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DRUG CLASS:

PDE4 inhibitor

3d
Efficacy and Safety of Roflumilast Cream in Subjects with Atopic Dermatitis (clinicaltrials.gov)
P3, N=351, Recruiting, Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd. | Not yet recruiting --> Recruiting | N=210 --> 351
Enrollment open • Enrollment change
5d
Trial completion
7d
A Study of Apremilast in Children With Oral Ulcers Associated With Behçet's Disease or Juvenile Psoriatic Arthritis (clinicaltrials.gov)
P3, N=48, Recruiting, Amgen | Trial completion date: Dec 2032 --> Mar 2036 | Trial primary completion date: Dec 2032 --> Mar 2036
Trial completion date • Trial primary completion date
9d
A Supramolecular Deferoxamine-Crisaborole Nanoparticle Targets Ferroptosis, Inflammation, and Oxidative Stress in the Treatment of Retinal Ischemia/Reperfusion Injury. (PubMed, Nano Lett)
Electroretinogram and histochemical analysis confirm the nanoparticles' superior protective effects compared to control treatments. This study proposes a novel nanoparticle approach for retinal IR injury by simultaneously targeting multiple pathogenic pathways.
Journal
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IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • HMOX1 (Heme Oxygenase 1) • GPX4 (Glutathione Peroxidase 4) • ACSL4 (Acyl-CoA Synthetase Long Chain Family Member 4) • IL1B (Interleukin 1, beta)
9d
PEAPOD: Apremilast Pediatric Study in Children With Active Juvenile Psoriatic Arthritis (clinicaltrials.gov)
P3, N=60, Recruiting, Amgen | Trial completion date: Dec 2028 --> Jul 2031 | Trial primary completion date: Mar 2028 --> Oct 2030
Trial completion date • Trial primary completion date
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CRP (C-reactive protein)
10d
HDM3014-301: Efficacy and Safety of Roflumilast Cream 0.3% in Subjects with Plaque Psoriasis: a Phase 3 Study (clinicaltrials.gov)
P3, N=189, Recruiting, Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd. | Not yet recruiting --> Recruiting
Enrollment open
14d
Roflumilast in Non-CF Bronchiectasis Study (2019) (clinicaltrials.gov)
P2, N=42, Completed, The University of Hong Kong | Recruiting --> Completed | N=27 --> 42
Trial completion • Enrollment change
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Daliresp (roflumilast)
17d
RECLAIM: Recovering From COVID-19 Lingering Symptoms Adaptive Integrative Medicine (clinicaltrials.gov)
P2/3, N=1000, Recruiting, University Health Network, Toronto | Trial completion date: Dec 2025 --> Dec 2026 | Trial primary completion date: May 2025 --> May 2026
Trial completion date • Trial primary completion date
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Eyevinal (ibudilast)
1m
A Study in Healthy People to Compare 2 Different Formulations of Nerandomilast Tablets When Taken With or Without Food (clinicaltrials.gov)
P1, N=15, Active, not recruiting, Boehringer Ingelheim | Recruiting --> Active, not recruiting
Enrollment closed
1m
MN-001 in Non-alcoholic Fatty Liver Disease, Type 2 Diabetes Mellitus, and Hypertriglyceridemia (clinicaltrials.gov)
P2, N=40, Recruiting, MediciNova | Trial completion date: Dec 2024 --> Dec 2026 | Trial primary completion date: Jun 2024 --> Dec 2025
Trial completion date • Trial primary completion date
1m
The holistic management of peripheral spondyloarthritis: focus on articular involvement in patients with inflammatory bowel disease. (PubMed, Reumatismo)
Early identification of pSpA is crucial in IBD patients to enable timely intervention, prevent structural damage, and minimize disability. A multidisciplinary, holistic approach addressing musculoskeletal and extra-musculoskeletal manifestations is key to optimal patient outcomes.
Journal
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IL23A (Interleukin 23 Subunit Alpha)
1m
Roflumilast and TMS Motor Plasticity (clinicaltrials.gov)
P1, N=20, Recruiting, University of Calgary | Not yet recruiting --> Recruiting | Initiation date: Aug 2024 --> Nov 2024
Enrollment open • Trial initiation date
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Daliresp (roflumilast)
1m
Phase classification
2ms
New P2 trial
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Daliresp (roflumilast)
2ms
New P1 trial
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CRP (C-reactive protein)
2ms
RPL554-CO-303: Effect of Ensifentrine Treatment on CAT Score (clinicaltrials.gov)
P3, N=20, Active, not recruiting, Verona Pharma plc | Recruiting --> Active, not recruiting
Enrollment closed
2ms
EBULO: A 20-Week Study Assessing the Efficacy of Apremilast in Patients With EB Simplex Generalized (clinicaltrials.gov)
P2, N=20, Recruiting, Centre Hospitalier Universitaire de Nice | Not yet recruiting --> Recruiting | Trial completion date: Aug 2025 --> Dec 2025
Enrollment open • Trial completion date
2ms
EBULO: A 20-Week Study Assessing the Efficacy of Apremilast in Patients With EB Simplex Generalized (clinicaltrials.gov)
P2, N=20, Not yet recruiting, Centre Hospitalier Universitaire de Nice | Trial completion date: Aug 2024 --> Aug 2025 | Initiation date: Aug 2024 --> Nov 2024 | Trial primary completion date: Aug 2024 --> Aug 2025
Trial completion date • Trial initiation date • Trial primary completion date
2ms
Efficacy and Safety of Roflumilast Cream 0.3% in Subjects with Plaque Psoriasis: a Phase 3 Study (clinicaltrials.gov)
P3, N=189, Not yet recruiting, Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd.
