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    BIOMARKER:

    PD-L1 expression + PVR expression

    i
    Other names: PD-L1, CD274, HPD-L1, PD-L1, B7H1, PDL1, Programmed death ligand 1, B7-H1, B7-H, PDCD1L1, PDCD1LG1, PDCD1 Ligand 1, B7 homolog 1, CD274 Antigen, Programmed cell death 1 ligand 1, CD274 molecule, PVR, PVR Cell Adhesion Molecule, Poliovirus Receptor, Necl-5, CD155, NECL5, HVED, PVS, Nectin-Like Protein 5, Tage4, Nectin-Like 5, CD155 Antigen, NECL-5, TAGE4
    Entrez ID:
    29126; 5817
    Related biomarkers:
    Expression
    Mutation
    CNA
    Others
    over1year
    The role of myeloid cell-expressed PVRL2 in high-grade serous ovarian cancer (AACR 2023)
    PVRL2 deficiency selectively in hematopoietically-reconstituted immune cells (primarily myeloid cells) and not in tumor cells conferred a significant survival benefit in our syngeneic OC model. Taken together, blockade of the PVRL2-PVRIG axis in conjunction with PD-1/L1 inhibition may be an effective modality in OC.
    PD(L)-1 Biomarker • IO biomarker
    |
    CD8 (cluster of differentiation 8) • CD68 (CD68 Molecule) • PVR (PVR Cell Adhesion Molecule)
    |
    PD-L1 expression • PD-L1 expression + PVR expression • CD68 positive