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    BIOMARKER:

    PBRM1 overexpression

    i
    Other names: PBRM1, Polybromo 1, BAF180
    Entrez ID:
    55193
    Related biomarkers:
    Expression
    Mutation
    CNA
    Others
    over3years
    SDH- deficient renal cancer featured by the FBP1 loss, PKM2 overexpression and SWI/SNF chromatin remodeling complex aberrations: a rare case report. (PubMed, Oncologist)
    Therefore, the genetic analysis for germ line mutations in SDH genes in SDH-deficient RCC, especially in young individuals should be strongly recommended, although up to date is not obligatory. This knowledge will allow to improve the further patient monitoring including both disease recurrence and new cancer appearance.
    Clinical • Journal
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    PBRM1 (Polybromo 1) • SMARCA4 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily A, member 4) • SDHB (Succinate Dehydrogenase Complex Iron Sulfur Subunit B) • PKM (Pyruvate Kinase M1/2)
    |
    PBRM1 overexpression