New P3 trial
2ms
New P1 trial
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Daliresp (roflumilast)
2ms
Enrollment open
3ms
Efficacy and Safety of Roflumilast Cream in Subjects with Atopic Dermatitis: a Phase 3 Study (clinicaltrials.gov)
P3, N=210, Not yet recruiting, Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd.
New P3 trial
3ms
New P1 trial
3ms
Bioequivalence Test of Hemay005 Tablets (clinicaltrials.gov)
P1, N=28, Not yet recruiting, Ganzhou Hemay Pharmaceutical Co., Ltd
New P1 trial
3ms
TQC3721-II-03: A Clinical Trial of TQC3721 Suspension for Inhalation in Patients With Moderate to Severe Chronic Obstructive Pulmonary Disease (clinicaltrials.gov)
P2, N=240, Recruiting, Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Not yet recruiting --> Recruiting
Enrollment open
3ms
Cyclic adenosine monophosphate critically modulates cardiac GLP-1 receptor's anti-inflammatory effects. (PubMed, Inflamm Res)
cAMP, via activation of both PKA and Epac, is essential for GLP1R`s anti-inflammatory signaling in cardiac cells and that cAMP levels crucially regulate the anti-inflammatory efficacy of GLP1R agonists in the heart. Strategies that elevate cardiac cAMP levels, such as PDE4 inhibition, may potentiate the cardiovascular, including anti-inflammatory, benefits of GLP1R agonist drugs.
Journal
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IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • MMP9 (Matrix metallopeptidase 9)
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IL6 expression
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Daliresp (roflumilast)
3ms
New P4 trial • Combination therapy
3ms
A Phase II Study of Ensifentrine in Non-Cystic Fibrosis Bronchiectasis (clinicaltrials.gov)
P2, N=180, Recruiting, Verona Pharma plc | Not yet recruiting --> Recruiting
Enrollment open
3ms
Trial completion
3ms
Trial completion
3ms
Tuberculosis reactivation following apremilast therapy for psoriasis: Time to consider routine TB screening? (PubMed, Australas J Dermatol)
We describe a case of M.tuberculosis reactivation shortly after commencement of apremilast for psoriasis. We are recommending clinicians perform LTBI risk assessment in all patients, and appropriate LTBI screening in select populations prior to apremilast initiation.
Journal
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TNFA (Tumor Necrosis Factor-Alpha)
4ms
HPP737 Substance Balance Study in Human (clinicaltrials.gov)
P=N/A, N=8, Not yet recruiting, Newsoara Biopharma Co., Ltd.
New trial
4ms
Crisaborole combined with vitamin D demonstrates superior therapeutic efficacy over either monotherapy in mice with allergic contact dermatitis. (PubMed, Sci Rep)
The combination of vitamin D and crisaborole significantly reduces inflammation and epidermal hyperkeratosis in a mouse model of allergic contact dermatitis, demonstrating superior therapeutic efficacy compared to either treatment alone. This suggests that the combined therapy could be a promising approach for the prevention and treatment of allergic contact dermatitis.
Preclinical • Journal
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IFNG (Interferon, gamma) • IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • CCL2 (Chemokine (C-C motif) ligand 2) • IL17A (Interleukin 17A) • CCR2 (C-C Motif Chemokine Receptor 2) • IL4 (Interleukin 4)
4ms
Eucrisa for Atopic Dermatitis (clinicaltrials.gov)
P1, N=28, Active, not recruiting, Wake Forest University Health Sciences | Trial completion date: Dec 2024 --> Jul 2025 | Trial primary completion date: Aug 2024 --> Jan 2025
Trial completion date • Trial primary completion date • Adherence
4ms
MN-166-GBM-1201: Study to Evaluate Ibudilast and TMZ Combo Treatment in Newly Diagnosed and Recurrent Glioblastoma (clinicaltrials.gov)
P1/2, N=50, Active, not recruiting, MediciNova | Trial completion date: Jun 2024 --> Dec 2024
Trial completion date
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temozolomide • Eyevinal (ibudilast)
4ms
Efficacy, Safety, Tolerability, and Biomarkers of MN-166 (Ibudilast) in Patients Hospitalized With COVID-19 and at Risk for ARDS (clinicaltrials.gov)
P2, N=36, Completed, MediciNova | Active, not recruiting --> Completed | Trial completion date: Dec 2023 --> Aug 2024
Trial completion • Trial completion date
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Eyevinal (ibudilast)