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    BIOMARKER:

    PAK2 overexpression

    i
    Other names: PAK2, P21 (RAC1) Activated Kinase 2, S6/H4 Kinase, PAK65, P21 Protein (Cdc42/Rac)-Activated Kinase 2, Serine/Threonine-Protein Kinase PAK 2, P21 (CDKN1A)-Activated Kinase 2, P21-Activated Kinase 2, Gamma-PAK, PAKgamma, PAK-2, P58
    Entrez ID:
    5062
    9ms
    Circular RNA circ_0000119 promotes cervical cancer cell growth and migration via miR-433-3p/PAK2 axis. (PubMed, J Appl Genet)
    Moreover, circ_0000119 knockdown reduced tumor growth of CC in vivo. Circ_0000119 was upregulated in CC, and circ_0000119 knockdown suppressed CC malignant development through the miR-433-3p/PAK2 axis.
    Journal
    |
    PAK2 (P21 (RAC1) Activated Kinase 2) • MIR433 (MicroRNA 433)
    |
    PAK2 overexpression
    1year
    p21-activated kinase 2 binds to transcription factor SOX2 and up-regulates DEK to promote the progression of lung squamous cell carcinoma. (PubMed, Lab Invest)
    Moreover, SOX2 activated the expression of DEK, and silencing DEK attenuated the malignant behaviors of LSCC cells. In conclusion, PAK2 could bind to the transcription factor SOX2 and thus activate the expression of DEK, thereby driving the malignant phenotypes of LSCC cells both in vivo and in vitro.
    Journal
    |
    SOX2 • PAK2 (P21 (RAC1) Activated Kinase 2)
    |
    SOX2 overexpression • PAK2 overexpression • SOX2 expression
    over1year
    p21-activated kinase 2 binds to transcription factor SOX2 and up-regulates DEK to promote the progression of lung squamous cell carcinoma. (PubMed, Lab Invest)
    Moreover, SOX2 activated the expression of DEK, and silencing DEK attenuated the malignant behaviors of LSCC cells. In conclusion, PAK2 could bind to the transcription factor SOX2 and thus activate the expression of DEK, thereby driving the malignant phenotypes of LSCC cells both in vivo and in vitro.
    Journal
    |
    SOX2 • PAK2 (P21 (RAC1) Activated Kinase 2)
    |
    SOX2 overexpression • PAK2 overexpression • SOX2 expression