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    BIOMARKER:

    PDGFA overexpression

    i
    Other names: PDGFA, Platelet Derived Growth Factor Subunit A, Platelet-Derived Growth Factor Alpha Polypeptide, PDGF1, Platelet-Derived Growth Factor Alpha Chain, Platelet-Derived Growth Factor Subunit A, PDGF Subunit A, PDGF A-Chain, PDGF-A, Platelet-Derived Growth Factor A-Chain, Platelet-Derived Growth Factor A Chain, PDGF-1, PDGFA
    Entrez ID:
    5154
    Related biomarkers:
    Expression
    1year
    KLF5 silencing restrains proliferation, invasion, migration and angiogenesis of gallbladder carcinoma cells by transcriptional regulation of PDGFA. (PubMed, J Cancer Res Clin Oncol)
    Collectively, our results suggest that KLF5 regulates GBC cell proliferation, invasion, migration, angiogenesis, as well as apoptosis, via mediating PDGFA transcriptionally, which might provide a novel therapeutic strategy for treatment of human GBC.
    Journal
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    PDGFA (Platelet Derived Growth Factor Subunit A)
    |
    PDGFA overexpression
    over1year
    Increased Expression of PDGFA Is Associated With Poor Prognosis and Immune Infiltration in Head and Neck Squamous Cell Carcinoma. (PubMed, J Oral Pathol Med)
    Overexpression of PDGFA in HNSC is significantly associated with poor prognosis and immune cell infiltration in the tumor microenvironment (TME). PDGFA has potential as a molecular indicator for diagnosis, prognosis, and immune processes in HNSC.
    Journal
    |
    PDGFA (Platelet Derived Growth Factor Subunit A)
    |
    PDGFA overexpression
    almost3years
    PDGF gene expression and p53 alterations contribute to the biology of diffuse astrocytic gliomas. (PubMed, NPJ Genom Med)
    Conversely, TP53 point mutations were an early and constant feature of mutant LGAs. Our results suggest that members of the PDGF gene family, in concert with different p53 pathway alterations, underlie LGA behaviors.
    Journal
    |
    TP53 (Tumor protein P53) • PDGFA (Platelet Derived Growth Factor Subunit A)
    |
    TP53 mutation • TP53 expression • PDGFA overexpression