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    GENE:

    PCDHA1 (Protocadherin Alpha 1)

    i
    Other names: Protocadherin Alpha 1, Protocadherin Alpha-1, PCDH-Alpha-1, PCDH-ALPHA1, PCDHA1
    3ms
    DNA Methylation Levels at the C3orf37 Loci Correlate With Prostate Cancer Grade. (PubMed, Int J Urol)
    Quantitative analysis of DNA methylation at CpG sites near the C3orf37 gene appears to be a promising approach to distinguish between index and indolent prostate cancer cells.
    Journal
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    BCAT1 (Branched Chain Amino Acid Transaminase 1 ) • PCDHA1 (Protocadherin Alpha 1)
    8ms
    cfMethylPre: deep transfer learning enhances cancer detection based on circulating cell-free DNA methylation profiling. (PubMed, Brief Bioinform)
    Through model interpretation and biological experimental validation, we identified three novel breast cancer genes-PCDHA10, PRICKLE2, and PRTG-demonstrating their inhibitory effects on cell proliferation and migration in breast cancer cell lines. These findings establish cfMethylPre as a powerful and interpretable tool for cancer diagnostics and biological discovery, paving the way for its application in precision oncology.
    Journal
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    PCDHA1 (Protocadherin Alpha 1)
    over1year
    Dual-modified antisense oligonucleotides targeting oncogenic protocadherin to treat gastric cancer. (PubMed, Br J Cancer)
    AmNA-modified anti-PCDHA11 ASOs offer a promising therapeutic strategy for the treatment of gastric cancer and other solid malignancies.
    Journal
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    GNA11 (G Protein Subunit Alpha 11) • PCDHA1 (Protocadherin Alpha 1) • CDH23 (Cadherin Related 23)
    almost2years
    miR-185-5p May Modulate the Chemosensitivity of LUSC to Cisplatin via Targeting PCDHA11: Multi-omics Analysis and Experimental Validation. (PubMed, Biochem Genet)
    Furthermore, the proliferation of silencing PCDHA11 was significantly slower than that of overexpression of PCDHA11, which means PCDHA11 overexpression weakened the anticancer effects of cisplatin, and silencing PCDHA11 enhanced the effects. This study demonstrated that miR-185-5p was involved in chemoresistance of LUSC cells to cisplatin partly via down-regulating PCDHA11, which may promote understanding the underlying molecular mechanisms of drug response.
    Journal
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    PCDHA1 (Protocadherin Alpha 1) • miR-185 (MicroRNA 185)
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    miR-185 expression
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    cisplatin
    2years
    A recurrence-predictive model based on eight genes and tumor mutational burden/microsatellite instability status in Stage II/III colorectal cancer. (PubMed, Cancer Med)
    In conclusion, the G8plus score is a powerful biomarker for predicting the risk of recurrence in patients with stage II/III CRC. It can be used to stratify patients who benefit from ACT and immunotherapy.
    Journal • Tumor mutational burden • Microsatellite instability • IO biomarker • Predictive model
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    TMB (Tumor Mutational Burden) • MSI (Microsatellite instability) • PCDHA1 (Protocadherin Alpha 1) • SMARCA2 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily A, Member 2) • CUL9 (Cullin 9)
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    TLS gene signature
    2years
    Establishment of a 6-signature risk model associated with cellular senescence for predicting the prognosis of breast cancer. (PubMed, Medicine (Baltimore))
    Glycometabolism pathways were further found to negatively correlate with the infiltration level of CD8 T-cells and natural killer cells but positively correlate with M2 macrophage infiltration and expressions of tissue degeneration biomarkers, which suggested the deficit immune surveillance and risk of tumor migration. The constructed 6-gene model based on cellular senescence could be an effective indicator for predicting the prognosis of BRCA.
    Journal • BRCA Biomarker
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    CD8 (cluster of differentiation 8) • PCDHA1 (Protocadherin Alpha 1) • PGK1 (Phosphoglycerate Kinase 1)
    over2years
    PCDHA1 High Expression is Associated With Poor Prognosis and Correlated With Immune Cell Infiltration in Breast Cancer. (PubMed, Clin Breast Cancer)
    This study demonstrated that PCDHA1 effectively predicted BC prognosis. Upregulated PCDHA1 activated metabolism pathways, and promoted NK cells and chemokines. PCDHA1 overexpression enhanced BC cell proliferation and invasion. Therefore, an understanding of PCDHA1's function in BC may yield insights into the mechanisms of BC development.
