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BIOMARKER:

PDGFRA expression

i
Other names: Platelet Derived Growth Factor Receptor Alpha, Platelet-Derived Growth Factor Receptor Alpha Polypeptide, Alpha-Type Platelet-Derived Growth Factor Receptor, CD140 Antigen-Like Family Member A, CD140a Antigen, PDGF-R-Alpha, PDGFR-2, PDGFR2, Alpha Platelet-Derived Growth Factor Receptor, Platelet-Derived Growth Factor Alpha Receptor, PDGFR-Alpha, RHEPDGFRA, CD140A
Entrez ID:
6d
Sonic Hedgehog Is an Early Oligodendrocyte Marker During Remyelination. (PubMed, Cells)
We also report a parallel expression of Shh and MBP in oligodendroglial cells during early post-natal myelination of the mouse brain. Thus, we identify a crucial Shh signal involved in oligodendroglial cell differentiation and remyelination, with potential interest in the design of better-targeted remyelinating therapeutic strategies.
Journal
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PDGFRA (Platelet Derived Growth Factor Receptor Alpha) • SHH (Sonic Hedgehog Signaling Molecule)
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FOLR1 expression • PDGFRA expression
8d
Patterns of expression of VEGFR2, PDGFRs and c-Kit in pediatric patients with high grade non-rhabdomyosarcoma soft tissue sarcoma. (PubMed, Front Oncol)
Our findings indicated that tyrosine kinase receptors are upregulated in NRSTS and exhibited a distinct expression pattern within various subgroups. High expression of VEGFR2 and PDGFRα significantly correlated with reduced survival and may guide targeted therapy approaches for this poor prognosis group of patients.
Journal
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KIT (KIT proto-oncogene, receptor tyrosine kinase) • PDGFRA (Platelet Derived Growth Factor Receptor Alpha) • KDR (Kinase insert domain receptor) • PDGFRB (Platelet Derived Growth Factor Receptor Beta)
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KDR overexpression • KDR expression • KIT expression • PDGFRA expression
8ms
Mesenchymal-specific Alms1 knockout in mice recapitulates metabolic features of Alström Syndrome. (PubMed, Mol Metab)
Mesenchymal deletion of Alms1 recapitulates metabolic features of AS, including fatty liver. This confirms a key role for Alms1 in the adipose lineage, where its loss is sufficient to cause systemic metabolic effects and damage to remote organs. Hyperphagia in females may depend on Alms1 deficiency in oligodendrocyte precursor cells rather than neurones. AS should be regarded as a forme fruste of lipodystrophy.
Preclinical • Journal
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PDGFRA (Platelet Derived Growth Factor Receptor Alpha)
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FOLR1 expression • PDGFRA expression
9ms
Lysyl Oxidase Promotes the Formation of Vasculogenic Mimicry in Gastric Cancer through PDGF-PDGFR Pathway. (PubMed, J Cancer)
With inhibition of PDGFRα and PDGFRβ using AG1295 or AG1296, VM formation in gastric cancer cells decreased (P <0.05), but the number of VM structures increased while LOX was added (P < 0.05). LOX partially promotes the formation of VM in gastric cancer through the PDGF-PDGFR signaling pathway.
Journal
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PDGFRA (Platelet Derived Growth Factor Receptor Alpha) • PDGFRB (Platelet Derived Growth Factor Receptor Beta) • CD34 (CD34 molecule) • LOX (Lysyl Oxidase)
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PDGFRA expression
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AG-1296
11ms
Oligodendrocyte progenitor cell-specific delivery of lipid nanoparticles loaded with Olig2 synthetically modified messenger RNA for ischemic stroke therapy. (PubMed, Acta Biomater)
Furthermore, the intravenous administration of C-Olig2 into a murine model of ischemic stroke not only improved blood-brain barrier integrity but also enhanced remyelination and mitigated learning and cognitive deficits. These results underscore the promising therapeutic potential of multifunctional nanomedicine targeting mRNA expression in the context of ischemic stroke.
