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    GENE:

    PCAT6 (Prostate Cancer Associated Transcript 6)

    i
    Other names: PCAT6, Prostate Cancer Associated Transcript 6, Onco-LncRNA-96, NcRNA-A2, KDM5BAS1, PCAN-R1, Prostate Cancer Associated Transcript 6 (Non-Protein Coding), Prostate Cancer-Associated Noncoding RNA 1, KDM5B Antisense RNA 1 (Head To Head), KDM5B-AS1, KDM5B Antisense RNA 1 (Non-Protein Coding, Noncoding RNA-Activating 2, NONHSAG003976.2, HSALNG0009743, HSALNG0009747, PCAT6
    Associations

    News

    Trials
    12ms
    Evolutionary learning-derived lncRNA signature with biomarker discovery for predicting stage of colon adenocarcinoma. (PubMed, Annu Int Conf IEEE Eng Med Biol Soc)
    Furthermore, the lncRNAs of the signature were prioritized, with the top five being TMEM105, DUXAP8, APCDD1L-DT, PCAT6, and a novel transcript, ENSG00000226308. Furthermore, both Kyoto Encyclopedia of Genes and Genomes pathway and Disease Ontology analyses provided strong support for the viability of this model-independent signature, emphasising ENSG00000226308 as a promising biomarker.
    Journal
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    APCDD1L-DT (APCDD1L Divergent Transcript) • DUXAP8 (Double Homeobox A Pseudogene 8) • PCAT6 (Prostate Cancer Associated Transcript 6)
    1year
    LncRNA PCAT6 promotes progression and metastasis of colonic neuroendocrine carcinoma via MAPK pathway. (PubMed, World J Gastrointest Oncol)
    In conclusion, lncRNA PCAT6 accelerates the process of colonic NEC by activating ERK/p38 MAPK signaling through targeting miR-326. These results might provide useful information for exploring the potential therapeutic targets in colonic NEC.
    Journal
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    NCAM1 (Neural cell adhesion molecule 1) • MIR326 (MicroRNA 326) • PCAT6 (Prostate Cancer Associated Transcript 6)
    1year
    Constructing methylation-driven ceRNA networks unveil tumor heterogeneity and predict patient prognosis. (PubMed, Hum Mol Genet)
    Our findings also demonstrate the prognostic potential of cancer-specific ceRNA relationships, highlighting their relevance in predicting patient survival outcomes. This integrated transcriptomic and epigenomic analysis provides new insights into cancer biology and regulatory mechanisms.
    Journal
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    PVT1 (Pvt1 Oncogene) • PCAT6 (Prostate Cancer Associated Transcript 6) • CASC2 (Cancer Susceptibility 2)
    over1year
    LncRNA PCAT6 promotes the occurrence of laryngeal squamous cell carcinoma via modulation of the miR-4731-5p/NOTCH3 axis. (PubMed, J Radiat Res)
    Furthermore, lncRNA PCAT6 modulated notch receptor 3 expression and activated NOTCH signaling pathway via serving as a sponge for miR-4731-5p. Taken together, lncRNA PCAT6 was identified as an oncogene in LSCC, which revealed that PCAT6 might be used as potential therapeutic target for LSCC.
    Journal
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    NOTCH3 (Notch Receptor 3) • MIR4731 (MicroRNA 4731) • PCAT6 (Prostate Cancer Associated Transcript 6)
    over1year
    Exploring the potential biological significance of KDELR family genes in lung adenocarcinoma. (PubMed, Sci Rep)
    Our multiple analyses suggested that the KDELRs are important signaling molecules in LUAD. These results provided novel insights for developing prognostic markers and novel therapies of LUAD.
    Journal • IO biomarker
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    CD8 (cluster of differentiation 8) • CTLA4 (Cytotoxic T-Lymphocyte Associated Protein 4) • KDELR3 (KDEL Endoplasmic Reticulum Protein Retention Receptor 3) • EP300 (E1A binding protein p300) • SPI1 (Spi-1 Proto-Oncogene) • MIR326 (MicroRNA 326) • PCAT6 (Prostate Cancer Associated Transcript 6)
    almost2years
    HnRNPA2B1 ISGylation Regulates m6A-Tagged mRNA Selective Export via ALYREF/NXF1 Complex to Foster Breast Cancer Development. (PubMed, Adv Sci (Weinh))
    HnRNPA2B1 knockdown or mRNA export inhibition can result in the retention of nuclear m6A-tagged mRNA associated with stemness maintenance, which suppresses BCSCs self-renewal and effectively improves the efficacy of doxorubicin therapy. These findings demonstrate the pivotal role of m6A-modified mRNA nuclear export in BC progression, highlighting that the inhibition of m6A-tagged mRNA and its nuclear export is a potential therapeutic strategy for the amelioration of cancer chemotherapy.
    Journal
