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    BIOMARKER:

    PDGFRB overexpression

    i
    Other names: PDGFRB, Platelet Derived Growth Factor Receptor Beta, Platelet-Derived Growth Factor Receptor, Beta Polypeptide, Beta-Type Platelet-Derived Growth Factor Receptor, Platelet-Derived Growth Factor Receptor Beta, Platelet-Derived Growth Factor Receptor 1, CD140 Antigen-Like Family Member B, PDGF-R-Beta, PDGFR-Beta, PDGFR-1, PDGFR1,Beta Platelet-Derived Growth Factor Receptor, Activated Tyrosine Kinase PDGFRB, CD140b Antigen, NDEL1-PDGFRB , CD140B, IBGC4, JTK12, PENTT, IMF1 , KOGS
    Entrez ID:
    5159
    Related biomarkers:
    Expression
    Mutation
    Fusion
    Others
    8d
    PDGFRB promotes dedifferentiation and pulmonary metastasis through rearrangement of cytoskeleton under hypoxic microenvironment in osteosarcoma. (PubMed, Cell Signal)
    Our results demonstrated that HIF1A up-regulated PDGFRB under hypoxic conditions, and PDGFRB regulated the actin cytoskeleton, a process likely linked to the activation of RhoA and the phosphorylation of, thereby promoting OS dedifferentiation and pulmonary metastasis.
    Journal
    |
    PDGFRB (Platelet Derived Growth Factor Receptor Beta) • HIF1A (Hypoxia inducible factor 1, alpha subunit) • RHOA (Ras homolog family member A) • VCL (Vinculin)
    |
    PDGFRB overexpression • HIF1A expression
    over4years
    [VIRTUAL] Pancancer proteomic investigation identifies overexpressed kinases as novel cancer dependent targets (AACR-II 2020)
    Finally, we demonstrated that a subset of HCC mouse models that overexpressed PDGFRB -as detected in parallel in human HCC cohorts- could be specifically treated by a receptor tyrosine kinase inhibitor. Overall, our results suggest that proteomic-level alterations not readily observed by genomics represent cancer vulnerabilities that need to be carefully considered as potential targets for personalized treatments.
    Late-breaking abstract • Pan tumor
    |
    EGFR (Epidermal growth factor receptor) • HER-2 (Human epidermal growth factor receptor 2) • FGFR1 (Fibroblast growth factor receptor 1) • PDGFRA (Platelet Derived Growth Factor Receptor Alpha) • PDGFRB (Platelet Derived Growth Factor Receptor Beta) • CDK6 (Cyclin-dependent kinase 6) • AKT2 (V-akt murine thymoma viral oncogene homolog 2)
    |
    HER-2 overexpression • HER-2 amplification • EGFR overexpression • FGFR1 fusion • PDGFRB overexpression