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    BIOMARKER:

    PARP1 underexpression

    i
    Entrez ID:
    142
    Related biomarkers:
    Expression
    Mutation
    Others
    3years
    Identification of ATR inhibitors as therapeutic opportunities in Desmoplastic small round cell tumors (AACR 2022)
    DSRCT cells are sensitive to ATR and PARP inhibitors, through a mechanism that, at least in part, may involve enhanced replication stress and increased R-loop formation. Our data provide the preclinical rationale for assessing ATRi combined with PARPi in patients with DSRCT, as a cytotoxic therapy or as an immunomodulatory approach to enhance cell-autonomous immunogenicity.
    PARP Biomarker • PD(L)-1 Biomarker • IO biomarker
    |
    PD-L1 (Programmed death ligand 1) • WT1 (WT1 Transcription Factor) • CXCL10 (Chemokine (C-X-C motif) ligand 10) • RAD51 (RAD51 Homolog A) • EWSR1 (EWS RNA Binding Protein 1) • STING (stimulator of interferon response cGAMP interactor 1) • CCL5 (Chemokine (C-C motif) ligand 5)
    |
    PARP1 underexpression