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    BIOMARKER:

    PBRM1 deletion

    i
    Other names: PBRM1, Polybromo 1, BAF180
    Entrez ID:
    55193
    Related biomarkers:
    Expression
    Mutation
    Others
    over1year
    Clinicopathological Significance, Related Molecular Changes and Tumor Immune Response Analysis of the Abnormal SWI/SNF Complex Subunit PBRM1 in Gastric Adenocarcinoma. (PubMed, Pathol Oncol Res)
    Abnormality of the PBRM1 gene may be related to the occurrence of some GACs and can affect tumor immune activity, thereby affecting clinicopathology and prognosis. It may be a potentially effective predictive marker for immunotherapy and a novel therapeutic approach associated with synthetic lethality.
    Journal • PD(L)-1 Biomarker • IO biomarker
    |
    PD-L1 (Programmed death ligand 1) • PBRM1 (Polybromo 1)
    |
    PD-L1 expression • PBRM1 mutation • PBRM1 deletion
    almost2years
    Polybromo-1 missense mutations found in renal cancer patients affect bromodomain stability and biological function. (PubMed, FASEB J)
    Using recombinant PBRM1 BD4 mutants, we have assessed how the most common missense mutations found in patients affect the stability and acetyllysine binding of PBRM1 BD4, revealing new insight into bromodomain structure and function. In addition we have expressed a subset of these PBRM1 missense mutations in renal cancer cell lines and assessed how they affect PBRM1 binding to acetyllysine substrates, and subsequent renal cancer growth.
    Journal
    |
    PBRM1 (Polybromo 1)
    |
    PBRM1 mutation • VHL mutation • PBRM1 deletion • VHL deletion