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DRUG CLASS:

PDE4 inhibitor

1d
ALTO-101-201: Study of ALTO-101 in Patients With Schizophrenia (clinicaltrials.gov)
P2, N=82, Recruiting, Alto Neuroscience | Trial completion date: Nov 2025 --> Mar 2026 | Trial primary completion date: Oct 2025 --> Feb 2026
Trial completion date • Trial primary completion date
2d
To Evaluate the Pharmacokinetics of Hemay005 Tablets in Patients With Renal Impairment (clinicaltrials.gov)
P1, N=26, Completed, Ganzhou Hemay Pharmaceutical Co., Ltd | Recruiting --> Completed | Trial completion date: Dec 2025 --> Apr 2025 | Trial primary completion date: Sep 2025 --> Apr 2025
Trial completion • Trial completion date • Trial primary completion date
2d
The Safety and Efficacy of Roflumilast Foam in HS (clinicaltrials.gov)
P2, N=20, Not yet recruiting, Beth Israel Deaconess Medical Center
New P2 trial
3d
Efficacy and Safety of add-on Apremilast Versus add-on Methotrexate in Patients With Oral Lichen Planus (clinicaltrials.gov)
P4, N=64, Completed, All India Institute of Medical Sciences, Bhubaneswar | Recruiting --> Completed
Trial completion
3d
Pharmacokinetic Interactions Between Hemay005 Tablets and Midazolam Maleate Tablets (clinicaltrials.gov)
P1, N=20, Completed, Ganzhou Hemay Pharmaceutical Co., Ltd | Recruiting --> Completed | Trial completion date: May 2025 --> Jan 2025
Trial completion • Trial completion date
8d
A Phase II Clinical Trial on the Efficacy and Safety of TQC3721 Inhalation Powder (clinicaltrials.gov)
P2, N=195, Not yet recruiting, Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
New P2 trial
10d
Trial completion
18d
Efficacy and Safety of Roflumilast versus Alpha-Lipoic Acid in Type 2 Diabetes with Neuropathy: A Comparative Clinical Study. (PubMed, Diabetes Metab Syndr Obes)
Roflumilast may offer superior glycemic and oxidative stress control benefits, though neuropathy symptoms control was comparable to ALA. (NCT05369793).
Journal
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TNFA (Tumor Necrosis Factor-Alpha)
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Daliresp (roflumilast)
19d
A Study of Apremilast in Pediatric Participants in Children With Mild to Moderate Plaque Psoriasis (clinicaltrials.gov)
P3, N=51, Active, not recruiting, Amgen | Recruiting --> Active, not recruiting
Enrollment closed
2ms
A 52-week, Placebo- and Active- Controlled (Roflumilast, Daliresp® 500µg) Study to Evaluate the Efficacy and Safety of Two Doses of CHF6001 DPI (Tanimilast) as add-on to Maintenance Triple Therapy in Subjects With COPD and Chronic Bronchitis. (PILLAR) (clinicaltrials.gov)
P3, N=3973, Active, not recruiting, Chiesi Farmaceutici S.p.A. | Recruiting --> Active, not recruiting | Trial completion date: Apr 2027 --> Dec 2025 | Trial primary completion date: Apr 2027 --> Dec 2025
Enrollment closed • Trial completion date • Trial primary completion date
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Daliresp (roflumilast)