    Journal • BRCA Biomarker • Immune cell
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    BRCA (Breast cancer early onset) • PCDHA1 (Protocadherin Alpha 1) • CDH23 (Cadherin Related 23)
    almost3years
    Multiregional Sequencing Analysis Reveals Extensive Genetic Heterogeneity in Gastric Tumors from Latinos. (PubMed, Cancer Res Commun)
    Our findings of a higher frequency of a poor prognosis associated molecular subtype in Latinos and a possible new aflatoxin gastric cancer etiology also advance cancer disparities research. Our study contributes to advancing our knowledge of gastric carcinogenesis, diagnostics, and cancer health disparities.
    Journal
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    RAD50 (RAD50 Double Strand Break Repair Protein) • FAT4 (FAT Atypical Cadherin 4) • FSIP2 (Fibrous Sheath Interacting Protein 2) • PCDHA1 (Protocadherin Alpha 1) • RECQL4( RecQ Like Helicase 4)
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    RAD50 mutation • RECQL4 mutation
    4years
    Genomic Landscape of TCR Alpha-Beta and TCR Gamma-Delta T-Large Granular Lymphocyte Leukemia. (PubMed, Blood)
    Finally, gene expression analysis revealed enrichment of interferon gamma signaling and decreased PI3K-Akt signaling for STAT3 mutant patients. These findings highlight the clinical and molecular heterogeneity of this rare disorder.
    Journal • Tumor Mutational Burden
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    TMB (Tumor Mutational Burden) • DNMT3A (DNA methyltransferase 1) • TET2 (Tet Methylcytosine Dioxygenase 2) • IFNG (Interferon, gamma) • KMT2D (Lysine Methyltransferase 2D) • STAT3 (Signal Transducer And Activator Of Transcription 3) • KDM6A (Lysine Demethylase 6A) • PIK3R1 (Phosphoinositide-3-Kinase Regulatory Subunit 1) • TNFAIP3 (TNF Alpha Induced Protein 3) • STAT5B (Signal Transducer And Activator Of Transcription 5B) • PCDHA1 (Protocadherin Alpha 1)
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    KMT2D mutation • STAT3 mutation • PIK3R1 mutation
    over4years
    Identification and Prognostic Value Exploration of Cyclophosphamide (Cytoxan)-Centered Chemotherapy Response-Associated Genes in Breast Cancer. (PubMed, DNA Cell Biol)
    Furthermore, the nomogram model showed that the predicted survival probability is closely related to the actual survival probability. In conclusion, we identified 159 genes potentially correlated with the Cytoxan response of BRCA patients, which had prognostic value in BRCA.
    Journal • BRCA Biomarker
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    BRCA (Breast cancer early onset) • PCDHA1 (Protocadherin Alpha 1)
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    cyclophosphamide intravenous
    over4years
    Immunogenomic profiling and pathological response results from a clinical trial of docetaxel and carboplatin in triple-negative breast cancer. (PubMed, Breast Cancer Res Treat)
    Neoadjuvant docetaxel and carboplatin resulted in a pCR of 45.7%. WES and immune profiling differentiated patients with and without pCR.
    Clinical • Journal • Tumor Mutational Burden • PD(L)-1 Biomarker • IO biomarker
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    EGFR (Epidermal growth factor receptor) • PD-L1 (Programmed death ligand 1) • TP53 (Tumor protein P53) • TMB (Tumor Mutational Burden) • RB1 (RB Transcriptional Corepressor 1) • CD8 (cluster of differentiation 8) • IFNG (Interferon, gamma) • CTLA4 (Cytotoxic T-Lymphocyte Associated Protein 4) • PD-L2 (Programmed Cell Death 1 Ligand 2) • RAD51 (RAD51 Homolog A) • IDO1 (Indoleamine 2,3-dioxygenase 1) • COL4A5 (Collagen Type IV Alpha 5 Chain) • CACNA1S (Calcium Voltage-Gated Channel Subunit Alpha1 S) • CFAP58 (Cilia And Flagella Associated Protein 58) • COL22A1 (Collagen Type XXII Alpha 1 Chain) • KPRP (Keratinocyte Proline Rich Protein) • L1CAM (L1 cell adhesion molecule) • PCDHA1 (Protocadherin Alpha 1) • SDK2 (Sidekick Cell Adhesion Molecule 2)
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    EGFR mutation • TMB-H • COL4A5 mutation • PCDHA1 mutation • RAD51 mutation
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    carboplatin • docetaxel