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DRUG CLASS:

PCSK9 inhibitor

5d
New P2/3 trial
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APOB (Apolipoprotein B)
6d
Integrative Proteomic and Lipidomic Analysis of Post-Myocardial Infarction Patients Treated With PCSK9 Antibodies and Statins. (PubMed, Circ Genom Precis Med)
Combined proteomics and lipidomics analyses was conducted on plasma from 265 patients with acute MI from the PACMAN-AMI (Effects of the PCSK9 Antibody Alirocumab on Coronary Atherosclerosis in Patients With Acute Myocardial Infarction) randomized, placebo-controlled PCSK9 mAb trial and 34 patients without MI with hyperlipidemia from the Vienna Lipid Clinic registry, also receiving PCSK9 mAbs...Combining PCSK9 mAbs with high-intensity statins mitigates post-MI increases in lipoprotein(a). URL: https://www.clinicaltrials.gov; Unique identifier: NCT03067844.
Journal
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APOB (Apolipoprotein B) • APOE (Apolipoprotein E)
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Praluent (alirocumab)
10d
New trial
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Repatha (evolocumab)
14d
EVEREST: Evolocumab in Patients With Multivessel Coronary Disease After Acute Myocardial Infarction: A Target Trial Emulation (clinicaltrials.gov)
P=N/A, N=1862, Completed, Shanghai Zhongshan Hospital | Active, not recruiting --> Completed | N=912 --> 1862
Trial completion • Enrollment change
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Repatha (evolocumab)
16d
A Randomized, Open-Label, Blinded Endpoint Evaluation Study of Early Evolocumab Administration in Patients with Atherosclerotic Acute Ischemic Stroke Following Successful Thrombectomy. (ChiCTR2600117460)
P=N/A, N=60, Recruiting, The Affiliated Hospital of Xuzhou Medical University; The Affiliated Hospital of Xuzhou Medical University, Xuzhou City, Jiangsu Province
New trial
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Repatha (evolocumab)
16d
A phase IIa, randomized, open-label, blinded endpoint evaluation study of early administration of evolocumab after thrombolysis in patients with atherosclerotic acute ischemic stroke (ChiCTR2500115300)
P=N/A, N=132, Recruiting, The Affiliated Hospital of Xuzhou Medical University; The Affiliated Hospital of Xuzhou Medical University, Xuzhou City, Jiangsu Province
New trial
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Repatha (evolocumab) • atorvastatin
16d
A Trial of a PCSK9 Inhibitor in Advanced Breast Cancer (ChiCTR2500115123)
P=N/A, N=60, Not yet recruiting, The First Affiliated Hospital of Xi'an Jiaotong University; The First Affiliated Hospital of Xi'an Jiaotong University
New trial
16d
New trial
16d
A Clinical Exploratory Study of YOLT-101 in the Treatment of Heterozygous Familial Hypercholesterolemia (HeFH) or Atherosclerotic Cardiovascular Disease (ASCVD) (ChiCTR2500112984)
P=N/A, N=30, Not yet recruiting, Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine; Renji Hospital Affiliated to Shanghai Jiao Tong University School of Me
New trial
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PCSK9 (Proprotein Convertase Subtilisin/Kexin Type 9) • APOB (Apolipoprotein B)
16d
The Effect of PCSK9 Inhibitors on Reducing Cardiovascular and Cerebrovascular Plaque Burden in Patients with Acute Coronary Syndrome (ChiCTR2500112472)
P=N/A, N=268, Not yet recruiting, The Sixth Medical Center of PLA General Hospital; The Sixth Medical Center of PLA General Hospital
New trial
16d
Clinical Efficacy of Inclisiran in Preventing Postoperative Complications in Patients Undergoing Coronary Artery Bypass Grafting (ChiCTR2500114213)
P4, N=100, Not yet recruiting, The First Affiliated Hospital of Nanjing Medical University; The First Affiliated Hospital of Nanjing Medical University
New P4 trial