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PDGFC (Platelet Derived Growth Factor C)

News alerts, weekly reports and conference planners

3ms

NRG1/PDGFC loop between fibroblasts and cancer cells drives paclitaxel resistance via ferroptosis suppression in breast cancer. (PubMed, Cell Death Discov)

In turn, cancer cell-derived PDGFC promotes fibroblast activation and high NRG1 expression, forming a positive feedback loop between NRG1 and PDGFC. This feedback loop ultimately results in a malignant cycle of paclitaxel resistance in BC.

3 months ago

Journal

NRG1 (Neuregulin 1) • PDGFC (Platelet Derived Growth Factor C)

paclitaxel

4ms

Plasma Proteomic Profiling of Colorectal Cancer: Insights from Minimally Invasive Surgical Cohorts. (PubMed, J Proteome Res)

Future investigations of minimally invasive CRC therapies should prioritize cellular proliferation, metabolic reprogramming, stress response, and apoptosis. Collectively, these findings establish a molecular foundation for precision surgery and provide novel insights into the CRC pathophysiology and iatrogenic organ damage mechanisms.

4 months ago

Journal

FOXO1 (Forkhead box O1) • LRP1 (LDL Receptor Related Protein 1) • PDGFC (Platelet Derived Growth Factor C) • TIGAR (TP53 Induced Glycolysis Regulatory Phosphatase)

4ms

Crosstalk between tumor endothelial cells and cancer cells is important for metastasis initiation. (PubMed, Cell Commun Signal)

Our results demonstrate that crosstalk between cancer cells and TEC, partly through angiocrine factors in the TME, induces the rate-limiting steps of metastasis initiation.

4 months ago

Journal

PDGFC (Platelet Derived Growth Factor C)

5ms

PDGFC facilitates enzalutamide resistance in prostate cancer through activation of the Rap1-MAPK pathway. (PubMed, J Cancer Res Clin Oncol)

Our results confirmed the pivotal role of PDGFC in the development of enzalutamide resistance in PCa. Targeting PDGFC or PDGFC mediate Rap1-MAPK pathway may serve as a promising therapeutic strategy for EnzaR PCa.

5 months ago

Journal

AR (Androgen receptor) • PDGFC (Platelet Derived Growth Factor C) • STAT4 (Signal Transducer And Activator Of Transcription 4)

Xtandi (enzalutamide)

8ms

Application and mechanisms of targeting BRD4 in osteosarcoma. (PubMed, Zhong Nan Da Xue Xue Bao Yi Xue Ban)

BRD4 promotes osteosarcoma progression via O-GlcNAc modification at Thr73 and plays a crucial role in tumor growth and metastasis.

8 months ago

Journal

EGFR (Epidermal growth factor receptor) • BRD4 (Bromodomain Containing 4) • PDGFC (Platelet Derived Growth Factor C)

JQ-1

8ms

K88 acetylation of FTO increases its RNA m6A demethylation and promotes tumorigenesis. (PubMed, Oncogene)

K88 acetylation facilitates a reduction in the m6A level of FTO target mRNAs MYC, PDGFC, SOX10, CXCR4, NRF2, PLD1 and CDC42 and subsequently alters the stability or translation of these target mRNAs, thereby promoting tumorigenesis. Hence, K88 acetylation is critical for the RNA m6A demethylase activity and tumor-promoting functions of FTO.

8 months ago

Journal

CXCR4 (Chemokine (C-X-C motif) receptor 4) • SOX10 (SRY-Box 10) • CDC42 (Cell Division Cycle 42) • FTO (Alpha-Ketoglutarate-Dependent Dioxygenase FTO) • PDGFC (Platelet Derived Growth Factor C)

8ms

Melatonin Prevents Tumor Growth: The Role of Genes Controlling the Circadian Clock, the Cell Cycle, and Angiogenesis. (PubMed, J Pineal Res)

These results strengthen the existing hypothesis that circadian disruption contributes to tumor progression and suggest that melatonin exerts anticancer effects by modulating circadian gene expression and angiogenesis. Our findings provide further insight into the mechanism by which melatonin may exert oncostatic effects and highlight its potential as a therapeutic agent in cancers associated with circadian rhythm disruption.

8 months ago

Journal

TNFA (Tumor Necrosis Factor-Alpha) • PER2 (Period Circadian Regulator 2) • PDGFC (Platelet Derived Growth Factor C)

9ms

PDGFC secreted by cancer-associated fibroblasts promotes epithelial-mesenchymal transition and immunosuppression in lung adenocarcinoma. (PubMed, Acta Biochim Biophys Sin (Shanghai))

In particular, PDGFC induces increased PDGFRA expression in both tumor cells and fibroblasts, which can lead to reciprocally positive feedback to accelerate malignant tumor progression. This discovery provides a novel TME-targeted strategy for LUAD treatment.