Journal
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PDGFRA (Platelet Derived Growth Factor Receptor Alpha) • OLIG2 (Oligodendrocyte Transcription Factor 2)
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PDGFRA expression
1year
Astrocyte lipocalin-2 modestly effects disease severity in a mouse model of multiple sclerosis while reducing mature oligodendrocyte protein and mRNA expression. (PubMed, Neurosci Lett)
Immunostaining and qPCR of spinal cord samples showed decreased oligodendrocyte proteolipid protein and transcription factor Olig2 expression, but no changes in PDGFRα expression. These results suggest astrocyte LCN2 contributes to early events in EAE and reduces damage to mature oligodendrocytes at later times.
Preclinical • Journal
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PDGFRA (Platelet Derived Growth Factor Receptor Alpha) • LCN2 (Lipocalin-2) • GFAP (Glial Fibrillary Acidic Protein) • OLIG2 (Oligodendrocyte Transcription Factor 2)
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FOLR1 expression • PDGFRA expression
1year
Stromal heterogeneity may explain increased incidence of metaplastic breast cancer in women of African descent. (PubMed, Nat Commun)
Furthermore, level of phospho-STAT3 is higher in normal and cancerous breast tissues of women of African ancestry. PZP cells transformed with HRas ± SV40-T/t antigens generate metaplastic carcinoma suggesting that these cells are one of the cells-of-origin of metaplastic breast cancers.
Journal • Stroma
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HRAS (Harvey rat sarcoma viral oncogene homolog) • PDGFRA (Platelet Derived Growth Factor Receptor Alpha) • IL6 (Interleukin 6) • ZEB1 (Zinc Finger E-box Binding Homeobox 1) • PROCR (Protein C Receptor)
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PDGFRA expression • ZEB1 expression
over1year
Development of myelin in fetal and postnatal neocortex of the pig, the European wild boar Sus scrofa. (PubMed, Brain Struct Funct)
Indeed, PDGFRα, MBP and MAG expression started earlier in somatosensory than in visual cortex. Taken together, myelination proceeded in white and gray matter and marginal zone of pig cortex before birth with an areal-specific time course, and an almost mature pattern was present at P5 in visual cortex.
Journal
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PDGFRA (Platelet Derived Growth Factor Receptor Alpha)
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PDGFRA expression
almost2years
Sigma-1 Receptor Activation Improves Oligodendrogenesis and Promotes White-Matter Integrity after Stroke in Mice with Diabetic Mellitus. (PubMed, Molecules)
These results indicate that maybe there was more severe white-matter damage in the focal cerebral ischemia of the diabetic mice than in the mice with normal blood glucose levels. Long-term sigma-1 receptor activation may promote oligodendrogenesis and white-matter functional recovery in patients with stroke and with diabetes.
Preclinical • Journal
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PDGFRA (Platelet Derived Growth Factor Receptor Alpha)
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PDGFRA expression
2years
Platelet-derived growth factor signalling pathways in patient-derived glioblastoma cells (EANO 2022)
Despite PDGF receptor expression, the GBM tumour cells, in contrast to pericytes, surprisingly displayed a lack of responses to ligand stimulation through either PDGFRα or PDGFRβ. This warrants further investigation into the signalling mechanisms behind tumour cells to better understand tumour biology.
Clinical
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PDGFRA (Platelet Derived Growth Factor Receptor Alpha) • PDGFRB (Platelet Derived Growth Factor Receptor Beta)
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PDGFRA expression • PDGFRA overexpression
2years
Integrated bioinformatics analysis identifies the effects of Sema3A/NRP1 signaling in oligodendrocytes after spinal cord injury in rats. (PubMed, PeerJ)
Furthermore, inhibition of Sema3A/NRP1 signaling increased the Basso-Beattie-Bresnahan (BBB) score of lower limb motor function in SCI rats and promoted the survival of motor neurons in the ventral horn of the injured spinal cord. Our data suggest that Sema3A/NRP1 signaling may regulate the development of OPCs and OLs after SCI, thereby affecting functional recovery.
Preclinical • Journal
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PDGFRA (Platelet Derived Growth Factor Receptor Alpha) • NRP1 (Neuropilin 1)
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FOLR1 expression • PDGFRA expression
over2years
Absence of Gli1 Decreases PDGFRβ Expression Following Ductal Ligation Injury. (PubMed, FASEB J)
As there was a significant decrease in PDGFRβ area following ligation injury in the absence of Gli1 function, Gli1 signaling may stimulate PDGFRβ expression. Our results suggest that although Gli1 signaling and Gli1 cells do not significantly contribute to injury-induced fibrosis in the salivary gland; PDGFRα and PDGRFβ stromal cells may be potential therapeutic targets.
