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    BIOMARKER:

    PD-L1 overexpression + ER positive

    i
    Other names: PD-L1, CD274, HPD-L1, PD-L1, B7H1, PDL1, Programmed death ligand 1, B7-H1, B7-H, PDCD1L1, PDCD1LG1, PDCD1 Ligand 1, B7 homolog 1, CD274 Antigen, Programmed cell death 1 ligand 1, CD274 molecule, ESR1, Era, ESR, NR3A1, ER, ER beta
    Entrez ID:
    29126; 2099
    Related biomarkers:
    Expression
    Mutation
    CNA
    Fusion
    Others
    6ms
    Biomarker Results in High-risk Estrogen Receptor Positive, Human Epidermal Growth Factor Receptor 2 Negative Primary Breast Cancer Following Neoadjuvant Chemotherapy ± Nivolumab: an Exploratory Analysis of CheckMate 7FL (SABCS 2023)
    Greater PD-L1 expression was associated with higher pCR and RCB 0–1 rates, suggesting that pts with PD-L1+, high-risk, ER+/HER2− primary BC can achieve substantial pCR rates with the addition of NIVO to NACT. Table. Summary pCR and RCB 0–1 rates by PD-L1 SP142 and 28-8 CPS at various cutoffs.
    Clinical • PD(L)-1 Biomarker • IO biomarker
    |
    HER-2 (Human epidermal growth factor receptor 2) • PD-L1 (Programmed death ligand 1) • ER (Estrogen receptor) • PGR (Progesterone receptor)
    |
    PD-L1 expression • ER positive • HER-2 negative • EGFR positive • PGR expression • PD-L1 overexpression + ER positive
    |
    VENTANA PD-L1 (SP142) Assay • PD-L1 IHC 28-8 pharmDx
    |
    Opdivo (nivolumab)