9 months ago

Journal

PDGFRA (Platelet Derived Growth Factor Receptor Alpha) • MMP2 (Matrix metallopeptidase 2) • PDGFC (Platelet Derived Growth Factor C)

12ms

Cancer-Associated Fibroblasts Genes and Transforming Growth Factor Beta Pathway in Gastric Cancer for Novel Therapeutic Strategy. (PubMed, Cancers (Basel))

A comprehensive understanding of CAFGs and their interaction with the TGFB pathway, including LTBP family genes, may be critical for developing novel therapeutic strategies for GC. Further research is needed to elucidate their functional mechanisms and therapeutic potential.

12 months ago

Journal

TGFB1 (Transforming Growth Factor Beta 1) • COL1A1 (Collagen Type I Alpha 1 Chain) • COL3A1 (Collagen Type III Alpha 1 Chain) • THBS2 (Thrombospondin 2) • PDGFC (Platelet Derived Growth Factor C) • SDC2 (Syndecan 2)

1year

NGF-TrkA Axis Enhances PDGF-C-Mediated Angiogenesis in Osteosarcoma via miR-29b-3p Suppression: A Potential Therapeutic Strategy Using Larotrectinib. (PubMed, Life (Basel))

These findings suggest that the NGF-TrkA axis promotes PDGF-C-mediated angiogenesis by inhibiting miR-29b-3p signaling. Larotrectinib could serve as a potential therapeutic agent targeting NGF-mediated angiogenesis in OS, offering a promising avenue for treatment.

1 year ago

Journal

PDGFC (Platelet Derived Growth Factor C)

Vitrakvi (larotrectinib)

over1year

Roles of PDGF/PDGFR signaling in various organs. (PubMed, Korean J Physiol Pharmacol)

PDGFRα exhibits broader ligand specificity, binding to PDGF-A, PDGF-B, PDGF-C homodimers, and PDGFAB heterodimers, whereas PDGFRβ specifically binds to PDGFB and PDGF-D homodimers. Under both physiological and pathol.

over 1 year ago

Journal

PDGFRA (Platelet Derived Growth Factor Receptor Alpha) • PDGFRB (Platelet Derived Growth Factor Receptor Beta) • PDGFB (Platelet Derived Growth Factor Subunit B) • PDGFC (Platelet Derived Growth Factor C)

over1year

Transcriptome analysis of the cytokine storm-related genes among the subtypes of idiopathic multicentric Castleman disease. (PubMed, J Clin Exp Hematop)

Particularly, upregulated IL33 expression was demonstrated for the first time in iMCD-TAFRO/NOS. Thus, inflammatory signaling, such as JAK-STAT and MAPK, may be enhanced in iMCD-TAFRO/NOS and may be a cytokine storm.

over 1 year ago

Journal

JAK2 (Janus kinase 2) • CXCL10 (Chemokine (C-X-C motif) ligand 10) • JAK1 (Janus Kinase 1) • STAT3 (Signal Transducer And Activator Of Transcription 3) • CXCL9 (Chemokine (C-X-C motif) ligand 9) • CXCL13 (Chemokine (C-X-C motif) ligand 13) • MAPK1 (Mitogen-activated protein kinase 1) • VEGFC (Vascular Endothelial Growth Factor C) • IL17A (Interleukin 17A) • IL17RA (Interleukin 17 Receptor A) • PDGFA (Platelet Derived Growth Factor Subunit A) • PDGFB (Platelet Derived Growth Factor Subunit B) • STAT1 (Signal Transducer And Activator Of Transcription 1) • STAT6 (Signal transducer and activator of transcription 6) • IL18BP (Interleukin 18 Binding Protein) • IL1R1 (Interleukin 1 receptor, type I) • IL1RAP (Interleukin 1 Receptor Accessory Protein) • NFKBIA (NFKB Inhibitor Alpha 2) • STAT2 (Signal transducer and activator of transcription 2) • IL3 (Interleukin 3) • IL33 (Interleukin 33) • MAPK11 (Mitogen-Activated Protein Kinase 11) • MAPK12 (Mitogen-Activated Protein Kinase 12) • MAPK14 (Mitogen-Activated Protein Kinase 14) • MAPK3 (Mitogen-Activated Protein Kinase 3) • MAPK8 (Mitogen-activated protein kinase 8) • MAPK9 (Mitogen-Activated Protein Kinase 9) • PDGFC (Platelet Derived Growth Factor C) • TNFAIP8 (TNF Alpha Induced Protein 8) • MAPK10 (Mitogen-Activated Protein Kinase 10)