Journal
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PDGFRA (Platelet Derived Growth Factor Receptor Alpha) • PDGFRB (Platelet Derived Growth Factor Receptor Beta) • GLI1 (GLI Family Zinc Finger 1) • VIM (Vimentin)
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GLI1 expression • VIM expression • PDGFRA expression
over2years
Implantable Bioresponsive Hydrogel Prevents Local Recurrence of Breast Cancer by Enhancing Radiosensitivity. (PubMed, Front Bioeng Biotechnol)
In this study, an implantable drug loading system, sunitinib nanoparticles @ matrix metalloproteinases -response hydrogel (NSMRH), uses enzyme-sensitive hydrogel as a carrier to load sunitinib nanoparticles, was identified...Finally, by studying the molecular mechanism of NSMRH, it was hypothesized that in breast cancer cells, NSMRH cooperated with sensitized radiotherapy, mainly due to significantly blocking the G2/M phase, reducing the DNA repair efficiency, inhibiting tumor angiogenesis, promoting apoptosis, and reversing the abnormal expression of platelet-derived growth factor receptor alpha (PDGFRA) after radiotherapy. These findings suggest that NSMRH's radiation sensitization and anti-tumor activity may aid in the development of a novel method in future clinical applications.
Journal
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PDGFRA (Platelet Derived Growth Factor Receptor Alpha)
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PDGFRA expression
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sunitinib
3years
Sorafenib, Valproic Acid, and Sildenafil in Treating Patients With Recurrent High-Grade Glioma (clinicaltrials.gov)
P2, N=47, Active, not recruiting, Virginia Commonwealth University | Trial completion date: Jun 2022 --> Oct 2027
Clinical • Trial completion date
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PDGFRA (Platelet Derived Growth Factor Receptor Alpha)
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PDGFRA expression
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sorafenib • sildenafil
3years
Postnatal myelination of the immature rat cingulum is regulated by GABAB receptor activity. (PubMed, Dev Neurobiol)
CGP treatment induced a transient maturational delay at P11 and deficits in myelin expression at P15 with increased oligodendroglial proliferation. Our in vivo study indicates GABA receptor activity as a potential modulator of oligodendroglial development.
Preclinical • Journal
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PDGFRA (Platelet Derived Growth Factor Receptor Alpha) • PCNA (Proliferating cell nuclear antigen)
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PDGFRA expression
3years
PDGFRα Enhanced Infection of Breast Cancer Cells with Human Cytomegalovirus but Infection of Fibroblasts Increased Prometastatic Inflammation Involving Lysophosphatidate Signaling. (PubMed, Int J Mol Sci)
We conclude that HCMV infection in tumors will preferentially target tumor-associated fibroblasts and breast cancer cells expressing PDGFRα. HCMV infection in the tumor microenvironment, rather than cancer cells, will increase the inflammatory milieu that could enhance metastasis involving lysophosphatidate.
Journal
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PDGFRA (Platelet Derived Growth Factor Receptor Alpha)
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PDGFRA expression
3years
Generation of Multipotential NG2 Progenitors From Mouse Embryonic Stem Cell-Derived Neural Stem Cells. (PubMed, Front Cell Dev Biol)
Taken together, these data demonstrate that NOP are an intermediate progenitor cell distinguishable from both NSC and primary OPC. Based on this profile, NOP may be useful for modeling mechanisms influencing the earliest stages of oligogenesis, and exploring the cellular and molecular responses of the earliest OL progenitors to conditions that impair myelination in the developing nervous system.
Preclinical • Journal
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PDGFRA (Platelet Derived Growth Factor Receptor Alpha) • CSPG4 (Chondroitin Sulfate Proteoglycan 4) • SOX9 (SRY-Box Transcription Factor 9)
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PDGFRA expression
3years
The HIF1α-PDGFD-PDGFRα axis controls glioblastoma growth at normoxia/mild-hypoxia and confers sensitivity to targeted therapy by echinomycin. (PubMed, J Exp Clin Cancer Res)
HIF1α orchestrates expression of PDGF-D and PDGFRα for constitutive activation of AKT pathway and is crucial for GBM malignancy. Therefore, therapies targeting HIF1α should provide an effective treatment for GBM.
