC cell stemness, providing new therapeutic strategies for NSCLC.
    Journal
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    SOX2 • PDIA6 (Protein Disulfide Isomerase Family A Member 6)
    |
    PDIA6 overexpression • SOX2 expression