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    NXF1 (Nuclear RNA Export Factor 1) • ALYREF (Aly/REF Export Factor) • HNRNPA2B1 (Heterogeneous Nuclear Ribonucleoprotein A2/B1) • PCAT6 (Prostate Cancer Associated Transcript 6)
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    doxorubicin hydrochloride
    almost2years
    Prostate cancer-associated transcript 6 (PCAT6) promotes epithelial-mesenchymal transition and stemness and worsens prognosis in patients with colorectal cancer. (PubMed, Acta Biochim Biophys Sin (Shanghai))
    Knockdown of PCAT6 is observed to impede the metastatic phenotype of CRC, as evidenced by functional assays, demonstrating the suppression of epithelial-mesenchymal transition (EMT) and stemness. Our findings show the significance of PCAT6 in mCRC and its potential use as a prognostic biomarker.
    Journal
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    PCAT6 (Prostate Cancer Associated Transcript 6)
    almost2years
    LncRNA PCAT6 mediates UBFD1 expression via sponging miR-545-3p in breast cancer cells. (PubMed, Noncoding RNA Res)
    Our study provided evidence that PCAT6 activates UBFD1 expression via sponging miR-545-3p to increase carcinogenesis of breast cancer cells. Based on the nature of UBFD1 as a polyubiquitin binding protein, our study suggested that ubiquitin pathway might contribute to breast cancer progression.
    Journal
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    MIR545 (MicroRNA 545) • PCAT6 (Prostate Cancer Associated Transcript 6)
    almost2years
    LncRNA PCAT6 is a predictor of poor prognosis of colorectal cancer. (PubMed, J Gastrointest Oncol)
    The high expression of lncRNA PCAT6 in CRC cell lines was demonstrated by PCR experiments. PCAT6 represents a promising prognostic biomarker of poor CRC patient survival outcomes, with DNA methylation and RNA-mediated gene silencing being potentially promising mechanistic pathways whereby this lncRNA may shape patient outcomes.
    Journal
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    CEACAM5 (CEA Cell Adhesion Molecule 5) • PCAT6 (Prostate Cancer Associated Transcript 6)
    2years
    Development and verification of a combined immune- and cancer-associated fibroblast related prognostic signature for colon adenocarcinoma. (PubMed, Front Immunol)
    Knocking down S1PR5 can enhance the efficacy of PD-1 monoclonal antibody, promoting the cytotoxicity of T cells against HCT116 cells ((p<0.05). These findings indicate that the ICRG signature may be a valuable tool for predicting prognostic risk, evaluating the efficacy of immunotherapy, and tailoring personalized treatment options for patients with COAD.
    Journal • PD(L)-1 Biomarker • IO biomarker
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    MSI (Microsatellite instability) • IL20RB (Interleukin 20 Receptor Subunit Beta) • OSBPL1A (Oxysterol Binding Protein Like 1A) • FABP4 (Fatty Acid Binding Protein 4) • PCAT6 (Prostate Cancer Associated Transcript 6) • HSF4 (Heat Shock Transcription Factor 4) • KIF15 (Kinesin Family Member 15)
    2years
    Interplay between lncRNA/miRNA and Wnt/ß-catenin signaling in brain cancer tumorigenesis. (PubMed, EXCLI J)
    Therefore, recognition of the expression profile and regulatory role of ncRNAs on the Wnt signaling may offer a novel approach to the diagnosis, prognosis, and treatment of human cancers. This review summarizes previous data on the modulatory role of lncRNAs/miRNAs on the Wnt/β-catenin pathway implicated in tumor growth, EMT, metastasis, and chemoresistance in brain cancers.
    Review • Journal
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    HOTAIR (HOX Transcript Antisense RNA) • MIR27A (MicroRNA 27a) • DLGAP1-AS1 (DLGAP1 Antisense RNA 1) • GAS5 (Growth Arrest Specific 5) • MIR139 (MicroRNA 139) • MIR206 (MicroRNA 206) • MIR23b (MicroRNA 23b) • MIR506 (MicroRNA 506) • SNHG1 (Small Nucleolar RNA Host Gene 1) • MEG3 (Maternally Expressed 3) • MIR15A (MicroRNA 15a) • MIR217 (MicroRNA 217) • PCAT6 (Prostate Cancer Associated Transcript 6) • SNHG17 (Small Nucleolar RNA Host Gene 17) • SNHG7 (Small Nucleolar RNA Host Gene 7) • CRNDE (Colorectal Neoplasia Differentially Expressed)
    over2years
    AL360181.1 promotes proliferation and invasion in colon cancer and is one of ten m6A-related lncRNAs that predict overall survival. (PubMed, PeerJ)
    Moreover, AL360181.1 significantly promotes the proliferation, invasion and migration of colon cancer cells. Our results can provide direction for future studies on m6A-related lncRNA in colon cancer.
    Journal
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    PCAT6 (Prostate Cancer Associated Transcript 6)