Journal
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PDGFRA (Platelet Derived Growth Factor Receptor Alpha) • HIF1A (Hypoxia inducible factor 1, alpha subunit)
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FOLR1 expression • HIF1A expression • PDGFRA expression
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echinomycin
over3years
Tumor necrosis factor α inhibits the migration of human oligodendrocyte precursor cells in vitro (PubMed, Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi)
OPC migration was reduced significantly in 10 ng/mL TNF-α treated group compared with the blank control. Conclusion TNF-α inhibits the migration of the cultured OPCs.
Preclinical • Journal
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PDGFRA (Platelet Derived Growth Factor Receptor Alpha)
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PDGFRA expression
over3years
Life-long oligodendrocyte development and plasticity. (PubMed, Semin Cell Dev Biol)
Finally, we review recent studies supporting the role of new OL production and "adaptive myelination" in specific behaviours and cognitive processes contributing to learning and long-term memory formation. Our article is not intended to be comprehensive but reflects the authors' past and present interests.
Journal
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PDGFRA (Platelet Derived Growth Factor Receptor Alpha)
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PDGFRA expression
over3years
Single-cell transcriptomic reveals molecular diversity and developmental heterogeneity of human stem cell-derived oligodendrocyte lineage cells. (PubMed, Nat Commun)
Pseudotime trajectory analysis defines developmental pathways of oligodendrocytes vs astrocytes from PDGFRα-expressing hOPCs and predicts differentially expressed genes between the two lineages. In addition, pathway enrichment analysis followed by pharmacological intervention of these pathways confirm that mTOR and cholesterol biosynthesis signaling pathways are involved in maturation of oligodendrocytes from hOPCs.
Journal
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PDGFRA (Platelet Derived Growth Factor Receptor Alpha)
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FOLR1 expression • PDGFRA expression
over3years
Reelin promotes oligodendrocyte precursors migration via the Wnt/β-catenin signaling pathway. (PubMed, Neurol Res)
WIKI4, an inhibitor of Wnt/β-catenin signaling, suppressed the migration of OPCs induced by Reelin. The present study indicated that Reelin promotes OPCs migration via the Wnt/β-catenin pathway.
Journal
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PDGFRA (Platelet Derived Growth Factor Receptor Alpha)
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PDGFRA expression
almost4years
A Study of Carboplatin and Paclitaxel With or Without MEDI-575 in Untreated, Advanced Non-Small Cell Lung Cancer (clinicaltrials.gov)
P1b/2, N=99, Terminated, MedImmune LLC | Phase classification: P1/2 --> P1b/2 | Completed --> Terminated; In conjunction with the overall risk-benefit assessment, study was terminated prematurely due to safety concerns.
Clinical • Phase classification • Trial termination • Combination therapy
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PDGFRA (Platelet Derived Growth Factor Receptor Alpha)
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PDGFRA expression
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carboplatin • paclitaxel • tovetumab (MEDI-575)
4years
Dysregulated PDGFR alpha expression and novel somatic mutations in colorectal cancer: association to RAS wild type status and tumor size. (PubMed, J Transl Med)
Overexpression of PDGFRα in adenocarcinoma suggests its potential role in tumor cells growth and invasion. The association between PDGFRα overexpression in both tumor and stromal adenocarcinoma cells with RAS wild type status suggests its potential role in anti-EGFR therapy resistance and the relevance of using it as specific or adjuvant therapeutic target.
Journal
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PDGFRA (Platelet Derived Growth Factor Receptor Alpha)
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EGFR exon 18 mutation • PDGFRA expression
over4years
Bioinspired Nanofiber Scaffold for Differentiating Bone Marrow-Derived Neural Stem Cells to Oligodendrocyte-Like Cells: Design, Fabrication, and Characterization. (PubMed, Int J Nanomedicine)
Considering surface topography, biocompatibility, electrical conductivity and gene expression, the hybrid PCL/gelatin scaffold with the controlled release of T3 may be considered as a promising candidate to be used as an in vitro model to study patient-derived oligodendrocytes by isolating patient's BMSCs in pathological conditions such as diseases or injuries. Moreover, the resulted oligodendrocytes can be used as a desirable source for transplanting in patients.
Journal
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PDGFRA (Platelet Derived Growth Factor Receptor Alpha) • GFAP (Glial Fibrillary Acidic Protein)
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PDGFRA expression