^
    Contact us  to learn more about
    our Premium Content:  News alerts, weekly reports and conference planners
    GENE:

    PDE4A (Phosphodiesterase 4A)

    i
    Other names: PDE4A, Phosphodiesterase 4A, DPDE2, CAMP-Specific 3',5'-Cyclic Phosphodiesterase 4A, PDE46, Phosphodiesterase 4A, CAMP-Specific (Dunce (Drosophila)-Homolog Phosphodiesterase E2), Phosphodiesterase E2 Dunce Homolog (Drosophila), Phosphodiesterase E2 Dunce Homolog, Drosophila, Phosphodiesterase 4A, CAMP-Specific (Dunce, Phosphodiesterase 4A, CAMP-Specific, Phosphodiesterase Isozyme , PDE4
    Associations

    News

    Trials
    6ms
    Circ_0049472 downregulation relieves Amyloid-β-induced neuronal injury by modulating PDE4A expression via targeting miR-22-3p in Alzheimer's disease. (PubMed, Metab Brain Dis)
    Mechanistically, circ_0049472 is competitively bound to miR-22-3p to elevate its target PDE4A. Circ_0049472 knockdown alleviated Aβ-induced SK-N-SH and CHP212 cell dysfunctions via targeting the miR-22-3p/PDE4A axis, suggesting that circ_0049472 knockdown might protect from neuronal injury in AD.
    Journal • IO biomarker
    |
    BCL2 (B-cell CLL/lymphoma 2) • IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • CASP3 (Caspase 3) • PCNA (Proliferating cell nuclear antigen) • IL1B (Interleukin 1, beta) • MIR22 (MicroRNA 22) • PDE4A (Phosphodiesterase 4A)
    over1year
    Low PDE4A expression promoted the progression of ovarian cancer by inducing Snail nuclear translocation. (PubMed, Exp Cell Res)
    Notably, Rolipram, the PDE4 inhibitor, mirrored the effects observed with PDE4A deletion. In summary, the downregulation of PDE4A appears to facilitate OC progression by modulating the Snail/EMT pathway, underscoring the potential of PDE4A as a therapeutic target against ovarian cancer metastasis.
    Journal
    |
    PDE4A (Phosphodiesterase 4A)
    almost2years
    Elevated PDE4C level serves as a candidate diagnostic biomarker and correlates with poor survival in thyroid carcinoma. (PubMed, Sci Rep)
    The findings of this study provide a partial basis for the role of PDE4 family in the occurrence and development of THCA. In addition, this study also suggested that PDE4C might be a potential prognostic marker of THCA, which could serve as a reference for future basic and clinical research.
    Journal
    |
    PDE4D (Phosphodiesterase 4D) • PDE4A (Phosphodiesterase 4A)
    over2years
    Resveratrol alleviates amyloid β-induced neuronal apoptosis, inflammation, and oxidative and endoplasmic reticulum stress by circ_0050263/miR-361-3p/PDE4A axis during Alzheimer's disease. (PubMed, Chem Biol Drug Des)
    Moreover, PDE4A upregulation could attenuate Res-mediated neuroprotective effects. In all, Res alleviated Aβ-induced neuronal apoptosis, inflammation, oxidative stress, and ERS via circ_0050263/miR-361-3p/PDE4A axis, providing new insights for AD therapy.
    Journal
    |
    MIR361 (MicroRNA 361) • PDE4A (Phosphodiesterase 4A)
    over2years
    Identification of the shared gene signatures and molecular mechanisms between multiple sclerosis and non-small cell lung cancer. (PubMed, Front Immunol)
    We further observed that PDE4A was closely linked to the sensitivity of several chemotherapy drugs. Given the limitation of studies investigating the molecular mechanisms underlying the correlation between MS and NSCLC, our findings suggest that there are shared pathogenic processes and molecular mechanisms between these two diseases and that PDE4A represents a potential therapeutic target and immune-related biomarker for patients with both MS and NSCLC.
    Journal • Gene Signature
    |
    PDE4A (Phosphodiesterase 4A)