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    BIOMARKER:

    PAPPA2 mutation

    i
    Other names: PAPPA2, Pappalysin 2, Pregnancy-Associated Plasma Protein E1, Placenta-Specific 3, Pappalysin-2, PAPP-A2, PAPP-E, PLAC3, Pregnancy-Associated Plasma Preproprotein-A2, Pregnancy-Associated Plasma Protein A2, PAPPE
    Entrez ID:
    60676
    Related biomarkers:
    Mutation
    Others
    over1year
    PAPPA2 mutation as a novel indicator stratifying beneficiaries of immune checkpoint inhibitors in skin cutaneous melanoma and non-small cell lung cancer. (PubMed, Cell Prolif)
    Our findings indicated that PAPPA2 mutation could serve as a novel indicator to stratify beneficiaries from ICIs therapy in NSCLC and SKCM, warranting further prospective studies.
    Journal • Checkpoint inhibition • Tumor Mutational Burden • IO biomarker
    |
    TMB (Tumor Mutational Burden) • LRP1B (LDL Receptor Related Protein 1B) • MUC16 (Mucin 16, Cell Surface Associated) • CD4 (CD4 Molecule) • PAPPA2 (Pappalysin 2)
    |
    MUC16 mutation • PAPPA2 mutation